Báo cáo y học: "Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts" pps

... activity is detectable in celecoxib- treated rheumatoid arthritis fibroblast-like synoviocytes One mechanism that is consistently implicated in apoptosis is the activation of a cascade of cytosolic ... Access Available online http:/ /arthritis- research.com/content/9/6/R128 Page 1 of 11 (page number not for citation purposes) Vol 9 No 6 Research article Apoptosis is not...

Ngày tải lên: 09/08/2014, 10:22

... proinflam- matory cytokine produced by the rheumatoid arthritis syn- ovium. Arthritis Rheum 1999, 42:963-970. 17. Cho ML, Yoon CH, Hwang SY, Park MK, Min SY, Lee SH, Park SH, Kim HY: Effector function of type ... IL-17 on IL-1 -induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regu- lation by Th2 cytokines. J Immunol 1998,...

Ngày tải lên: 09/08/2014, 01:23

... epiphenomenon [10]. One of the unresolved issues is the inability to explain the nonrandom, selected organ injury that defines the WG vasculitis and the concurrent, seemingly random, nature of injury ... expression can be induced by cytokines in human endothelial cells [13,14]. The lung is the organ most frequently involved in WG, and in some cases it is the only org...

Ngày tải lên: 09/08/2014, 03:24

... revolutionized the therapy of rheumatoid arthritis (RA). It inhibits both inflammation and destruction of joints, in a majority of patients suffering from RA [3-5]. The hypoth- esis is supported by ... inhibition of JNK2 is not effective to block destruc- tive arthritis and raises the question whether JNK1 is a more promising target or effective inhibition of arthritis...

Ngày tải lên: 09/08/2014, 06:22

... histocompatibility complex, relapsing polychondritis Introduction Autoimmune diseases that affect cartilage tissue are wide- spread in the population. The most common one is rheuma- toid arthritis (RA), ... controlled by the MHC region, as mice congenic at the H2 region differed in susceptibility to disease. As in mouse models for arthritis, mice carrying the H2 q haplotype...

Ngày tải lên: 09/08/2014, 01:24

... with long-standing disease were phenotyped by flow cytometry. As depicted in Figure 2a for one representative patient, the major- ity of the synovial B cells express CD27. In this patient cohort the ... Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling path...

Ngày tải lên: 09/08/2014, 14:21

... depletion in early RA, which is currently under evaluation in controlled trials. Conclusions The elevation of markers of B-cell activation in very early RA demonstrates that B-cell activation is ... A, Baron D, Pennec Y, Botton E, Mary JY, Le Goff P, Youinou P: Ability of the American College of Rheumatology 1987 criteria to predict rheumatoid arthritis in patients with early ar...

Ngày tải lên: 09/08/2014, 14:22

... rotation [45]. Interestingly, gut malrotation is a common feature of heterotaxy and is consistent with a laterality disorder. In Xenopus, Shroom3 is expressed in the myocardium and is necessary ... SNP genotyping analysis (Table 2 and Figure 1), consistent with the known consanguinity in the pedigree. These regions have an overwhelming probability to carry disease mutations i...

Ngày tải lên: 09/08/2014, 23:20

... satisfactory if the nerve was intact and only compressed by fibrosis or the nerve was in-contunuity with neuroma or fibrosis. Conclusion: Appropriate surgical techniques help the recovery from the ... surgery because of the mechanism of injuries. Gunshot wounds to the brachial plexus usually result in lesions- in- continuity, but, the patients with a large majority of these...

Ngày tải lên: 10/08/2014, 10:20

... salmonellosi s or of symptoms referable to the aneurysm. Discussion To the best of our knowledge, this case is the first docu- mented Salmonella -induced mycoti c aneurysm affecting an artery supp ... aneurysm produced by another cause. Given the Figure 2 Grossly-enlarged aneurysm of his inferior gluteal artery (arrow) compressing his sciatic nerve (arrowhead) found at our surger...

Ngày tải lên: 11/08/2014, 03:21