Báo cáo khoa học: " Simultaneous integrated boost of biopsy proven, MRI defined dominant intra-prostatic lesions to 95 Gray with " pot
Báo cáo khoa học: " Simultaneous integrated boost of biopsy proven, MRI defined dominant intra-prostatic lesions to 95 Gray with " pot
... OncologyOpen AccessResearch Simultaneous integrated boost of biopsy proven, MRI defined dominant intra-prostatic lesions to 95 Gray with IMRT: early results of a phase I NCI studyAnurag ... AbstractBackground: To assess the feasibility and early toxicity of selective, IMRT-based dose escalation (simultaneous integrated boost) to biopsy proven dominant intra-prostatic lesions visible on MRI. Methods: ... plans which gave 78 Gy to the prostate with IMRT plans giving 70 Gy to the whole prostate whilegiving a 90 Gy simultaneous integrated boost to a singleMR -defined dominant intra-prostatic lesion...
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Báo cáo khoa học: "Simultaneous integrated boost radiotherapy for bilateral breast: a treatment planning and dosimetric comparison for volumetric modulated arc and fixed field intensity modulated therapy" ppsx
... 25fractions (to keep treatment time limited to five weeks) of 2.0 Gy to entire breast with a simultaneous integrated boost of 2.4 to the tumour bed. This fractionation has yet to be proven to be clinically ... dosimetry tool in our centre for pre-treatmentverifications. With GLAaS no additional phantom has to be used and, for RapidArc, the detector rotatestogether with the gantry generating a sort of collapsedor ... referred to original publications fordetails [5,6]. To minimise the contribution of tongue andgroove effect during the arc rotation and to benefit fromleaves trajectories non-coplanar with respect...
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Báo cáo khoa học: "Growth and development of individual Douglas-fir in stands for applications to simulation in silviculture" potx
... results to fitEquation (8) were obtained with the incre-ment of the year preceding the last one.This could be attributed to a large part of determinacy of the growth of ... review of which is giv-en by Tomé and Burkhart, 1989) alwaysappear to be highly correlated with treesize, reducing their potential to improve theprediction of tree ... The new sample of trees, in site conditions similar to those of the first sample, included dominant, co- dominant, and intermediate trees, fromstands of initial density...
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Báo cáo khoa học: The hyperfluidization of mammalian cell membranes acts as a signal to initiate the heat shock protein response pptx
... loss of enzymatic activity correlates with the loss of its solu-ABFig. 5. Flow cytometric analysis of mitochondrial membrane poten-tial of K562 cells after heat treatment, or incubation with ... mediator of both mitogenic and stress signaling pathways, inresponse to subsequent growth factor stimulation [36].Given the importance of the plasma membrane in link-ing growth factor receptor ... cellular responses to heatshock, serum or growth factors is due to the release of the Ca2+-regulatory compound inositol 1,4,5-triphos-phate and coupled to the activation of phospho-inositide-specific...
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Báo cáo khoa học: "Feature-Rich Part-of-speech Tagging for Morphologically Complex Languages: Application to Bulgarian" docx
... affirmativeparticle, with a ratio of 12,035 to 543;• : 3rd person present auxiliary verb ( to be’)vs. particle (‘well’) vs. interjection (‘wow’), with a ratio of 9,136 to 21 to 5;• singular masculine noun with ... count form of a masculine noun, with a ratio of 6,437 to 1,592;• adverb vs. neuter singular adjective, with aratio of 3,858 to 1,753.Overall, the following factors should be takeninto account ... tag of the wordform, OldEnd isthe string that has to be removed from the end of the wordform, and NewEnd is the string that has to be concatenated to the beginning of the word-form in order to...
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Báo cáo khoa học: An alternative pathway of vitamin D2metabolism Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2and 17,20-dihydroxyvitamin D2 pot
... byanalysis of proton 1D, COSY and proton–carboncorrelation spectroscopy (HSQC) spectra of thiscompound and of parent vitamin D2(Fig. 2). Thehigh-order pattern in proton NMR of vitamin D2at5.19 ... spectra of vitamin D2metabolite 2 identified as 17,20-dihydroxyvitamin D2. (A) Proton spectra of metabolite 2. (B) Proton spec-tra of vitamin D2. (C) COSY of metabolite 2. (D) Proton–carbon ... formation of the vitamin D2metabo-lites, aminoglutethimide, a specific inhibitor of cyto-chrome P450scc in rat adrenal mitochondria [22,23],was added to the reaction mixture. The formation of the...
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Báo cáo khoa học: NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical b-toxin sequence but with a-like physiological activity doc
... basis of toxin specificity and molecular mechanism of actioncontinue to be of scientific interest: (a) to study ion channels,the target molecules of most known scorpion toxins, inorder to understand ... sodium currents of the neuroblastoma cell line F-11. (A-B) Na+currentelicited from a holding potential of )100 mV to the test potentials from )30 to +20 according to the protocol shown below ... analysis of charge distribution inNa+channelsThe receptor site 3 of Na+channels is surmised to beformed mainly of extracytoplasmic loops of the S3–S4segment of domain IV and, to a lesser...
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Báo cáo khoa học: The crystal structure of Thermoactinomyces vulgaris R-47 a-amylase II (TVA II) complexed with transglycosylated product potx
... structure of neopullulanasecomplexed with maltotetraose, the electron density corres-ponding to maltose was observed proximal to the position of Glc +2¢, and it was proposed that maltose may bea potential ... of Trp356 seems to trigger a rotational change of Tyr374. The side chain of Tyr374 is rotated from )51.1° to 149.8° in torsion angle of Cc–Cb–Ca–C on Tyr374without the steric barrier of ... )174.7° to 169.4° in torsion angle of Cc–Cb–Ca–C on Trp356. Thisconformational change makes a plane of its side chainparallel to the ring of Glc +2 and contributes to interaction with Glc...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
... theform of dimers [5,14]. To understand the importance of capsid protein–protein contacts for the stability of coat protein, we determined the stability of dlFG andcompared it with the stability of ... chang-es were analyzed by variation of spectral center of mass of trypto-phan emission in the absence of bis-ANS for (m) dlFG, (r ) sc-dlFG.and in the presence of bis-ANS for (e) sc-dlFG and the ... center of mass and by lightscattering. In contrast with the effects of chemicalagents, we found that high pressure was able to pro-mote only small changes in the spectral center of mass of the...
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Báo cáo khoa học: Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation potx
... sites.Remarkably, the total number of MIZ-1c sites is signi-ficantly increased in the region )1000 to )501 bp of target genes with decreased expression, when compared to the number of sites in the ... expandedthis strategy to gain general insights into the regulation of promoters of potential target genes of the Wnt path-way, which we identified by microarray screening.ResultsEvaluation of cell modelsAt ... transfection of APCwt. In reportergene assays of RK13 cells the Wnt pathway was activated bythe addition of 20 mm LiCl to the medium.Analysis of regulatory gene regionsWe screened the regions )3000 to...
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