Báo cáo y học: "Complement and arthritis: another step in understanding" ppt

... gene deletion and lead to an increase in Editorial Complement and arthritis: another step in understanding Michael M Frank and C Garren Hester Department of Pediatrics, Duke University Medical Center, ... MRL/lpr mice. Wenderfer and colleagues [1] have carried this analysis further by examining the effect of C4 binding protein (C4bp) deficiency in the MRL/lpr model. Their...

Ngày tải lên: 09/08/2014, 10:22

... many kinds of different cytokines and growth factors in the RA joint microenvironments. To identify factors having an effect on the growth of RA FLSs, we investigated the inflam- matory cytokines ... inflammatory cells. In rheumatoid synovial tissue, lymphocytes and macrophages are recruited and activated, and these activated macrophages release high concentrations of inflammatory...

Ngày tải lên: 09/08/2014, 08:23

... Considering the arthritis-inducing capacity of antibodies characteristic for RA [5], the new opportunity to study surface expression of inhibitory and activating FcγRs will lead to enhanced understanding ... of activating FcγR-expressing cells and T cells in RA synovial tissue [1]. By enhancing the capacity of effector T cells to activate B cells as well as fibroblasts and osteoclasts...

Ngày tải lên: 09/08/2014, 10:20

... monoctyes/macrophages in isolated PMN populations, suggesting that contaminating cells are unlikely to have a significant role in the chemokine profile determined by microarray analysis. In addition, ... between PMN and mononuclear cells was approximately 1:10. Flow cytometry The purity of PMN was routinely analyzed by flow cytometry with FACSCalibur (BD Biosciences, Heidelberg, Germa...

Ngày tải lên: 09/08/2014, 10:21

... Rheumatology; AS: ankylosing spondylitis; ASAS: Assessment of SpondyloArthritis International Society; BASDAI: Bath Ankylos- ing Spondylitis Disease Activity Index; BASFI: Bath Ankylosing Spondylitis ... history of therapy with IFX or ETN or both: Review of Safety and Effectiveness witH Adali- mumab in Patients with Active Ankylosing SpOnDYlitis (RHAPSODY) and SafeTy and Efficacy of A...

Ngày tải lên: 12/08/2014, 14:22

... (dehydro- genation, hydroxylation, and N-dealkylation), mainly by cytochrome P450 2D6 (CYP2D6) and cytochrome P450 3A4 (CYP3A4) [60]. The parenteral drug is excreted only in traces. There is only ... Pharmacokinetics and tolerability of intra- muscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia. Clin Pharmacokinet 2008, 47:475-485...

Ngày tải lên: 08/08/2014, 23:21

... schizophrenia. Patients included in the study ranged in age between 18 and 45 years and had a history of two or more relapses during the course of their illness despite getting treatment. The patients and their ... acting on the central nervous system and those with clinical evidence of epilepsy or intellectual disability were excluded. One adult relative living with the patient...

Ngày tải lên: 08/08/2014, 23:21

... transcription in human monocytes. Blood 1997, 89:4461. 10. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM: IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation ... in rheumatoid arthritis by interleukin-10 and interleukin-4. Arthri- tis Rheum 1996, 39:829. 19. Walmsley M, Katsikis PD, Abney E, Parry S, Williams RO, Maini RN, Feldmann M: Inte...

Ngày tải lên: 09/08/2014, 01:21

... Klein T, Backman JT, Saal JG, Nüsing RM, Fritz P: Expres- sion of cyclooxygenase 1 and cyclooxygenase 2 in human syn- ovial tissue: Differential elevation of cyclooxygenase 2 in inflammatory joint ... distribution of cyclooxygenase (COX)-1 and COX-2 and PGE 2 receptor types EP1, EP2, EP3 and EP4 in the growth plate in situ and in vitro. PGE 2 synthesis was determined by...

Ngày tải lên: 09/08/2014, 08:22

... of disease pathology has yet to be fully examined. A role for the proinflammatory cytokines TNFα and IL-1β in innervation of the IVD [22] and in degeneration of the IVD has been demonstrated by a number ... article Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc Devina Purmessur, Anthony J Freemont and Judith A Hoyland T...

Ngày tải lên: 09/08/2014, 11:20