Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc

... rise to proteins defective in ATM signalling in vivo [24]. Studies of linkage disequilibrium (LD) patterns of the ATM gene have revealed low recombination and extensive LD span- ning the whole gene, ... location of the identified variants along the gene as well as the exons rel- ative to the domains of the protein described by [17], such as the P...

Ngày tải lên: 09/08/2014, 10:21

... Margaritora 1 and Pierluigi Granone 1 Abstract Recent efforts to improve survival in patients with locally advanced esop hageal carcinoma have combined both systemic and local therapy. However, the ... correct evidence and agreed guidelines we consider the results from [1] of significant clinical value and concur in advocating for further evidence stemming from large s...

Ngày tải lên: 09/08/2014, 01:24

... not found in the samples of D. simulares studied here, since the linkage disequilibrium between the two most frequent alleles, analogous to the predominant allels in D. melanogaster ... of 36, or 8 %). In both cases, these are the kind of sampling variations that we would expect if there were no disequilibrium. The 36 ! produc...

Ngày tải lên: 09/08/2014, 22:22

... common

Ngày tải lên: 09/08/2014, 22:22

... obtained in vivo with the endocannabinoid transporter inhibitor AM404 [38] and with the FAAH inhibitor URB597 [39], thus suggesting the contribution of anandamide to the beneficial effects of CBs ... measure the brain levels of the endocannabinoids AEA and 2-AG and (c) to explore the changes in gene expression of CB1 and CB2 receptors. Earlier reports ha...

Ngày tải lên: 07/03/2014, 03:20

... conformational change in the extracellular domain, leading to an increase in affinity, thereby promoting integrin–ligand interactions [2]. In turn, clustering of integrins gene- rates a series of intracellular ... though they bind to distinct classes of surface receptor. This raises the ques- tion of the molecular basis of adhesion to these ligands and whether t...

Ngày tải lên: 16/03/2014, 12:20

... disease) gene at the androgen receptor in 1991 [1], followed by the Huntington’s disease (HD) gene in 1993 [2], and the cloning of the spinocerebellar ataxia type 1 gene [3], the expanded polyglutamine ... SCA1 pointing to serine kinase inhibition as a therapeutic strategy, and clini- cal success with the treatment of SBMA by leupro- relin, underscore the imp...

Ngày tải lên: 23/03/2014, 07:20

... has to be responsive to meaningful changes in health in the patient population under investigation. The aim of this study was to investigate the responsiveness of the EQ-5D in breast cancer patients ... were included in the trial after finalizing treatment and after giving written informed consent. Treatment included sur- gery and/ or radiotherapy and/ or...

Ngày tải lên: 18/06/2014, 19:20

... OF would lead to an increase in the numbers of individuals to be selected and this together with the smaller effect of the major gene would retard the fixation of the ... reduction in the weight given to the major gene relative to the polygenes, resulting in a greater intensity of selection applied to the polygenes...

Ngày tải lên: 09/08/2014, 18:21

... with other transmembrane proteins and regulate post-ligand binding events, including integrin- mediated adhesion strengthening. The c-terminus of CD81, CD151, and other tetraspanins meet the criteria ... expressed in a claudin-7 background. Of the 5 residues that differ between the claudin-1 and claudin-7 in the n-terminal 1/ 3 of ECL1, 2 were found to be important...

Ngày tải lên: 12/08/2014, 04:21