Báo cáo khoa học: " Comparison of direct machine parameter optimization versus fluence optimization with sequential sequencing in IMRT of hypopharyngeal carcinoma" pptx

... Oncology Open Access Research Comparison of direct machine parameter optimization versus fluence optimization with sequential sequencing in IMRT of hypopharyngeal carcinoma Barbara Dobler*, Fabian ... [20-29]. The aim of this study is to compare the direct machine parameter optimization versus fluence optimization with subsequent leaf sequenc...

Ngày tải lên: 09/08/2014, 10:21

... proteins, and binding of the toxin to these claudins leads to rapid cytolysis of cells [26]. Preclinical studies have suggested that Clostridium perfringens enterotoxin may be effective against ... with LC-MS ⁄ MS, we examined the expression status of several of the identified proteins using western blotting. These repre- sentative proteins were selected based on changes of more th...

Ngày tải lên: 16/02/2014, 15:20

... Whereas induction of ctt1 + and apt1 occurred in all ubiquinone-deficient strains, induction of gpx1 + was not observed in any of the tested strains (Fig. 6). However, in the wild-type strain treated ... Induction of ctt1, encoding catalase, and apt1, encoding a 25 kDa protein, but not that of gpx1, encoding glutathione peroxidase, was indistinguishable in four ubiquinone-defi...

Ngày tải lên: 18/02/2014, 14:20

... those involved in substrate binding by side chain–side chain interactions, and part of a g iven subsite is indicated by the numbers under the boxes (i.e. 1, S 1 binding site; 2, S 2 binding site, etc.). ... that specificity of the enzyme might be altered so that it would prefer Tyr instead of Phe in its S2 pocket by replacing Val209 with Ser. In principle, this mutation would inc...

Ngày tải lên: 19/02/2014, 16:20

... crucial in scientific discovery’, the pioneering work by Swanson on hypo- thesis generation [299] is mainly credited with sparking interest in text mining techniques in biology. Text mining aids in ... finding it again in a principled way, visualizing it, sharing it, running it, analysing the results of the run, comparing them with experimental data, finding models that can creat...

Ngày tải lên: 07/03/2014, 12:20

... arranged in line to bind with the ice crystal [29]. In fish AFGP, Thr is conjugated with a disaccharide that is directly involved in ice binding [26]. Participation of Thr in ice binding was also ... ice-binding ability of the glycan part of AnpAFP. Direct involvement of gly- can in ice binding has been suggested only for fish AFGP consisting of an -Ala-Thr-Ala- repeat...

Ngày tải lên: 22/03/2014, 21:20

... labelling of proteins RNases were labelled with the Alexa Fluor 488 fluorophor, in accordance with the manufacturer’s instructions. To 0.5 mL of a 2 mgÆmL )1 protein solution in NaCl ⁄ Pi, 50 lL of ... the unbounded protein, whereas the pellet represents the insoluble fraction containing the PGN bound protein. (B) Scatchard plot and the corre- sponding binding curve of RNase 7...

Ngày tải lên: 22/03/2014, 21:20

... above, the histidine residue in fragment (52– 53) could b e involved in cross-linking, and an interestin g possibility is that t his residue is available for coordination in the recombinant enzyme ... produced in the natural host contains a covalent modification, probably an intrachain cross-link involving a residue in the 52–55 region and a residue in the 215–223 region. A tyrosin...

Ngày tải lên: 23/03/2014, 12:20

... Multidi- mensional Scaling. Sage, Beverly Hills. Joseph Kruskal. 1983. An overview of sequence comparison. In David Sankoff and Joseph Kruskal, editors, Time Warps, String Edits and Macromolecules: ... Theory and Practice of Sequence Comparison, pages 1-44. Addison- Wesley, Reading, Mass. -John Nerbonne and Wilbert Heeringa. 1999. Computational comparison and classificati...

Ngày tải lên: 24/03/2014, 03:20

... Tyr303 performing a specific HB interaction (Fig. 5C). Amino acid residues involved in the interactions with QZ59 compounds in the homology model of human P-gp The analysis of the residues involved in the interac- tions ... specific interactions can be outlined. The residues in the ligand-binding sites in Fig. 6. (A) A front overview of the P-gp binding cavity with the inhib...

Ngày tải lên: 29/03/2014, 22:21