Báo cáo y học: "Skewed distribution of proinflammatory CD4+CD28null T cells in rheumatoid arthritis" docx
Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... medical emergency contacts outside hospitals in Norway - a prospective population based study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2010 18:9.Submit your next manuscript ... score was in the analyses cate-gorised as NACA 0-1 , indicating a patient either withno symptoms/injuries or in no need of medical treat-ment, NACA 2-3 , indicating need of medical helpwhere value ... possibleNACA 5 Acute vital (life threatening) dangerNACA 6 Acute cardiac or respiratory arrestNACA 7 DeathZakariassen et al. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2010,...
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Báo cáo y học: "α α Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis" pps
... haematoxylin and eosin stained sections.Immunohistochemistry for HIF-1 α and HIF-2 α expressionThe HIF- 1α and HIF- 2α proteins were detected usingESEE 122 (IgG1monoclonal antibody [mAb]; ... significant.ResultsHIF- α expression in synovial lining cellsHIF- 1α and HIF- 2α expression was both cytoplasmic and nuclear in arthritic synovial tissues (Fig. 1a,b). The medianpercentage of synovial lining cells ... expressing HIF-1 α and HIF-2 α proteins in normal, rheumatoid, and osteoarthritic synoviumNormal (n = 22) OA (n = 34) RA (n = 22)HIF- 1α HIF- 2α HIF- 1α HIF- 2α HIF- 1α HIF- 2α Minimum 0.00 0.00 20.00...
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Báo cáo y học: "Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage" docx
... of lipocalin-type prostaglandin D synthase (L-PGDS) protein in healthy and osteoarthritis (OA) cartilageExpression of lipocalin-type prostaglandin D synthase (L-PGDS) protein in healthy and osteoarthritis ... 7Effect of prostaglandin D2 (PGD2) on interleukin-1-beta (IL-1β)-induced upregulation of lipocalin-type prostaglandin D synthase (L-PGDS) expressionEffect of prostaglandin D2 (PGD2) on interleukin-1-beta ... Kijima Y, Matsu-ura Y, Urade Y, Hayaishi O: Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients. Proc...
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Báo cáo y học: " Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis" ppt
... than the thresholdcalcium concentration for PAD activity (approximatelyCommentary Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritisErik R Vossenaar and Walther ... in the inflamed synovium,especially in the synovial fluid. Because granulocytes havea lifespan of only about 3 days, they will die in largenumbers at the site of inflammation, which may triggerhistone ... were initially investigated, a recent follow up of that study [28] showed that citrullinated fibrin may also bepresent in synovial tissue of patients with other forms ofjoint inflammation. By...
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Báo cáo y học: "Fine mapping of genes within the IDDM8 region in rheumatoid arthritis" pot
... box-binding protein (TBP) amongst others. The aim of this study wasto fine map the IDDM8 region on chromosome 6q27, focusingon the genes in the region, to identify polymorphisms that maycontribute ... models of autoimmu-nity [1,2]. Recently convincing proof of this hypothesis hasbeen provided by the association of the missense single nucle-otide polymorphism (SNP; rs2476601) in the protein tyrosinephosphatase ... association, although they couldnot completely rule out the possibility that the putative IDDM8 locus exists elsewhere in this chromosomal region [20]. Other genes in the IDDM8 region include the KIAA1838...
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Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
... (GSEA) of the microarray data suggested constitutive upregulation of components of the transforming growth factor(TGF)-β pathway in RA SFBs, with 2 hits in the top 30 regulatedpathways. The growth ... recruits the TGF-β-signal-transducingsmads to the membrane in the close vicinity of the receptor[19] (Figure 1). This interesting finding provides detailed anal-ysis of individual components of the ... compo-nents of the pannus and contribute to joint destruction bysecretion of pro-inflammatory cytokines and tissue-degradingenzymes [3].Recently, microarray techniques employing hybridization of biological...
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Báo cáo y học: "Skewed distribution of proinflammatory CD4+CD28null T cells in rheumatoid arthritis" docx
... while the other dominant subset was clearlyrestricted (Figure 4c). Two patients did not display any of these distinct patterns of TCR-Vβ distribution. In all 13 patients, the distribution of TCR-Vβ ... T cells in manifestations elsewhere than in the joints of patients withHCMV-seropositive rheumatoid arthritis.Introduction T cells are likely to play an important role in the pathogenesis of ... pathogenesis of rheumatoid arthritis (RA) (reviewed in [1]). In the synovialjoint, infiltrating T cells are predominantly of the CD4+ pheno-type and are often found in the proximity of B cells and...
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Báo cáo y học: "Anti-tumour necrosis factor therapy and B cells in rheumatoid arthritis" pptx
... in the inflamed synovia and< /b> that blocking the effects of TNF decreases trafficking into and< /b> retention of B cells in the synovia, thereby increasing theirproportion in the peripheral blood. However, ... Dutcher PO, Hadley JA, Sanz I: Cutting edge:anti-tumor necrosis < /b> factor < /b> therapy < /b> in rheumatoid arthritisinhibits memory B lymphocytes via effects on lymphoid ger-minal centres and < /b> follicular dendritic ... blood. However, both pre- and< /b> post-switch memory B cells can be found in the synovia and< /b> no changes were seen in the post-switch subset followingtreatment with infliximab. In mice, the absence of...
