Báo cáo y học: "Increased lymphangiogenesis in joints of mice with inflammatory arthritis" pptx

... importance of lymphangiogenesis in the pathogen- esis of RA remains to be determined. Conclusion Our findings demonstrate that lymphangiogenesis is signifi- cantly increased in joints of mice with inflammatory ... synovitis correlated with draining lymph node size. In summary, TNF induces OCPs to produce VEGF-C through NF-κB, leading to significantly increased lymph...

Ngày tải lên: 09/08/2014, 10:21

... Bordron A, Dueymes M, Levy Y, Jamin C, Leroy JP, Piette JC, Shoenfeld Y, Youinou PY: The binding of some human antien- dothelial cell antibodies induces endothelial cell apoptosis. J Clin Invest 1998, ... terminology of DSM-IV [20]. Accordingly, in this study psychiatric diag- nosis was assigned following the DSM-IV. In our series, mood disorders and psychosis were observed in 29....

Ngày tải lên: 09/08/2014, 01:23

... destruction of bone structures in inflammatory diseases like RA. The measurement of cathe- psin K seems an inexpensive tool that is independent of CRP and shows only a weak correlation with the erythro- cyte ... cited. Abstract Cathepsin K is a cysteine protease that plays an essential role in osteoclast function and in the degradation of protein components of the bone mat...

Ngày tải lên: 09/08/2014, 06:22

... class with the highest degree of uncer- tainty in terms of its function, as this zinc finger type can also be involved in RNA binding or protein interactions. Functional assignment on the bases of ... This is in keeping with the results obtained by in situ hybridiza- tion [29,30], by which 94% of TFs (351 of 373 TFs in the database) are detected in the embryo. We we...

Ngày tải lên: 09/08/2014, 20:21

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Ngày tải lên: 07/08/2014, 18:21

... Ramsaransing et al. [9], indicate that Hcy increases may occur in MS in the absence of vitamin B12 and folate deficiency. Of particular interest is the fact that MS patients with increased Hcy had ... Gaubatz J, Yang F, Durante W, Chan L, Schafer AI, Pownall HJ, Yang X, Wang H: Hyperhomo- cysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I pro...

Ngày tải lên: 08/08/2014, 23:21

... the inten- sity of the L-PGDS bands was normalized by dividing them by the intensity of the β-actin band of the corresponding sample. 11β-PGF 2 α and PGD 2 assays The levels of 11β-PGF2α in hyaluronidase-treated ... Laboratories) containing hydrogen peroxide. The slides were counterstained with eosin. The specificity of staining was evaluated by using antibody Arthritis Researc...

Ngày tải lên: 09/08/2014, 01:22

... Deposition of ICs in the kidneys activates mono- cyte/macrophages by interacting with Fc receptor (FcγR) I and FcγRIII, initiating an inflammatory cascade of cytokines and chemokines. The release of ... role in phagocytosis, cytolysis, degranu- lation, and induction of inflammatory cytokines. Additionally, FcγRI-deficient mice display defective peritoneal monocyte infiltra...

Ngày tải lên: 09/08/2014, 01:22

... directly or by acting on their upstream kinases may have an increased effect when compared with a single cytokine inhibition. Conclusion These findings indicate that interactions between cyto- kines ... that blockade of these cytokines did not fully control arthritis in all patients. Our study demonstrated the potency of cytokine combination at low concentrations. Accordingly, combina...

Ngày tải lên: 09/08/2014, 01:23

... control mice with CIA reveal less inflammation/joint destruction in DBA-lpr/ lpr mice in spite of the same clinical score as that of control mice. The proinflammatory cytokines including TNF-α ... disease by destroying target tissues through induction of apoptosis of chondrocytes [33]. Alternatively, Fas could contribute to synovial hyperplasia by inducing proliferation o...

Ngày tải lên: 09/08/2014, 01:23