Báo cáo y học: "Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection" docx

... 1 Research article Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection Tao Tang 1 , ... not induce the repair of osteochondral defect. Interestingly, remarkably strong staining for hyaluronan was demonstrated in areas that were...

Ngày tải lên: 09/08/2014, 10:22

... a therapeutic target in AKI. Modulation of these cytokines may reduce the degree of kidney injury itself, as well as the deleterious effects of kidney injury on other end organs, including the ... University of Cincinnati School of Medicine, Cincinnati, OH, USA 4 Section of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cin...

Ngày tải lên: 13/08/2014, 16:21

... alanine (6.5%). Thus, the alanine and glycine content of WSM was rather similar to that of EDTA-IM. In spite of the presence of mineral, it was possible to analyze the amino acid composition of the ... being quite glutamic acid- rich in WSM. Glycosaminoglycan analysis Glycosaminoglycans are highly negatively charged because of the presence of sulfate ester and/or...

Ngày tải lên: 21/02/2014, 01:21

... alternate interpretation of the lack of agonist-induced BRET observed in this study is that the translation of agonist binding to the ATDs of the family C GPCR homodimer into G-protein coupling of the ... 2002 Agonist-induced rearrangement of the 7TMs in the CaR homodimer? One of the goals of the present study was to investigate, whether the activating...

Ngày tải lên: 08/03/2014, 09:20

... scattered throughout the rheumatoid synovium, and most of the CCR1-positive cells are macrophages, which play a key role in synovial inflammation. The rationale for the clinical study was supported by interesting ... on the available in vivo data, which may provide more insight into the chances that disrupting one single factor of the complicated chemokine network could...

Ngày tải lên: 09/08/2014, 01:23

... processes underlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAH increases the importance ... vasculopathy of SScl may also be modifiable. In the characteristic microangiopathy of SScl, luminal narrowing results from a combination of intimal prolifera...

Ngày tải lên: 09/08/2014, 06:23

... supporting the importance of intercellular contacts in the pathogenic mechanisms underlying RA. Indeed, the importance of these cell-cell interactions in the synthesis and release of pro-inflam- matory ... currently the most important cytokine in the pathogenesis of RA, the mechanisms involved in the perpetuation of TNF production in the rheumatoid syn- o...

Ngày tải lên: 09/08/2014, 08:22

... important in the proliferation of RA FLSs in the pathogenesis of RA. Introduction Synovial tissue from healthy individuals consists of a single layer of synovial cells without infiltration of inflammatory ... purposes) Figure 5 Inhibitory effects of neutralizing antibodies to cytokines on the SF-mediated proliferation capacity of RA FLSsInhibitory effects of neutrali...

Ngày tải lên: 09/08/2014, 08:23

... neutrophil-specific protein Pyrin [2]. Most evidence currently suggests that pyrin negatively regulates the production of IL-1β – a major proinflammatory cytokine of the innate immune response ... intracellular domain of TNFR1. A definitive list of all the TRAPS mutations can be found on the INFEVERS website [43]. Many of the mutations involve cysteine residues involved i...

Ngày tải lên: 09/08/2014, 10:20

... type II synthesis, whereas proteoglycan synthesis was strongly attenuated. In contrast, at the time of maximal aggre- canase activity, the proteoglycan loss was fully reversible. These findings ... points. Proteoglycans in the cartilage were visualized using Alcian blue staining, the same dye used in the S-GAG assay. The control articular car- tilage explants (shown in...

Ngày tải lên: 09/08/2014, 10:23