Báo cáo y học: "Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes" pps

... one of which is N-acetylation; the result- ing N-acetylglucosamine can modify several proteins by cou- pling itself to the serine or threonine residues of those proteins. These include kinases, ... subunit, namely p65 (data not shown). The decreased phosphorylation MAPKs may be explained by the role played by glucosamine in O-glycosylation of some proteins. Glucosamine, when it ente...

Ngày tải lên: 09/08/2014, 10:21

... expression by synovial lining cells in zymosan-induced arthritis (ZIA) joints of MIF -/- miceDecreased MMP-2 expression by synovial lining cells in zymosan-induced arthritis (ZIA) joints of MIF -/- ... results in a twofold increase in MMP-2 production. In addi- tion, MIF enhances the gelatinase activity of RA synovial fibroblast-secreted proteins. Zymography analysis demon- st...

Ngày tải lên: 09/08/2014, 08:22

... chemical-genetics system to modulate the activity of a protein kinase by mutating an amino acid residue in its ATP-binding pocket (the ‘gate- keeper’ residue), allowing the resulting kinase - often called ... around proteins involved in RNA metabolism. Proteins identified in this screen are labeled in red. A solid line between two proteins indicates a direct interaction; an ar...

Ngày tải lên: 09/08/2014, 23:20

... cleavage by subtilisin between the prodomain and the target protein, thus releasing the target protein in its native form, begin- ning with the initiator methionine. Cloning of Rv0948c and MT0975 ... MtCM Cells from 1 L of induced culture of BL21(DE3) harboring pG58–Rv0948c (encoding either the 105 amino acid protein or the 90 amino acid protein) were suspended in 40 mL of...

Ngày tải lên: 17/03/2014, 17:20

... Glu- cosamine inhibits aggrecanase activity via suppression of gly- cosylphosphatidylinositol-linked proteins [17]. Furthermore, glucosamine has been shown to inhibit cytokine (interleukin-1 [IL-1])-induced ... chondrocyte and explant cul- tures [9-13]. These effects include stimulation of proteoglycan synthesis, inhibition of the degradation of proteoglycans, and inhibition of...

Ngày tải lên: 09/08/2014, 10:20

... 48 Psychosomatic medicine 13 39 Neurology 515 Social medicine 26 Psychology 26 Forensic psychiatry, internal medicine, gynecology, preventive medicine (1 each)13 Assessment Written examinations ... E-learning program for medical students; feasibility and evaluation of the acceptance in student training in child and adolescent psychiatry at the University Hospital in Ulm]. Z Kinder Jug...

Ngày tải lên: 25/10/2012, 10:06

... using original length of stay data and 2003 nursing day prices. Subsequently, total individual costs of care during the first six months were computed by holding the original ratio between inpatient ... central point representing a cost sav- ing of € 5,990 and a QALY gain of 0.51. The point esti- mate for the ICER is €11,685 saved per QALY gained; €14,211 and €7,745 saved per QALY gai...

Ngày tải lên: 25/10/2012, 10:35

... Int. J. Med. Sci. 2011, 8 http://www.medsci.org 468 copy owing to incomplete bowel preparation. The bleeding was controlled by #3-0 Vycryl intracorporeal suture, and the invagination of ... Moreover, invagina- tion of diverticulum can be easily performed using laparoscopy with a simple suture technique. There- fore, we decided to invaginate the diverticulum in- stead of using...

Ngày tải lên: 25/10/2012, 10:51

... arachnoid cyst; syringomyelia. Introduction The commonest type of arachnoid cyst that causes compression of the spinal cord and develop- ment of syringomyelia is the Chiari malformation type I ... J, et al. Symptomatic syringomyelia occurring as a late complication of posterior fossa medulloblastoma removal in infancy in a boy also suf- fering from scaphocephaly. Childs Nerv...

Ngày tải lên: 25/10/2012, 11:00

... Emulsified isoflurane preconditioning markedly attenuated hepatic I/R-induced lung injury in rats, which may be hopefully applied to the clinical treatment of organ injury caused by hepatic surgery, ... in some organs in vitro and in vivo. Isoflurane could down-regulate LPS-induced production of pro-inflammatory cytokines, including TNF-α and IL-1β in rats 32 . In this stu...

Ngày tải lên: 25/10/2012, 11:00