Báo cáo y học: "NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor" docx
Báo cáo y học: "NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor" docx
... articleNF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating ... involved in osteoclastogenesisEffect of dehydroxymethylepoxyquinomicin on serum factors involved in osteoclastogenesis. Effect of dehydroxymethylepoxyquinomicin (DHMEQ) on serum levels of (a) osteoprotegerin ... cell-permeableNF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses expression of proinflammatory cytokines and ameliorates mouse arthritis. It remained unclear, however,whether DHMEQ directly affects...
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Báo cáo y học: " NF- B subunits RELB C-Rel RELA p50 p52 bound DNA b EMS" docx
... RELA-containing dimers for canonical and non-canonical sequencesRELARELA RELAp50 RELAp52Binding affinity(z-score)Bindingaffinity (Kd)Binding affinity(z-score)Bindingaffinity (Kd)Binding ... for a UV footprinting experiment.Finally, differences for in vitro binding potential as determined using binding affinities from EMSA-Seq and differences for in vivo binding asestablished by ... NF-Bconsensusandspecifi-city of binding for typicalexamplesofthesenovelsequences was validated by UV-laser footprinting.Finally, we examine the relationships between N F-B in vitro binding affinities (defined as binding...
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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"
... thegrowing body of evidence indicating a role for Ang-2 as amediator in critically illness, the value of Ang-2 as a predictivemarker of outcome is poorly defined.The aim of this study was to investigate ... by various factors, including comple-ment, cytokines, fibrin, activated platelets and leucocytes, and changes in oxygenation or blood flow [8,15]. Orfanos and col-leagues [25] and Ganter and ... correlate with the severity of illness asassessed by injury severity score [22], organ failure index [24],Acute Physiology and Chronic Health Evaluation (APACHE) IIscores and Sequential Organ...
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Báo cáo y học: "Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients
... normal renal function with Cr of < 1.3 mg/dL into those with normal and pseudo-normal renal function, resulting in the corresponding serum concentrations of digoxin. Key words: Cystatin ... participated in this study. The serum levels of Cys-C and Cr in the patients were higher than those in the healthy elderly subjects, but the increase of Cys-C was more predominant in the patients. ... Creatinine, Digoxin, Serum concentration, Heart failure, Renal clearance 1. Introduction Cystatin C (Cys-C) is a non-glycosylated cationic protein of 13.3 kDa, belonging to the cystatin superfamily...
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Báo cáo Y học: The sodium pump Its molecular properties and mechanics of ion transport potx
... decrease binding [57]. ATPhydrolysis or enzyme autophosphorylation, however, arenot necessary for the formation of the palytoxin-inducedchannel because palytoxin produces K+efflux in yeast cellsexpressing ... K+-transportingcapability. Finally, a dual function for the b2 isoform is alsosuggested by the fact that it is expressed in tissues thatcontain no b1 isoform, including pineal gland, photorecep-tor ... especi-ally of digitalis and its congeners, helps to increase muscularcontractility of the failing heart, possibly by indirectlyinducing an elevation in the Ca2+concentration in themyocardium....
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Báo cáo y học: "A short review on the aetiology and pathophysiology of alcoholism" ppt
... Modelling.2. Operant conditioning or type II dependence accordingto Pavlovian theory.3. Basic conditioning or type I, according the same theory.As far as modelling is concerned, the model of ... Meyer RE, Dolin-sky ZS, Rounsaville B: Types of alcoholics. I: evidence for anempirically derived typology based on indicators of vulnera-bility and severity. Arch Gen Psychiatry 1992, 49(8):599-608.14. ... state of mind and social influences are in constant interaction with brainneurobiology and pathophysiology. This disorder influences different sexes in different ways and causes major problems,...
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Báo cáo y học: "All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation" ppsx
... modulation of histone deacetylase activity [39], or retinoyla-tion of kinases upstream of the ERK1/2 pathway [47,48] couldsupport the anti-inflammatory effect of other retinoids.Competing interestsThe ... to its inhibitory effect onFigure 2Effect of retinoids on interleukin-1-beta (IL-1β)-induced expression of IL-6 in synovial fibroblastsEffect of retinoids on interleukin-1-beta (IL-1β)-induced ... expression in rat synovial fibroblastsby inhibiting ERK1/2 pathway and subsequent activation of AP-1 and NF-IL-6 independently of RAR.IntroductionRetinoids are natural or synthetic analogs of vitamin...
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Báo cáo y học: "α Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism" pps
... The increased expression and activation of MMP-2 and -9, induced by C2-ceramide treatment of chondrocytes, is a novel finding and the significant inhibitoryeffects of 2-AP provide compelling ... aftertreatment of explants with 100 ng/ml TNF-α or 50 µMC2-ceramide in the presence or absence of the PKR inhibitor 2-AP (10 mM) and analysed by gelatin substrate zymography. A standard known tocontain ... treatment of primary chondrocytes and chondrocyte cell lines results in increased apoptosis and caspase activity [43,44]. Sincewe have previously shown that TNF-α increases PACTprotein expression and...
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Báo cáo y học: "β Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis" ppt
... isinfluencing monocyte recruitment, survival, and/ or retention in the synovial joint.Alternatively, IFN-β may inhibit inflammatory cell infiltrationindirectly, via suppression of FLS and/ or ... mainly anti-inflammatory properties.IFN-β downregulates the proinflammatory cytokines IL-1β and tumor necrosis factor α (TNF-α) and enhances IL-10 and IL-1 receptor antagonist production by lymphocytes ... histologically 8 days after the onset of arthritis. Proteoglycan depletion was determined by safraninO staining. Expression of cytokines, receptor activator of NF-κB ligand, and c-Fos was evaluated...
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Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps
... stimulation index (SI, defined as [3H]thy-midine incorporation in the presence of antigen or Con Adivided by [3H]thymidine incorporation in the absence of anti-gen or Con A) of triplicate ... University, Utrecht, The Netherlands2Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The NetherlandsCorresponding ... dis-ease scores in comparison with 10 mg/ml Mt). Rats wereweighed and examined for clinical signs of arthritis in a semi-blinded set-up. Severity of arthritis was scored by gradingeach paw from...
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