Báo cáo khoa học: " CyberKnife® radiosurgery in the treatment of complex skull base tumors: analysis of treatment planning parameters" potx

... complications in the treatment of skull base lesions with adjacent critical structures. These generalprinciples have found acceptance in the treatment of othersites with radiation therapy [23,24].When ... calculate indices for each individual lesion. Of the remaining lesions, 46 were categorized into the complex, skull base tumor group. A complex skull base tumor was defined as one that completely ... physicist input the specific treatment criteria, limiting the maximum dose tostructures such as the optic chiasm and brainstem. The majority of the treatments were given in five fractions. In general,...

Tài liệu Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression proﬁling ppt

... [17]. The A and B iso-forms are typical members of the NR family, differingonly in the N-terminal end of the variable A ⁄ Bdomain. The third mosquito isoform, AaHNF-4C,lacks the greater part of ... femalemosquitoes. They isolated several clones that codefor a single protein. Interestingly, during the initialprocess of identifying the NR family members in the A. aegypti genome, we predicted two isoforms ... well as the sequences of the humanorthologs. When different isoforms were recovered,only the longest amino acid sequences that included the DNA binding, hinge and ligand-binding domainswere...

Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx

... interpretation in distinguish-ing interacting from noninteracting proteins. OneFig. 1. Schematics of library designs. The helical wheel diagram looks down the axis from the N-terminus to the C-terminus. ... date [20].AP-1 foldingFurther insight into the structural determinants of sta-bility arose by dissecting the folding pathway of fourJun-based leucine zipper variants that bind with highafﬁnity ... formed rather late in the folding pathway andtherefore exert their effect on the unfolding rate of pre-formed pairs [24]. In creating a mutant that containedmultiple e ⁄ g Arg-Glu pairings, dimers...

Tài liệu Báo cáo khoa học: Final steps in the catabolism of nicotine Deamination versus demethylation of c-N-methylaminobutyrate doc

... to the complete mineraliza-tion of the pyrrolidine ring of nicotine, which afteroxidation by 6-hydroxy-l-nicotine oxidase, is cleavedoff from the pyridine ring of nicotine in the form of CH3-4-aminobutyrate. ... expression of these genesdepends on the presence of nicotine in the growthmedium and we have determined the enzyme activities of the proteins. Our results demonstrate the presence of two pathways of ... pyrrolidine moiety of nicotine.Expression of the genes of these enzymes was dependent on the presence of nicotine in the growth medium. Thus, two enzymes of the nicotine regulon,c-N-methylaminobutyrate...

Tài liệu Báo cáo khoa học: Isochore structures in the chicken genome ppt

... Tnare the cumulative numbers of the bases A, C, G and T, respectively, occurring in the subsequence from the ﬁrst base to the n-th base in the DNA sequence inspected. Here, znis one of the compo-nents ... versa, indicating a mosaic structure of the chromosomes. A jump in the Àz0ncurve indicates an increase of the G + C con-tent; whereas a drop down in the Àz0ncurve indicates a decrease of the ... all the seg-ments obtained at t0¼ 100 without the constraint of the minimumlength in the draft genome sequence of chicken. (A) The length dis-tribution of all the obtained segments. The...

Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc

... investigate the develop-ment of neuropathology in SE [6]. Despite numerousstudies clearly indicating the importance of enzymeactivity in the epileptic phenomenon, the mechanismsby which these ... not die within 24 h of observation.Determination of lipid peroxidation and nitritecontentFor all of the experimental procedures, 10% (w ⁄ v) homo-genates of the area of the brain investigated ... results show an increase in nitriteformation after SE, suggesting that there is a possibleincrease in concentrations of ROS, which are ofteninvolved in neuronal damage [7,15]. Other studies haveshown...

Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf

... productive binding of steroid substrates: in the ﬁrst, a (small) sub population of enzyme bindsdirectly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactiveconformation. ... unusual in havingtwo histidine residues (rather than the His-Asn pairseen in OYE, MR and some of the other memberproteins; Fig. 1B) in the active site for ligand andsubstrate binding. For ... contain aHis-His pair, there has been no report of a systematic analysis of the contribution of each histidine residue tobinding and catalysis. Thus, to ascertain the role of each histidine...

Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx

... wild-type protein at 0 h). Nevertheless, itcould also be explained by changes in translation ormaturation of the protein. An increase was alsoobserved in the rate of degradation of the remainingmutant ... of the signaling event. In particular, the rapid degradation of signaling proteins by the protea-some ⁄ ubiquitin system appears to play an importantrole in the control of the duration of the ... after incubation with[35S]methionine may indicate an alteration in the rate of its degradation during the labeling period. In fact,only 15% of 35S-labeled mutant protein remains (vs.100% of...

Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc

... 14.635 lmolÆmin)1Æmg protein)1. The inset in (A) repre-sents the linear transformation of the curve. (B) Mg2+dependency wasdetermined as described in (A) in the presence of increasing concen-trations ... determined by incubating the diluted recombin-ant proteins in the standard reaction mixture in the presence of increasing concentrations of PPi(0.05–0.5 mM)at55°C.Data were ﬁt to the appropriate ... helminth parasite including the roundwormAscaris. To address this, we describe here the cloning,sequencing and heterologous expression in E. coli of a geneencoding PPase of A. suum. The amino...

Tài liệu Báo cáo khoa học: "Multimodal Generation in the COMIC Dialogue System" docx

... and control of the underlying applica-tion. Figure 1 shows screen shots of the COMICinterface.There are four main phases in the demonstra-tor. First, the user speciﬁes the shape of theirown ... Speech-plans: Generating evaluative responses in spoken dia-logue. In Proceedings of INLG 2002.Michael White. 2004. Reining in CCG chart realization. In Proceedings of INLG 2004.Michael White. ... decide what the system will show andsay in response to user input. The input to the 456 Output Coordination In addition to planning the presentation content asdescribed earlier, the ﬁssion...

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