Báo cáo y học: "Inhibition of hyaluronan export reduces collagen degradation in interleukin-1 treated cartilage" pot

... three inhibitors. Figure 1 Inhibition of hyaluronan export in bovine chondrocytesInhibition of hyaluronan export in bovine chondrocytes. (a) Cartilage explants were incubated in the absence and presence of IL-1α ... drugs inhibited hyaluronan export, but they did not inhibit hyaluronan synthase activity. Simultaneously, they inhibited proteoglycan loss and collagen...

Ngày tải lên: 09/08/2014, 10:22

... level of the has operon containing the hyaluronan synthase gene or the protein level of hyaluronan synthase. Solubilization of the enzyme from membranes of MU -treated cells and addition of the ... n-dodecyl-b- D -maltoside; GlcNAc, N-acetylglucosamine; GlcUA, glucuronic acid; HA, hyaluronan (hyaluronic acid); HABP, hyaluronan binding protein; HAS (Has), hyaluronan syntha...

Ngày tải lên: 08/03/2014, 09:20

... nonproductively infected [14]. The number of astrocytes in the brain ranges up to 2 × 10 12 , and while only 1% of these cells may be latently infected, the total number of infected astrocytes contribut- ing ... viability of mock treated cells (Fig. 2B). Analysis of growth kinetics and viability in T cells treated with S. fusiformeFigure 1 Analysis of growth kinetics and v...

Ngày tải lên: 10/08/2014, 05:20

... attenuated vaccines against viruses with a a2,6 binding preference in young turkeys and in ovo inoculations. Lectin binding patterns are not indicative of virus binding patterns Glycan micro arrays have ... hemagglutinin bind to alpha2,8-linked sialic acid. Virology 2004, 325:11. 17. Gambaryan A, Tuzikov A, Pazynina G, Bovin N, Balish A, Kilmov A: Evolution of the receptor binding phe...

Ngày tải lên: 11/08/2014, 21:21

... monooxygenated protopanaxadiol are metabolites of all three ginsenosides. Conclusion: Oxygenation and deglycosylation are two major metabolic pathways of the ginsenosides in rat gastrointestinal ... damage, maintains normal cholesterol and blood pressure [10] and inhibits the induction phase of long-term potentia- tion by high frequency stimulation in the dentate gyrus of the bra...

Ngày tải lên: 13/08/2014, 15:21

... inhibition of ERK1/2 phosphorylation may be lying upstream of ERK1/2. Using a serine/threonine kinase SPA assay kit, the capability of NAMI-A to affect the ERK1/2 phosphoryla- tion activity was also assessed. ... Ventura,C.,Pintus,G.,Fiori,M.G.,Bennardini,F.,Pinna,G.& Gaspa, L. (1997) Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster....

Ngày tải lên: 21/02/2014, 01:21

... splicing apparatus. The inhibitory effect of erythromycin and Cl-tetracycline were not allevi- ated by Mg 2+ (Fig. 3). Kinetic analyses using increasing concentrations of erythromycin, Cl-tetracycline ... was reduced by 60% in the presence of 500 l M Cl-tetracycline and by 95% in t he presence of 500 l M erythromycin and streptomycin (Fig. 2B,C). Tetracycline at 500 l M inhibited...

Ngày tải lên: 21/02/2014, 15:20

... activity of a number of key enzymes such as cyclooxygenase [9], protein kinase C [10], protein tyrosine kinases [11] and a Ca 2þ -dependent endonuclease [12]. Many of these processes/enzymes are ... processes including: activation of apoptosis in Jurkat T-cells [5], inhibition of platelet aggregation [6,7] and inhibition of in ammatory cytokine production in macrophages [8]....

Ngày tải lên: 08/03/2014, 23:20

... transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. ... organisms. In all systems investigated so far, mannosamine was able to inhibit GPtdIns biosynthesis. In T. brucei, mannosamine inhibits the incorporation of ethanolami...

Ngày tải lên: 31/03/2014, 23:20

... FEBS 2002 Inhibition of SERCA Ca 2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca 2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the ... Ca 2+ bindingbyboth reducing the rate constant for binding as well as increasing therateconstantforCa 2+ dissociation, could be explained by 2-APB binding to either one or both of these sit...

Ngày tải lên: 31/03/2014, 23:20