Báo cáo y học: "Common interleukin-6 promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis" pot

... study polymorphic effects on the synthesis of IL-6 have shown that its transcription and synthesis are affected by the allelic varia- tions within the gene, although the mechanism and level of the contribution ... in the light of the fact that both of these G alleles substantially increased the risk of symptomatic OA in our material. Individu- ally, the G allele o...

Ngày tải lên: 09/08/2014, 10:23

... antibody against the signal sequence of HSP60 was recognized only by the cytoplasmic HSP60 in the immunoblotting analysis. However, the antibody cross- reacted mainly with HSP60 in the cytoplasm ... the cytoplasm and mitochondria. Newly synthesized HSP60 in the cytoplasm will be imported into the mitochondria under appropriate conditions. In the present study, we observe...

Ngày tải lên: 08/03/2014, 09:20

... level of suspicion and the families of patients at risk are made aware of the possibility of this side e ffect. The symptoms of adrenal crisis include: hypotension and unexplained, acute hypoglycemia ... factors contributing to the potential for systemic side effects. A short-half life and high clearance rate reduce the expo- sure of the ICS to the systemic circulati...

Ngày tải lên: 08/08/2014, 21:20

... in the evening (thus synchronising its prednisone release to the circadian rhythm of cortisol), the duration of early morning stiffness in rheumatoid arthritis was less compared with that associated ... and the genomic actions transrepression and transactivation are not fully synonymous with inflammatory and immunosuppressive activity and with adverse effects, respectively....

Ngày tải lên: 09/08/2014, 01:22

... evidence strongly supports the above hypothesis that a histone- modifying enzyme such as EP300 involved in the first steps of transcription elongation may require a specific rotational setting of the first ... crucial RR (or YY) dinucleotides, elongation may not proceed with the required efficiency and may decrease the expression of the gene, thus poten- tially causing abn...

Ngày tải lên: 09/08/2014, 20:22

Ngày tải lên: 09/08/2014, 23:20

... supports the hypothesis that the hypersensitivity reaction to NVP may be HLA-associated [9,12,13], while HLA-alleles have also been identified as clinically relevant susceptibility markers for hypersensitiv- ity ... fre- quency of HLA-B*14 is nearly 0% in Japan. On the other hand, the frequency of HLA-Cw*08-positive patients in the NVP hypersensitive group was 42%, which was sig...

Ngày tải lên: 10/08/2014, 05:21

... not with AUD only. The haplotype TTGC formed by SNPs rs3805151, rs2412648, rs11240, rs2412646 was suggestively associated with increased risk for the comorbidity, with the odds ratio of 1.65. The ... contributions All the authors designed the study and the analysis. LK performed the genotyping. LS performed the statistical analysis. SS, MS, CL and TP as seniors guide...

Ngày tải lên: 10/08/2014, 09:20

... confirm the potential therapeutic value of these species. Table 5 The 6 categories of use comprising the 9 complaints, their respective number of animals mentioned by the migrant PE2 Category of use ... localized, the researcher selects interviewees based on their trial that they meet the criteria for the study of the phenom- enon of interest. After identifying pot...

Ngày tải lên: 10/08/2014, 09:21

... arch of the affected side, leading to an absence of the proximal pulmonary artery. Intrapul- monary vessels and distal portion of the affected pulmonary artery trunk can develop normally, and blood ... pulmonary vascular anatomy and collat- eral arterial supply [10]. Angiography remains the gold standard for the diagnosis of pulmonary artery agenesis. Currently with the...

Ngày tải lên: 10/08/2014, 23:22