Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
... play pivotal roles in SLE. TLR7 and TLR8 bind to single-stranded RNA, TLR3 todouble-stranded RNA, and TLR 9 to DNA. These receptors are intracellular and are engaged by their ligands in a cyto-plasmic ... throughphagocyte production of transforming growth factor-β and IL-10. In addition, Gas-6 on apoptotic cells binding toreceptor kinases of Tyro 3 family (mer, tyro and axl) down-regulate inflammatory cytokines, ... isunknown and other inflammatory cytokines stimulated by TLRactivation, such as TNF-α and IL-6, may also play key roles.Cellular debris and immune clearanceA likely source of intracellular...
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Báo cáo y học: "CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls" docx
... the role played by CD14 in the innate immune response to PG-PS in vitro and in vivo, weassessed the inflammatory responses to PG-PS in CD14knockout primary macrophages and examined the develop-ment ... previously described in this model[22] (i.e. the infiltration of inflammatory cells into the syn-ovium, synovial hyperplasia, and fibrinous deposits; Fig.5a). Infiltration of inflammatory cells ... PG-PS-induced responses in vitro, including transient increase in intracellular calcium, activation of nuclear factor-κB, and secretion of the cytokines tumor necrosis factor-α and interleukin-6,...
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Báo cáo y học: " Eph Receptors and Ephrin Signaling" pps
... region an ephrin-binding domain and two fibronectin type III repeats, and an intracellular region containing a tyrosine kinase domain, a SAM domain and a PDZ binding domain. EphrinA ligands are attached ... and Eph A receptors and ligands have been implicated in synaptic plasticity, and play a role in repair of the nervous system following injury [30-32]. Cancer Eph receptor and ephrin ligand ... via Ryk, a Wnt receptor containing an inactive tyrosine kinase domain. Ryk can associate with EphB2 and EphB3, resulting in tyrosine phos-phorylation [23]. EphB receptors can also directly as-sociate...
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Báo cáo y học: "Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis" pptx
... link between the innate immune system and theadaptive immune system.IntroductionPattern recognition receptors (PRRs) are a family of receptors of the innate immune system binding to conserved ... CD4-peridinin chlorophyll protein mAbs and CD28-phycoerythrinmAbs and were permeabilized with 0.05% Tween 20 to stainintracellularly with fluorescein isothiocyanate-conjugated anti-perforin mAbs ... therelease of proinflammatory cytokines and leads to a higherexpression of TLR2. In ankylosing spondylitis (AS), as in other immune- mediateddiseases, an unusual proinflammatory and cytotoxic CD4+...
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Báo cáo y học: "Ozone Therapy and Hyperbaric Oxygen Treatment in Lung Injury in Septic Rats"
... affected initially, and sepsis leads to severe injury in lung tissue [5]. It has been shown that pericytes in lung tissue produce proinflammatory cytokines in response to lipopolysaccharide ... and clinical studies in animal models and human beings are needed to un-derstand molecular elements, ligand and receptors, involved in the mode of action of ozone and HBO. Finally, according ... activities and serum proinflammatory cytokine (TNF-α, IL-1β) le-vels were evaluated by enzyme linked immunosor-bent assay (ELISA) using commercially available kits according to the manufacturer’s instructions...
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Báo cáo y học: "Physical Exercise and Quality of Life in Breast Cancer Survivors" potx
... quality of life (QOL) by maximising functions affected by the disease and its therapy. Preliminary research suggests that exercise may be an effective intervention for enhancing QOL in cancer ... preliminary evidence for the safety, feasibility, and efficacy of exercise training in breast cancer survivors. The aim of this study was to assess the association between physical exercise and ... weight gain and inactivity secondary to treatment. The reduction in cardiopulmonary capacity may lead to reductions in quality of life [25, 26]. Research has provided preliminary evidence...
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Báo cáo y học: "Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures" doc
... is an inflammatory disease involving joints and othersystems including salivary glands. To assess NO production in RA patients, we compared levels of serum, urine, and salivarynitrite and nitrate ... NO in the pathogenesis ofjoint inflammation. Rodents in animal models of arthritis gener-Figure 3NOx/creatinine ratios in urine and serumNOx/creatinine ratios in urine and serum. Urine and ... urine constitutes 50 to 60% of the totalbody clearance of these compounds, with the remainingamounts being eliminated in unknown proportions by the exo-crine glands and by the respiratory and...
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Báo cáo y học: " T cells and post menopausal osteoporosis in murine models" doc
... in elucidating thecrosstalk between the immune system and bone and in uncovering the mechanism by which sex-steroids, infection and inflammation lead to bone loss by disregulating Tlymphocyte ... approximately50% of the increase in the number of T cells in the periphery,while the remaining 50% is due to enhanced peripheralexpansion. Similarly, thymectomy decreases by approximately50% the ... lymphopoietic cytokine and inducer of bone destruction in vivo [22]. IL-7 is producedprimarily by bone marrow stromal cells and OBs, but themechanism by which ovx increases IL-7 production and...
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Báo cáo y học: "Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells" pdf
... leucopenia,thrombocytopenia and C3/C4 decrease. IFIT4 protein waslocalized exclusively to the cytoplasm, and it was significantlyupregulated by IFN-α in normal PBMCs. To determine the roleplayed by IFIT4 in ... theSLEDAI-2K in 108 SLE patients (r = 0.0574, P > 0.05; Figure2j).IFIT4 protein is expressed predominantly in immune tissues and cells, and exclusively localized in the cytoplasmIFIT4 was examined ... manifesta-tion, severity and activity or even organ damage.IFIT4 was found to be predominantly expressed in immune tis-sues and cells, indicating a potential role for IFIT4 in immune response. Both...
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Báo cáo y học: "Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4" pot
... to joint inflammation by distinct pathways, one com-pletely dependent on IL-17 and the other only partially medi-ated by IL-17 (Figure 6a). The cytokine responses within thearthritic joints ... striking elevation of IL-17 (Figure 3c). These dataprovide insight into the heterogeneity of systemic as well asjoint-specific immune events underlying inflammatory arthritis.Another intriguing ... altering the cytokine milieu, phenotypeof Th17 cells, and/ or by directly inhibiting bone and cartilagedamage.Competing interestsThe authors declare that they have no competing interests.Authors'...
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