... pathways: the primary processing pathway, and the amplification ‘ping- pong’ loop [5,6]. Mature piRNAs are loaded onto the PIWI subfamily of Argonaute proteins, and the amplifi- cation loop is ... functions in the suppression of transposon-mediated ‘canonical’ mutagenesis via the piRNA pathway. (a) Activated transposons can move from one site in a genome to another by the...
Ngày tải lên: 09/08/2014, 20:21
Báo cáo y học: "Is fibromyalgia a cardiovascular disease? A comment on Martinez-Lavin’s review ‘Stress, the stress response system, and fibromyalgia’" ppsx
... disease associated with CSM? Only time and more knowledge will tell. Letter Is fibromyalgia a cardiovascular disease? A comment on Martinez-Lavin’s review Stress, the stress response system, and fibromyalgia Francisco ... community has accepted FMS as a valid, unique clinical diagnosis and the main theory explaining it (the central sensitization model...
Ngày tải lên: 09/08/2014, 10:21
... was analyzed by a linear expansion least-squares algorithm and graphically using a least mean squares fit procedure. The rate constant errors were defined as the standard deviation. Thermal denaturation ... differences obtained from H. One explanation may be that H cannot exactly reflect the main changes during thermal denaturation. A second explanation may be that there are some s...
Ngày tải lên: 21/02/2014, 01:21
Báo cáo y học: "Is there a dysfunction in the visual system of depressed patients" pptx
... one can study the electrical and metabolic activity of the outer layers of the retina. During the adaptation of the retina to dark, the amplitude of the EOG gradually decreases, reaching a nadir ... Degeneration. Biol Psychiatry 1997:51S. 54. Van den Hoofdakker RH, Beersma DGM: On the Contribution of Sleep-Wake Physiology to the Explanation and the Treat- ment of D...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: "Etanercept versus etanercept plus methotrexate: a registrybased study suggesting that the combination is clinically more efficacious" pptx
... registry, the present study was performed using only data collected and analysed at the Karolinska and Huddinge Hospitals. The STURE database is maintained in the RAMONA soft- ware package (Carmona, ... of pain, and the physician global assessment all revealed statistically sig- nificantly better results for the combination therapy as compared with the monotherapy after 3...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal" ppsx
... antibodies and clinical manifestations is not required in SLE classification and diagnosis. For example, the previous presence of anti-dsDNA antibodies (by any assay) and accordingly a positive ANA test ... injury. Anti-dsDNA antibodies and lupus pathophysiology Anti-dsDNA antibodies and SLE pathophysiology are currently quite loosely connected in both classification and clini...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: " Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience" pdf
... questions than they answer. How do the effects of TNFα and IL-1β combine to alter the extracellular matrix of discs? Do they act in the same way in degenerated and herniated IVDs? Do they act in the ... receptor antagonist (IL-1ra) might be a good candidate to inhibit IL-1 activity. However, many questions need to be addressed before contemplating therapy in humans. IL-1 blockad...
Ngày tải lên: 09/08/2014, 10:21
Báo cáo y học: " Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs" docx
... (Bregs), regulatory DCs and suppressive macrophages on the one hand, and pro-inflammatory effector lymphocytes and monocyte-derived cells on the other, is likely to dictate the choice between tolerance and ... is an autoimmune disorder characterized by chronic systemic and synovial tissue inflammation that, if not therapeutically tackled, ultimately leads to bone and car...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Is a purpose of REM sleep atonia to help regenerate intervertebral disc volumetric loss" pdf
... citation purposes) stand clearly the gravitational influences on all adjacently associated mammalian structural tissues related to these muscles across day and night. The spine plays a founda- tional ... new hypothesis. That is, aquatic mammals are not under the same gravitational demands as are land mam- mals and do not require the same buttressing spinal mechanisms for stabi...
Ngày tải lên: 10/08/2014, 09:20
Báo cáo y học: " Is distortion of the bioprosthesis ring a risk factor for early calcificatio" docx
... from valve calcification. The mean time between the first operation and reoperation was 70 months (range 36 to 98 months). In all patients a chest radiography and coronary angio- graphy was performed ... Sierra Quiroga 1 , Anxo Martinez de Alegria 2 , Jose Manuel Suarez Peñaranda 3 Abstract Background: As the population ages, bioprosthesis are increasingly being used in cardiac va...
Ngày tải lên: 10/08/2014, 09:22