Báo cáo y học: " Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus" pptx

... illustrating the possible role of RNP1 motif in the initiation of T-B cell spreading pathway (adapted from [13]). Epitopes containing the RNP1 motif (in dark blue) are presented to specific T cells ... spread- ing), then proceeds in an ordered manner to other proteins containing the RNP1 motif, and finally, to proteins that do not contain any RNP1 motif but are...

Ngày tải lên: 09/08/2014, 10:21

... a 1 -antitrypsin, a 1 -antichymotrypsin, and anti- thrombin III resulted in an increased conformational stability and a decreased specific inhibitory activity [23,24]. Lys335, localized in b strand 5A, ... chains of the amino acids in positions 53 and 56 in a helix B, 186 in b strand 3A, and position 334 in b strand 5A (Fig. 1; the numbering of amino acids in PAI-1 is...

Ngày tải lên: 22/02/2014, 07:20

... Jarisch R: Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yel- low jacket venom in patients with stinging-insect allergy. J Allergy Clin Immunol 2001, ... hymenoptera venom allergy: guidelines for clinical practice. Allergy 2005, 60:1459-70. 7. Modrzyeski M, Zawisza E: Possible induction of oral allergy syn- drome during specific im...

Ngày tải lên: 08/08/2014, 21:20

... University School of Medi- cine and Moi Teaching and Referral Hospital (Eldoret, Kenya) and the Institutional Review Board of the Indiana University School of Medicine (Indianapolis, Indiana). Informed ... was obtained for key informant inter- views, and all clinical investigation was conducted accord- ing to the principles expressed in the Declaration of Helsinki. Study S...

Ngày tải lên: 25/10/2012, 10:31

... educts, intermediates, and products in order to answer questions about in vivo protein localizations and interactions as well as about cell trafficking and migration activity of stem cells for instance. ... cor- responding tetrazine 6, which in turn reacts with a mixture of the dansyl derivative and the N-ethyl-diisoproylamine and the dansyl sulfamidoethylamine to t...

Ngày tải lên: 25/10/2012, 11:00

... principal mechanism of action of all NSAIDs is the inhibition of the biosynthesis of prostaglandins by blocking the activity (selectively and/ or non-selectively) of two isoforms of cyclooxygenase ... against indomethacin-induced intestinal ulceration in the rat. Gastroenterology. 1985; 89: 86-91. 6. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of act...

Ngày tải lên: 26/10/2012, 08:57

... protein that is present in yeast and Escherichia coli and in mammalian cell types. In higher eukaryotes, it removes an intracellular H + and exchanges it for an extracellular Na + , thereby protecting ... in overexpressing integral membrane proteins. In this study, we examined the behavior of the protein expressed in mammalian cells to gain insights into its character...

Ngày tải lên: 08/03/2014, 16:20

... 5 HLA-B27/Chlamydia peptide tetramer staining and intracellular cytokine staining in patient no. 6HLA-B27/Chlamydia peptide tetramer staining and intracellular cytokine staining in patient no. 6. When synovial ... weeks in the presence of IL-7 and IL-15. Subsequently, FACS analysis for intracellular cytokine staining for IFN-γ performed after restimulation of this cell l...

Ngày tải lên: 09/08/2014, 01:24

... roles in bone physiology and arthritis are most clearly defined, but the biology of the remaining family members promises to be a fascinating emerging story within the field of ‘high numbered’ cytokines. Interleukin-17 ... a Review Biology of recently discovered cytokines: Interleukin-17 – a unique inflammatory cytokine with roles in bone biology and arthritis Sarah L Gaffen Dep...

Ngày tải lên: 09/08/2014, 01:24

... reproducibility of measuring cytokine and cell adhesion molecule staining by DIA was reported to be within 10% [8], no formal studies investigating intrarater and inter-rater variability have yet been ... proteins, such as cytokines and chemokines. Conclusion In conclusion, the findings of the present study show the relia- bility of ST analysis using a DIA system for the eva...

Ngày tải lên: 09/08/2014, 06:23