Báo cáo y học: "Src kinase inhibition promotes the chondrocyte phenotype" ppsx
Báo cáo y học: "Src kinase inhibition promotes the chondrocyte phenotype" ppsx
... chondrocyte differentiation. Primary chondrocyte cultures are a good model in which to study chondrocyte physiology because they are closer to the in vivo chondrocyte phenotype than are trans- formed ... activity. Figure 2 Src kinase activity regulates chondrocyte cell numbersSrc kinase activity regulates chondrocyte cell numbers. Primary mouse chondrocytes were incubated f...
Ngày tải lên: 09/08/2014, 10:21
Báo cáo y học: "Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions" pdf
... with tap water and UHQ water. Synthesis of the Copolymer Poly(N-isopropylacrylamide) copolymer (PNIPAAm) was synthesized by free radical polymerization following the procedures as reported with ... by freeze-drying before use. Hydroxypropyl methacrylate (HPM) and 3-trimethoxysi- lylpropyl methacrylate (TMSPM, the cross-linking agent) were purchased from Aldrich and used as sup- plied....
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "BACE-1 inhibition prevents the g-secretase inhibitor evoked Ab rise in human neuroblastoma SH-SY5Y cells" ppsx
... responsible for the synthesis of the inhibitors used in the study. ME designed the plasmids used for transfection of the cells. EL organized the study, participated in the study design and revised the manuscript. ... like LY450139 could have advantages by preventing the Ab rise. Authors’ contributions AJ carried out the experiments in SH-SY 5Y cells, participated in the...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
... activation of tyrosine kinase Normally the level of cellular tyrosine kinase phosphorylation is tightly controlled by the antagonizing effect of tyrosine kinase and tyrosine phosphatases. There are ... non receptor tyrosine kinase activity [4], and the finding of EGFR, the first receptor tyrosine kinase paved the way to the understanding of the role and significanc...
Ngày tải lên: 03/11/2012, 09:57
Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
... difficulties entering the S phase. The reason for the accumulation of cells in the G 1 phase may be due to the slightly lower kinase activity of the (S > A) 6 mutant Rio1p kinase during the G 1 phase ... phosphorylated in vivo to give a biologically fully active Rio1p kinase. The yeast strain carrying the mutant (S > D) 6 allele behaved indistinguishably from wild-...
Ngày tải lên: 18/02/2014, 16:20
Báo cáo Y học: DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells ppt
... the kinase domain of DAP kinase [20±22], a lso phosphorylates the regulatory light chain of myosin II the phosphorylation sites being threonine 18 and serine 1 9 [22]. In this study, the synthetic peptide, ... investigated the viability of PC12 cells overexpressing the wild-type DAP kinase, t he DCaM-DAP kinase m utant (a c onstitutively active kinase mutant), the K 42A...
Ngày tải lên: 24/03/2014, 00:21
Báo cáo y học: " Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats" pps
... Neuroanat 2005, 29:127-136. 34. Hayashi Y, Nishio M, Naito Y, Yokokura H, Nimura Y, Hidaka H, Watanabe Y: Regulation of neuronal nitric-oxide synthase by calmodulin kinases. J Biol Chem 1999, 274:20597-20602. 35. ... microinjection of the test agent into NTS. The BRR response was represented by the ratio of the peak magnitude of reflex bradycardia to the peak magni- tude of phe...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats" pdf
... Myocardial protection by the leukotriene synthesis inhibitor BAY X1005: Importance of transcellular biosynthesis of cysteinyl-leukotrienes. J Pharmacol Exp Ther 1996, 276:335. 27. Takamatsu Y, Shimada K, ... leukotriene biosynthesis indirectly by a mechanism through the binding of a membrane bound 5-lipoxygenase-activating protein (FLAP), thereby inhibiting the translocation and activa...
Ngày tải lên: 10/08/2014, 09:21
Báo cáo y học: "Rho kinase inhibitors Y27632 and H1152 augment neurite extension in the presence of cultured Schwann cells" pdf
... This pyridine derivative is the oldest syn- thesised and reported specific inhibitor of Rho -kinase family enzymes. Y2 7632 inhibits ROCK activity by com- petitive binding with ATP to the catalytic ... that the ROCK inhibitors Y2 7632 and H1152 altered the morphology of the SC. These changes were similar to those observed by Melendez et al [15]. They also described a shortening o...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: "Bench-to-bedside review: The MET syndrome – the challenges of researching and adopting medical emergency teams"
... signs were judged by nurses to be ‘usual for the patient’. These commonly included mild hypoxaemia, hypercarbia, and hypotension. As the MET call criteria depend heavily on physiological alteration ... data [52-56]. Inherent within this type of evidence is the lack of rigour and generalisability. Furthermore, the magnitude of the effect of the MET may be influenced by institution-...
Ngày tải lên: 25/10/2012, 10:35