Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx

... play pivotal roles in SLE. TLR7 and TLR8 bind to single-stranded RNA, TLR3 to double-stranded RNA, and TLR 9 to DNA. These receptors are intracellular and are engaged by their ligands in a cyto- plasmic ... through phagocyte production of transforming growth factor-β and IL-10. In addition, Gas-6 on apoptotic cells binding to receptor kinases of Tyro 3 family (mer, tyro and...

Ngày tải lên: 09/08/2014, 10:21

... the role played by CD14 in the innate immune response to PG-PS in vitro and in vivo, we assessed the inflammatory responses to PG-PS in CD14 knockout primary macrophages and examined the develop- ment ... previously described in this model [22] (i.e. the infiltration of inflammatory cells into the syn- ovium, synovial hyperplasia, and fibrinous deposits; Fig. 5a). Infilt...

Ngày tải lên: 09/08/2014, 01:23

... region an ephrin-binding domain and two fibronectin type III repeats, and an intracellular region containing a tyrosine kinase domain, a SAM domain and a PDZ binding domain. EphrinA ligands are attached ... and Eph A receptors and ligands have been implicated in synaptic plasticity, and play a role in repair of the nervous system following injury [30-32]. Cancer Eph r...

Ngày tải lên: 08/08/2014, 17:20

... link between the innate immune system and the adaptive immune system. Introduction Pattern recognition receptors (PRRs) are a family of receptors of the innate immune system binding to conserved ... CD4- peridinin chlorophyll protein mAbs and CD28-phycoerythrin mAbs and were permeabilized with 0.05% Tween 20 to stain intracellularly with fluorescein isothiocyanate-conjugat...

Ngày tải lên: 09/08/2014, 07:20

... affected initially, and sepsis leads to severe injury in lung tissue [5]. It has been shown that pericytes in lung tissue produce proinflammatory cytokines in response to lipopolysaccharide ... and clinical studies in animal models and human beings are needed to un- derstand molecular elements, ligand and receptors, involved in the mode of action of ozone and HBO. F...

Ngày tải lên: 25/10/2012, 11:18

... quality of life (QOL) by maximising functions affected by the disease and its therapy. Preliminary research suggests that exercise may be an effective intervention for enhancing QOL in cancer ... preliminary evidence for the safety, feasibility, and efficacy of exercise training in breast cancer survivors. The aim of this study was to assess the association between physical exerci...

Ngày tải lên: 08/08/2014, 16:23

... is an inflammatory disease involving joints and other systems including salivary glands. To assess NO production in RA patients, we compared levels of serum, urine, and salivary nitrite and nitrate ... NO in the pathogenesis of joint inflammation. Rodents in animal models of arthritis gener- Figure 3 NOx/creatinine ratios in urine and serumNOx/creatinine ratios in urine and...

Ngày tải lên: 09/08/2014, 08:22

... in elucidating the crosstalk between the immune system and bone and in uncovering the mechanism by which sex-steroids, infection and inflammation lead to bone loss by disregulating T lymphocyte ... approximately 50% of the increase in the number of T cells in the periphery, while the remaining 50% is due to enhanced peripheral expansion. Similarly, thymectomy decreases by appr...

Ngày tải lên: 09/08/2014, 10:20

... leucopenia, thrombocytopenia and C3/C4 decrease. IFIT4 protein was localized exclusively to the cytoplasm, and it was significantly upregulated by IFN-α in normal PBMCs. To determine the role played by IFIT4 in ... the SLEDAI-2K in 108 SLE patients (r = 0.0574, P > 0.05; Figure 2j). IFIT4 protein is expressed predominantly in immune tissues and cells, and exclusively loc...

Ngày tải lên: 09/08/2014, 10:23

... to joint inflammation by distinct pathways, one com- pletely dependent on IL-17 and the other only partially medi- ated by IL-17 (Figure 6a). The cytokine responses within the arthritic joints ... striking elevation of IL-17 (Figure 3c). These data provide insight into the heterogeneity of systemic as well as joint-specific immune events underlying inflammatory arthritis. Another intr...

Ngày tải lên: 09/08/2014, 14:22