Báo cáo khoa học: " Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells" pdf

... transitions [24]. Our findings show that p53-p21 signaling pathways may be involved in DCQ radiosensitization under oxia but not under hypoxia in DLD-1 cells. This indicates that hypoxia enhances DCQ's potent ... 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells Wafica Itani 1 , Fady Geara 2 , Joe...

Ngày tải lên: 09/08/2014, 10:21

... food intake and energy expenditure in mammals, including regulation of fertility [ 2] and modulation of immune response [ 3]. These two actions might be interconnected in humans because leptin ... are suppressed by AEA in breast and prostate cancer cells [47], suggesting a possible functional link between Ikaros, AEA tone and Trk receptors in peripheral cells. Finally, it...

Ngày tải lên: 30/03/2014, 15:20

... in plasmin formation, to a decrease in plasmin binding or to a combination of the two. We demonstrate that both mAb 34D3 and mAb A10.2 inhibit plasmin binding to cells (Fig. 5A) and fibrin (Fig. 5B) in ... function. Blocking the kringle 1 lysine- binding site with monoclonal antibody 34D3 fully abolished binding and activation of Glu-plasminogen and prevented both fibrinolysis an...

Ngày tải lên: 20/02/2014, 01:20

... the tetracycline-resistance cassette into the HindIII site. pRS239 was obtained by inserting the tetra- cycline-resistance cassette into the HindIII site of pRS155, encoding glnK under the control ... bacteria. GlnK protein a ppears t o m ediate the nitrogen status of the cell by direct protein–protein interaction with NifL in A. vinelandii [25,26]; and in diazotrophs, w hich do n...

Ngày tải lên: 07/03/2014, 16:20

... Differences in the intrinsic fluorescence of pyruvate kinase incubated with and without ligands (K + ,Mg 2+ and phosphoenolpyruvate) have been reported previously, and it has been proposed that the distinct ... was initiated by introducing pyruvate kinase. Fluorescence experiments Fluorescence emission spectra of pyruvate kinase in 100% water and in various water/dimethylsulfox...

Ngày tải lên: 08/03/2014, 02:20

... antitrypsin with preprohepcidin, prohepcidin and mature hepcidin. Insert in pBT Insert in pTRG Growth on CTCK plates a Preprohepcidin a-1 Antitrypsin +++ Prohepcidin a-1 Antitrypsin +++ Hepcidin a-1 ... After binding hepcidin, ferroportin is internalized, phosphor- ylated, ubiquitinated and degraded by hepatocytes and macrophages. [18,19]. The action of hepcidin is differ- ent in...

Ngày tải lên: 16/03/2014, 01:20

... lg of protein was applied to SDS ⁄ PAGE under nonreduc- ing conditions, and analysed by silver staining as described in Materi- als and methods. Marker proteins and their corresponding molecular masss ... visualized by silver staining. Identification and analysis of proteins by MS The 22 and 42 kDa bands from one lane in a Coomassie Brilliant Blue-stained SDS ⁄ PAGE were...

Ngày tải lên: 16/03/2014, 04:20

... target of palytoxin [11,12], which, as verified in experiments involving in vitro translation and integration of the expressed proteins in membranes [13], is converted by the toxin into an ion channel ... latter findings, as the palytoxin-induced conductance was insensitive to 1 m M ouabain while being inhibited at low concentrations of orthovanadate. Similar findings showing a palytox...

Ngày tải lên: 17/03/2014, 11:20

... 2515–2527. 32 Kos J, Dolinar M & Turk V (1992) Isolation and char- acterisation of chicken L- and H-kininogens and their interaction with chicken cysteine proteinases and papain. Agents Actions ... cystatin has a high potential for inactivating cathepsin B, however, free cystatin is unable to enter the cells and inhi- bit intracellular proteolytic activity. Incorpora- tion of cy...

Ngày tải lên: 23/03/2014, 07:20

... doxycycline-inducible protein expression by just a single transfec- tion. pEBTetD contains an Epstein–Barr virus origin of replication for stable and efficient episomal propagation in human cell lines, ... ratio and the slope of the calibration curve, obtained by weighted linear regression. For radiotracer assays, protein was measured by the bicinchoninic acid assay [25] with bov...

Ngày tải lên: 23/03/2014, 09:21