Báo cáo y học: "NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor" docx

... article NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating ... involved in osteoclastogenesisEffect of dehydroxymethylepoxyquinomicin on serum factors involved in osteoclastogenesis. Effec...

Ngày tải lên: 09/08/2014, 10:21

... RELA-containing dimers for canonical and non-canonical sequences RELARELA RELAp50 RELAp52 Binding affinity (z-score) Binding affinity (K d ) Binding affinity (z-score) Binding affinity (K d ) Binding ... for a UV footprinting experiment. Finally, differences for in vitro binding potential as determined using binding affinities from EMSA-Seq and differences for in vivo binding as estab...

Ngày tải lên: 09/08/2014, 23:20

... the growing body of evidence indicating a role for Ang-2 as a mediator in critically illness, the value of Ang-2 as a predictive marker of outcome is poorly defined. The aim of this study was to investigate ... by various factors, including comple- ment, cytokines, fibrin, activated platelets and leucocytes, and changes in oxygenation or blood flow [8,15]. Orfanos and col-...

Ngày tải lên: 25/10/2012, 10:31

... normal renal function with Cr of < 1.3 mg/dL into those with normal and pseudo-normal renal function, resulting in the corresponding serum concentrations of digoxin. Key words: Cystatin ... participated in this study. The serum levels of Cys-C and Cr in the patients were higher than those in the healthy elderly subjects, but the increase of Cys-C was more predominan...

Ngày tải lên: 31/10/2012, 17:08

... decrease binding [57]. ATP hydrolysis or enzyme autophosphorylation, however, are not necessary for the formation of the palytoxin-induced channel because palytoxin produces K + efflux in yeast cells expressing ... K + -transporting capability. Finally, a dual function for the b2 isoform is also suggested by the fact that it is expressed in tissues that contain no b1 isoform, including...

Ngày tải lên: 24/03/2014, 00:21

... Modelling. 2. Operant conditioning or type II dependence according to Pavlovian theory. 3. Basic conditioning or type I, according the same theory. As far as modelling is concerned, the model of ... Meyer RE, Dolin- sky ZS, Rounsaville B: Types of alcoholics. I: evidence for an empirically derived typology based on indicators of vulnera- bility and severity. Arch Gen Psychiatry 19...

Ngày tải lên: 08/08/2014, 23:21

... modulation of histone deacetylase activity [39], or retinoyla- tion of kinases upstream of the ERK 1/2 pathway [47,48] could support the anti-inflammatory effect of other retinoids. Competing interests The ... to its inhibitory effect on Figure 2 Effect of retinoids on interleukin-1-beta (IL-1β)-induced expression of IL-6 in synovial fibroblastsEffect of retinoids on inte...

Ngày tải lên: 09/08/2014, 01:22

... The increased expression and activation of MMP-2 and -9, induced by C 2 -ceramide treatment of chondrocytes, is a novel finding and the significant inhibitory effects of 2-AP provide compelling ... after treatment of explants with 100 ng/ml TNF-α or 50 µM C 2 -ceramide in the presence or absence of the PKR inhibitor 2-AP (10 mM) and analysed by gelatin substrate zy...

Ngày tải lên: 09/08/2014, 01:23

... is influencing monocyte recruitment, survival, and/ or retention in the synovial joint. Alternatively, IFN-β may inhibit inflammatory cell infiltration indirectly, via suppression of FLS and/ or ... mainly anti-inflammatory properties. IFN-β downregulates the proinflammatory cytokines IL-1β and tumor necrosis factor α (TNF-α) and enhances IL-10 and IL-1 receptor antagonist pro...

Ngày tải lên: 09/08/2014, 01:23

... stimulation index (SI, defined as [ 3 H]thy- midine incorporation in the presence of antigen or Con A divided by [ 3 H]thymidine incorporation in the absence of anti- gen or Con A) of triplicate ... University, Utrecht, The Netherlands 2 Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht,...

Ngày tải lên: 09/08/2014, 06:22