Báo cáo y học: "Recruitment of dendritic cells and macrophages during T cell-mediated synovial inflammation" doc
Báo cáo y học: "Recruitment of dendritic cells and macrophages during T cell-mediated synovial inflammation" doc
... Theseobservations provide qualitative support to the quantitativestudies on inflammatory cells obtained from SRT by enzymaticdigestion (Figure 3c). Importantly, they show that Mϕ are anumerically small ... DA strain rats provides an excellentmodel in which to study APCs during the effector phase of T cell-mediated autoimmunity. Firstly, activated CD4+ T cells from central lymph of arthritic ... examination of cell subsets during adoptively trans-ferred disease and estimation of numbers of cells in the vari-ous subsets by calibrated flow cytometry. Estimation of numbers of acute inflammatory...
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Báo cáo Y học: Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells docx
... substrate-binding and substrate-releasing conform-ational states. The consecutive steps of the catalytic cycleappear to be discriminated by the changing affinity of Pgpto the UIC2 mAb [18,30]. Reactivity of ... nonsubstrate agents interfering with theATPase cycle. To study this question, we compared theeffects of Pianalogues (Vi,BeFx,AlF4), trapping nucleotidesat the catalytic site of Pgp, and of ... Viintermediate occurs randomly at one of the two nucleotide-binding sites of Pgp, but not simulta-neously [14–16]. It has been demonstrated in photoaffinitylabeling experiments that the affinity...
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Báo cáo y học: " Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen" pptx
... degradation and havebegun to alleviate inflammation.Many recent studies have reported that IL-10, a major anti-inflammatory cytokine secreted by Th2 lymphocytes,contributes to the process of peripheral ... oedema and erythema from the ankle tothe tarsal bone; 3 = moderate oedema and erythema fromthe ankle to the tarsal bone; and 4 = oedema and erythema from the ankle to the entire leg. The sum of values ... suggested that thepossible mechanism may involve secretion of anti-inflammatory cytokines including IL-4, IL-10 and transforming growth factor (TGF)-β by mucosal T lymphocytes that have differentiated...
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Báo cáo y học: "Management of HCV Infection and Liver Transplantation"
... candidates for interferon therapy as it was believed that in the setting of hepatic encephalopathy, ascites and protein malnutrition they would not tolerate therapy and also that their liver disease ... patient's often poor performance status, their increased susceptibility to infection and rejection, and the presence of anemia and renal dysfunction that lessen the tolerability of interferon ... discontinue therapy. Although thrombocytopenia may persist after portal hypertension resolves post-transplant, it is rarely a limiting factor to pegylated interferon use. We treat patients for...
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... suggests that MU acts to inhibit the HA synthesispathway but not to stimulate the HA degradation pathway.In the present study, we showed that MU did not directlyinhibit HAS activity even at a ... length and unsaturation pattern, and that the MU treatment of cells decreases the availability of these favorable CL species. Additionally, the interaction of HAS with CL species that have quite ... although thestimulated activity did not reach that of MU-untreatedsamples. This deficiency of reconstituting HA synthesisactivity at 2 mMMU can be explained by the decreased level of HAS protein...
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Báo cáo Y học: Fusion of farnesyldiphosphate synthase and epi-aristolochene synthase, a sesquiterpene cyclase involved in capsidiol biosynthesis in Nicotiana tabacum docx
... 5¢-CTACTCGAGCTACTTTTGCCTCTTGTA-3 FPPS C-terminalP3 5¢-TAGAGCCATGGCCTCAGCAGCAGTT¢-3¢ eAS N-terminalP4 5¢-CTACTCGAGTCAAATTTTGATGGAGTC-3¢ eAS C-terminalP5 5¢-TAGGATCCCTTTTGCCTCTTGTAAAT-3¢ FPPS C-terminalP6 ... laboratory.It is interesting to note that the highest activity of therelatively large recombinant protein (119.9 kDa) isobserved at 30 °C. We assume this to be due to the factthat the fused enzyme ... carried out for one of the constructs, i.e. pET32 eAS/FPPS. The amount of eASactivity was determined as a function of incubation timeafter addition of IPTG, concentration of IPTG and induction temperature....
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Báo cáo y học: "Correlation of the Radiographic and Morphological Features of the Dental Follicle of Third Molars with Incomplete Root Formation" ppsx
... demonstrated its importance in the process of eruption. Consolaro [6] states that the potential transformation of unerupted teeth into cystic or neoplastic ones is related to the constituent structures ... Int. J. Med. Sci. 2008, 5 37tooth and that a number of studies show the possibility of cystic degeneration and/ or neoplastic transformation of the follicles, the present study evaluated ... sheets or layers of cells [10]. In the evaluation of the connective tissue an analysis was made of the type to verify whether it was dense or loose and whether inflammation was present, the...
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Báo cáo y học: "Sales of antidepressants, suicides and hospital admissions for depression in Veneto Region, Italy, from 2000 to 2005: an ecological study" doc
... disease that required the prescription of the antidepressant. However, since anxiety and depression are closely intermingled, the former often being an indicator of the severity of the latter and ... with some notable differences between the North and the South [16]. Consequently, trends in the whole of Italy may not be representative of a specific region. Veneto is a north-east Italian ... theory received a standard dose (that is, the DDD) of a particular medication or category of medication daily. Data on numbers of suicide deaths according to the Ninth Revision of the Italian...
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Báo cáo y học: "Adult mesenchymal stem cells and cell-based tissue engineering" doc
... protein within the extracellular matrix,suggesting the potential utility of this construct for tissue-engineered therapy of articular cartilage defects [117].Our recent attempts to fabricate ... but possesses very limited potentialfor healing. Current treatment methods for restoration of function due to articular cartilage damage, other than totaljoint arthroplasty, include autografting, ... elevated expression of Wnt-5a byactivated synovium and established disease markers [90].It is postulated that the presence of activated synoviocytesin the rheumatoid arthritic joint may be...
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Báo cáo y học: "ragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis" ppt
... recognized byautoantibodies.In the present study, Jurkat cells were relatively sensitiveto the treatment with STS such that the kinetics of degra-dation of different golgins relative to that of PARP ... without generation of intermediate pro-tease-resistant fragments, it cannot be ruled out that theintact proteins were released from apoptotic cells or thattheir apoptotic fragments were not recognized ... necrosis and this has raised the possibility that celldeath may play a role in the generation of potentiallyimmunostimulatory forms of autoantigens. In the present study,we examined changes in the...
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