Báo cáo y học: "The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice" docx

... heterozygous double congenic strain; and the Nss1 homozygous and Idd5 homozygous double congenic strain. The purpose of the present study was to monitor the influence of each of these two loci on the ... expression profiling has been on identifying genes in the two NOD derived congenic regions Idd5 and Nss1 that clearly cause the increase in si...

Ngày tải lên: 09/08/2014, 10:21

... 1A,B). The inhibition of insulin signalling in the liver is pri- marily reflected by the attenuation of the insulin-medi- ated inhibition of gluconeogenic gene expression. As Effect of TNFa on insulin ... maintenance of normal glu- cose homeostasis; they do so by regulating the gene expression of rate-limiting enzymes of gluconeogenesis and glycogenolysis,...

Ngày tải lên: 16/03/2014, 02:20

... activity of nitric oxide synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in ... immunoreactivity at 5days after in- duction of excitotoxicity (23). Increased formation of NO by stimulated activity of NOS depends upon a continuous supply of arginin...

Ngày tải lên: 26/10/2012, 09:07

... Shandong, China; 2. Department of Rehabilitation, Shandong Provincial Hospital affiliated to Shandong University, Jinan Shandong, China.  Corresponding author: Hong Chang, Department of General ... 4-20). Nine patients had their tumors within the head, 2 in the body and 7 in the tail of the pancreas. Notably one patient was demonstrated to have liver metastasis. The...

Ngày tải lên: 25/10/2012, 11:40

... the adenylylation of these compounds and the absence of synthesis of poly(A) by the E.colipoly(A) polymerase, we did not observed adenyly- lation of guanosine, GDP or Gp 4 G by the yeast enzyme. In ... activity of Gp n Gs as effectors of the synthesis of poly(A) Based on the above results, the effect of several diguanosine polyphosphates on the synthesi...

Ngày tải lên: 21/02/2014, 01:21

... property in common, namely that they contain a hydrogen-bond donor in wing2. This property is of general importance for the efficacy of the inhibitor. Substitution of the hydrogen-donating amide ... proximity of the mutation. This has mainly two consequences for the binding of NNRTIs: changed hydrophobic and electrostatic properties of the NNIBP. Changes in hydr...

Ngày tải lên: 18/03/2014, 01:20

... proteins were expressed and purified. Our results show that the fusion proteins were labile and only partially soluble in five of the constructs resulting in very poor yields. Intriguingly, in the ... of the constructs was retained. Therefore, the differing protein solubilities were inherent in the constructs and could not be modulated by varying the ambient grow...

Ngày tải lên: 23/03/2014, 21:20

... does the eGFR II. The conversion of the S-Creatinine by any of the algorithms we tested does thus not contribute to a more effective understanding of the kidney function. The uncertainty of ... drastically change the diagnostic power of the measurand. On the contrary, the algorithm will increase the uncertainty of the result and thus the diagnos...

Ngày tải lên: 08/08/2014, 16:23

... where, and when the genetic information will be used (gene expression) . These epigenetic changes generally involve DNA modification such as methylation and acetylation, histone protein modifications, ... pre-natally, and the u se of bo th questionnaires and physical examinations for obtaining information from the participants and their parents, information bias, if presen...

Ngày tải lên: 08/08/2014, 21:20

... labeling (Fig. 4). Effect of handling on BDNF immunoreactivity in the CA4 region of the hippocampusFigure 3 Effect of handling on BDNF immunoreactivity in the CA4 region of the hippocampus. Handling ... citation purposes) Effects of handling on the density of 5-HT1A receptors in the hippocampusFigure 4 Effects of handling on the density of 5-HT1A re...

Ngày tải lên: 08/08/2014, 21:20