Báo cáo y học: "Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro" ppt
Báo cáo y học: "Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro" ppt
... and Figure 2 Release of glycosaminoglycans into the culture medium following an impact load on articular cartilage explantsRelease of glycosaminoglycans into the culture medium following an impact ... number not for citation purposes)Vol 9 No 6Research articleCyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation ... prostanoid may have a role in the increased apopto-sis observed following trauma. In an attempt to understand the physical and biochemicalchanges occurring in articular cartilage following trauma,...
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Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
... mechanism of nicking both DNA strands a short dis-tance apart. Nicking and binding to the DNA end would not only create broken strands, but adducts that would likely interrupt replication and ... evi-dence for an interaction between NS1 and PARP. Since PARP is active at the site of single strand DNA breaks, and single-strand nicking is a known activity of NS1 protein, it is likely that NS1 ... expression in mice and spontane-ous expression in human SLE of polyomavirus T-antigen. A molecular basis for induction of antibodies to DNA and euka-ryotic transcription factors. J Clin Invest...
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Tài liệu Báo cáo Y học: Interaction of decorin with CNBr peptides from collagens I and II Evidence for multiple binding sites and essential lysyl residues in collagen pot
... location and the relative o rientation of the binding sites in decorin and collagen are not yet known. Our findings on multiplebinding sites in collagen and on the relevance of Lys/Hylresidues ... ortendon, using type I collagen as the ligand (30 and 16 nM)[47,48].Other experiments (not shown) indicated that ionicinteractions play an impor tant role in the bin ding betweendecorin and collagen. ... is in contrast with the findings that the binding sitefor decorin is located in a seq uence within the peptide a1(I)CB6 devoid of any Lys/Hyl residue and containing, as ionicamino acids, only...
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Báo cáo y học: "RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro" pps
... hours in the absence or presence of RANKL. Changes in cellmorphology and induction of apoptosis were examined byscanning electron microscopy, whilst resorptive activity wasdetermined by measuring ... cavities.Changes in the level of anti-apoptotic proteins, including Mcl-1,Bcl-2, and Bcl-x>L, were determined in rabbit osteoclasts and in cytokine-starved mouse osteoclasts by Western blotting.Results ... for analysis by scanning EM asdescribed above.Statistical analysisThe effects of BPs and RANKL on osteoclast number, osteo-clast apoptosis, bone resorption, and caspase-9 activity wereanalysed...
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Báo cáo y học: "Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels" ppt
... design, and per-formed and analyzed experiments, CG and LS performed experiments, SK and RA participated in study design, MR conceived and coordinated the study, ana-lyzed data and drafted the manuscript. ... Scien-tific) and quality was controlled on agarose gels or usingthe Agilent Bioanalyzer (Böblingen, Germany).Whole genome expression analysisLabeling, hybridization and scanning of high quality RNAwas ... dimethyl histone H3 lysine 4 (H3K4me2) and trimethyl histone H3 lysine 4 (H3K4me3) as well as against acetylated histones H3 and H4 (AcH3 and AcH4). The IgG background level is indicated by the...
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Báo cáo Y học: Growth inhibition of mammalian cells by eosinophil cationic protein pptx
... teswith an entirely human immunotoxin analogue: human pancreaticRNase1-human IL-2 fusion. Cytokine 12 , 786±790.57. Reiter, Y. & Pastan, I. (1998) Recombinant Fv immunotoxins and Fvfragmentsasnovelagentsforcancertherapyanddiagnosis.Trends ... Igarashi, K., Shing, Y. ,Folkman,J.,Ueda,M.&Yamada,H.(1996)Humanbeta-cellulin, a member o f the EGF fa mily dominantly expressed in pancreas and small intestine, is fully active in a monomeric ... Tat protein may beimportant for the uptake of the protein into cells [50]. Thismechanism may not apply to ECP as ECP is an arginine-rich protein but does not have the cluster of arginineresidues...
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Báo cáo y học: "Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride" ppsx
... Laboratories,Wilmington, MA, USA). During the study, the animalswere maintained in a facility fully accredited by the Stand-ards Council of Canada (SCC) and the care and use of theanimals was conducted in ... in the Swiss albino mousemodel.Materials and methodsThe study protocol and any amendment(s) or proceduresinvolving the care and use of animals were reviewed and approved by an appropriate ... graded using Charles River Laboratories, Inc.'sgrading system of mild: head and tail slightly extended and little jerking; moderate: head and tail fully extended and some jerking; or severe:...
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Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
... predominantly in the syn-ovial lining layer and in endothelial cells in the synovium[10]. The lining layer consists mainly of fibroblasts and macrophages, both important players in the process ofinflammation ... response to a variety of stimuli both in pri-mary cells and in cell lines [9]. In the RA synovium, p38MAPK is predominantly activated in endothelial cells and in the lining layer [10]. Inhibition of ... macro-phage-colony-stimulating factor and 1% FCS after 5 days (right panel), measured by flow cytometry and expressed in mean fluorescence intensity (MFI). The isotype control is an IgG2a antibody (dashed line);...
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Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
... stimulation in human umbilical vein endothelial cells (HUVECs) as determined by flow cytometry. Minus and plus signs and denotes resting, non-infected, and TNF-α activated, non-infected HUVECs, ... to thank HE Moorlag (Endothelial Cell Facility UMCG, Gronin-gen, The Netherlands) for isolating and culturing HUVECs and Drs Sebo Withoff and Robbert Jan Kok (RUG, Groningen, The Netherlands) ... RGDpep and RADpep, respectively, were pre-pared by Ansynth (Roosendaal, The Netherlands). This RGD-pep was previously conjugated to a humanized antibody thatdoes not recognize any epitope relevant...
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Báo cáo y học: "Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect" ppsx
... potent lipooxygenase inhibitor. The resultsobserved in a preliminary trial suggest a highly intriguing clinicallyrelevant symptomatic effect contrasting with a poor bioavailabilityof this compound. ... against cytokines such as tumor necrosis factor(TNF), interleukin-6, and so on) or against some specificenzyme (for example, cyclooxygenases). The compoundevaluated in the trial reported by ... levels.EditorialLipooxygenase inhibition in osteoarthritis: a potentialsymptomatic and disease modifying effect?Maxime DougadosParis-Descartes University, Medicine Faculty; UPRES-EA 4058; AP-HP, Cochin Hospital,...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Tổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