Báo cáo y học: "Activation of proteinase-activated receptor

Báo cáo y học: "Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study" pot

... of data, statistical analysis, and manuscript preparation. NA participated in acquisition of data, analysis and interpretation of data, statistical analysis, and manuscript preparation. JMP and ... citation purposes) Vol 9 No 6 Research article Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proin...

Ngày tải lên : 09/08/2014, 10:22

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Báo cáo y học: "Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review" pot

... hospitalizations each year. 1 Previously characterized as a disease of air- way smooth muscle, asthma is currently defined by the National Heart, Lung, and Blood Institute as a chronic inflammatory ... and adults, result- ing in increased physical activity and quality of life. Figure 2 Comparison of montelukast (ϫ) with sal- meterol (•) in change from baseline in maximu...

Ngày tải lên : 08/08/2014, 20:23

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Báo cáo y học: "Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B" ppsx

... JR and VK undertook some of the genotyping assays on DNA prepared in the laboratory of EAJ and RWO, who participated in the original design of the study. FP and MA gave invaluable advice during ... IIIB-NA1PR. The NA2 assay similarly included the IIIB-NA2F and IIIB-NA2R ARMS primers and internal control primers IIIB-NA2PR and IIIB-NA2PR from the gene MCSD1. Statistical...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf

... 8 325 -4 and its mutants lacking aureolysin, serine protease, and cysteine protease, demonstrated in a murine SA model that inactivation of the Figure 4 Potentiation of matrix metalloproteinase ... an inflammatory cytokine-mediated pathway in the observed induction of MMPs by S. aureus. S. aureus culture supernatants and cell lysates have a wide variety of proteins, and...

Ngày tải lên : 09/08/2014, 08:23

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Báo cáo Y học: Activation of transcription through the ligand-binding pocket of the orphan nuclear receptor ultraspiracle docx

... CGGTATTTCACACCG CAcATGGTGCACT CTCAGTACAATC. The primer to mutate Q288 to alanine in the ligand-binding pocket was: GTGCCAAGTGGTCA ACAAA gcGCTCTTCCAGATGGTCGAATAC. A primer that targeted two amino ... transcriptionally activate or antagonize an orphan receptor would aid the discovery of regulatory pathways in which the receptor participates. Finally, transcriptional agonists an...

Ngày tải lên : 23/03/2014, 21:20

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Báo cáo Y học: Activation of transcription of the human presenilin 1 gene by 12-O-tetradecanoylphorbol 13-acetate pdf

... protein involved in the regulation of gamma secretase cleavage generating amyloid beta protein [3] and appears to play a crucial role in the normal metabolism of beta amyloid precursor protein as well ... the constructs are indicated below the graph. m1 is a mutation from CCGGAAATGACGA to CC ttAAATGACGA eliminating the )10 Ets site. In m6 the mutation to CCGGAAAT cgaGA elimina...

Ngày tải lên : 08/03/2014, 09:20

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Báo cáo Y học: Activation of a covalent outer membrane phospholipase A dimer pptx

... observation that OMPLA variants having an impaired dimeric interface also lacked high a nity calcium binding. A covalent linkage was not able to restore high a nity calcium binding in these variants, ... noteworthy that all mutations at the dimer interface are located at more than 15 A ˚ from the catalytic calcium ion (Fig. 1B). In the standard assay, wild- type OMPLA has a calciu...

Ngày tải lên : 24/03/2014, 03:21

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báo cáo hóa học: " Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation" pptx

... suppressors of cytokine signaling (SOCS-1 and 3). The SOCS proteins act as negative regulators of the JAK/STAT1 pathway either by binding and inhibiting JAK tyrosine kinases or by inhibiting binding of ... phospho-specific Tyr1 022 /1 023 JAK1 or Tyr1007/1008 JAK2 antibody (Cell Signaling Technology, Beverly, MA) and then stripped and finally analyzed by total JAK1 or JAK2 anti...

Ngày tải lên : 19/06/2014, 22:20

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Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx

... Freeman GJ: The B7-CD28 superfamily. Nat Rev Immunol 20 02, 2: 116- 126 . 20 . Matsuyama T, Yamada A, Kay J, Yamada KM, Akiyama SK, Schlossman SF, Morimoto C: Activation of CD4 cells by fibronectin and ... 12- myristate 13-acetate (PMA) and ionomycin for 24 h or frozen directly in TriReagent for RNA isolation and real-time polymerase chain reaction, as described in Materials...

Ngày tải lên : 09/08/2014, 01:23

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Báo cáo y học: "levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control" docx

... joint and recorded in proximal interphalangeal joints, metacarpophalangeal joints, carpal joints, wrist joints and met- atarsophalangeal joints. Thirty-nine patients out of 62 had ero- sive disease. ... that soluble RAGE may block the ligand–RAGE interaction on the cell surface by directly binding leukocyte 2- integrin Mac-1 and thereby decreasing influx of inflammatory cells i...

Ngày tải lên : 09/08/2014, 06:23

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