Báo cáo y học: "Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro" ppt
Báo cáo y học: "Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro" ppt
... and Figure 2 Release of glycosaminoglycans into the culture medium following an impact load on articular cartilage explantsRelease of glycosaminoglycans into the culture medium following an impact ... number not for citation purposes) Vol 9 No 6 Research article Cyclooxygenase inhibition lowers prostaglandin E 2 release from articular cartilage and red...
Ngày tải lên: 09/08/2014, 10:22
Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
... mechanism of nicking both DNA strands a short dis- tance apart. Nicking and binding to the DNA end would not only create broken strands, but adducts that would likely interrupt replication and ... evi- dence for an interaction between NS1 and PARP. Since PARP is active at the site of single strand DNA breaks, and single-strand nicking is a known activity of NS1 protein, it...
Ngày tải lên: 25/10/2012, 11:18
Tài liệu Báo cáo Y học: Interaction of decorin with CNBr peptides from collagens I and II Evidence for multiple binding sites and essential lysyl residues in collagen pot
... location and the relative o rientation of the binding sites in decorin and collagen are not yet known. Our findings on multiple binding sites in collagen and on the relevance of Lys/Hyl residues ... or tendon, using type I collagen as the ligand (30 and 16 n M ) [47,48]. Other experiments (not shown) indicated that ionic interactions play an impor tant role in the bin ding b...
Ngày tải lên: 21/02/2014, 15:20
Báo cáo y học: "RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro" pps
... hours in the absence or presence of RANKL. Changes in cell morphology and induction of apoptosis were examined by scanning electron microscopy, whilst resorptive activity was determined by measuring ... cavities. Changes in the level of anti-apoptotic proteins, including Mcl-1, Bcl-2, and Bcl-x >L , were determined in rabbit osteoclasts and in cytokine-starved mouse osteo...
Ngày tải lên: 09/08/2014, 14:20
Báo cáo y học: "Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels" ppt
... design, and per- formed and analyzed experiments, CG and LS performed experiments, SK and RA participated in study design, MR conceived and coordinated the study, ana- lyzed data and drafted the manuscript. ... Scien- tific) and quality was controlled on agarose gels or using the Agilent Bioanalyzer (Böblingen, Germany). Whole genome expression analysis Labeling, hybridization...
Ngày tải lên: 09/08/2014, 20:22
Báo cáo Y học: Growth inhibition of mammalian cells by eosinophil cationic protein pptx
... tes with an entirely human immunotoxin analogue: human pancreatic RNase1-human IL-2 fusion. Cytokine 12 , 786±790. 57. Reiter, Y. & Pastan, I. (1998) Recombinant Fv immunotoxins and Fvfragmentsasnovelagentsforcancertherapyanddiagnosis. Trends ... Igarashi, K., Shing, Y. ,Folkman,J.,Ueda,M.&Yamada,H.(1996)Humanbeta- cellulin, a member o f the EGF fa mily dominantly expressed in...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo y học: "Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride" ppsx
... Laboratories, Wilmington, MA, USA). During the study, the animals were maintained in a facility fully accredited by the Stand- ards Council of Canada (SCC) and the care and use of the animals was conducted in ... in the Swiss albino mouse model. Materials and methods The study protocol and any amendment(s) or procedures involving the care and use of animals were reviewed and...
Ngày tải lên: 08/08/2014, 23:20
Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
... predominantly in the syn- ovial lining layer and in endothelial cells in the synovium [10]. The lining layer consists mainly of fibroblasts and macrophages, both important players in the process of inflammation ... response to a variety of stimuli both in pri- mary cells and in cell lines [9]. In the RA synovium, p38 MAPK is predominantly activated in endothelial cells...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
... stimulation in human umbilical vein endothelial cells (HUVECs) as determined by flow cytometry. Minus and plus signs and denotes resting, non-infected, and TNF-α activated, non-infected HUVECs, ... to thank HE Moorlag (Endothelial Cell Facility UMCG, Gronin- gen, The Netherlands) for isolating and culturing HUVECs and Drs Sebo Withoff and Robbert Jan Kok (RUG, Groningen, The N...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect" ppsx
... potent lipooxygenase inhibitor. The results observed in a preliminary trial suggest a highly intriguing clinically relevant symptomatic effect contrasting with a poor bioavailability of this compound. ... against cytokines such as tumor necrosis factor (TNF), interleukin-6, and so on) or against some specific enzyme (for example, cyclooxygenases). The compound evaluated in the trial rep...
Ngày tải lên: 09/08/2014, 11:20