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Báo cáo y học: "Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial" pot
... articleAdiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 ... adiponectin concentrations correlatewith the severity of RA evaluated by the extent of joint destruc-tion, indirectly suggesting that adiponectin may be involved in joint destruction by stimulating ... stimulatory factors such as IL-6 and IL-8 are induced by adiponectin soon after stimulation with this factor, the effectsobserved with adiponectin may be mediated by these proin-flammatory cytokines....
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Báo cáo y học: "Enhanced late-outgrowth circulating endothelial progenitor cell levels in rheumatoid arthritis and correlation with disease activity" doc
... (0.2-2.02)a0.3946a Circulating endothelial cell (CEC) number has been evaluated in 15 healthy controls. 7AAD, 7-aminoactinomycin D; DAS-28, 28-joint disease activity score; EPC, endothelial progenitor cell; Lin-, ... endothelial progenitor cell (EPC) levels in rheumatoid arthritis (RA) with disease activity. Correlation between EPC counts and disease activity (a) and association of lower EPC levels in different groups ... discrepancy with regardTable 2: Absolute number of stem cells and circulating endothelial progenitor cells in peripheral blood (cells per 106 lineage-negative mononuclear cells)Cells per 106 Lin-mononuclear...
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Báo cáo y học: " Profibrotic potential of Prominin-1+ epithelial progenitor cells in pulmonary fibrosis" docx
... in vitro by cytokines and growth factors. Pulmonary fibrosis was induced in C57Bl/6 mice byintratracheal instillation of bleomycin. Prominin-1+progenitors were administered intratracheally ... administration of prominin-1+progenitors only 2 hours after bleomycininstillation prevents pulmonary fibrosis development.Instead, transplantation of prominin-1+progenitors dur-ing ongoing inflammation ... of prominin-1+ cells 2 hours afte r bleomycin instillationprotects from pulmonary fibrosis, and some of progenitors differentiate into alveolar ty pe II epithelial cells. In contrast, prominin-1+cells...
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Báo cáo y học: " Increased levels of (class switched) memory B cells in peripheral blood of current smokers" docx
... individu- Memory < /b> B cells in peripheral bloodFigure 4 Memory < /b> B cells in peripheral blood. A) Percentages of < /b> memory < /b> B cells and class switched memory < /b> B cells (D) in periph-eral blood of < /b> current ... regressionanalysis).Flow cytometry plots of < /b> B cells and memory < /b> B cells in peripheral bloodFigure 1Flow cytometry plots of < /b> B cells and memory < /b> B cells in peripheral blood. A representative example of < /b> the ... maylead to increased < /b> numbers of < /b> memory < /b> B cells and plasma cells, and a continued presence of < /b> memory < /b> B cells, asshown in the current smokers in our study.Because this increase in memory < /b> B cells...
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Báo cáo y học: "Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis" docx
... regarding PTPN22 +1858C/T polymorphism and PsA have produced conflictingresults. In a study by Hinks et al., no association wasfound between PsA and PTPN22 +185 8C/T in a patientpopulation from the ... regression analysis (P = 0.017). There was noassociation between dactylitis and deformed joints and, no other significant associations between the ca rriage of the risk allele, T, and other examined ... PsA wereexamined clinically, by standard laboratory tests and their DNA was genotyped for the SNP rs2476601 (PTPN22 +1858 C/T) . Allelic frequencies were determined and compared with 725 controls.Results:...
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Báo cáo y học: " Statistical distribution of blood serotonin as a predictor of early autistic brain abnormalities" ppt
... of 5-hydroxytryptamine (5-HT, serotonin) in blood platelets (platelet hyperserotonemia). The early developmental alteration of the autistic brain and the autistic platelet hyperserotonemia may ... CentralPage 1 of 16(page number not for citation purposes)Theoretical Biology and Medical ModellingOpen AccessResearch Statistical distribution of blood serotonin as a predictor of early autistic ... skirmantas.janusonis@yale.edu* Corresponding author AbstractBackground: A wide range of abnormalities has been reported in autistic brains, but theseabnormalities may be the result of an earlier...
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Báo cáo y học: "Taxonomic distribution of large DNA viruses in the sea" pptx
... to those exhibited by other groups of eukaryotic large DNA viruses, including most of the previ-ously characterized phycodnaviruses. The amoeba infectingmimivirus has the largest known viral ... fragments in this study. Weparsed the GOS PolB fragments to find intein insertions by the TIGRFAM profiles TIGR01445 (intein amino terminus)and TIGR01443 (intein carboxyl terminus) [65], but none of these ... of these fragments had a detectable intein domain. In this study,we did not include the protein priming subfamily of the Bfamily DNA polymerase [28], which is represented by the Pfam profile...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinChuong 2 nhận dạng rui roTăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM