Báo cáo y học: "Skewed distribution of proinflammatory CD4+CD28null T cells in rheumatoid arthritis" docx

... medical emergency contacts outside hospitals in Norway - a prospective population based study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2010 18:9. Submit your next manuscript ... score was in the analyses cate- gorised as NACA 0-1 , indicating a patient either with no symptoms/injuries or in no need of medical treat- ment,...

Ngày tải lên: 25/10/2012, 09:56

... haematoxylin and eosin stained sections. Immunohistochemistry for HIF-1 α and HIF-2 α expression The HIF- 1α and HIF- 2α proteins were detected using ESEE 122 (IgG 1 monoclonal antibody [mAb]; ... significant. Results HIF- α expression in synovial lining cells HIF- 1α and HIF- 2α expression was both cytoplasmic and nuclear in arthritic synovial tissues (Fig. 1a,b). The...

Ngày tải lên: 09/08/2014, 01:21

... of lipocalin-type prostaglandin D synthase (L-PGDS) protein in healthy and osteoarthritis (OA) cartilageExpression of lipocalin-type prostaglandin D synthase (L-PGDS) protein in healthy and osteoarthritis ... 7 Effect of prostaglandin D 2 (PGD 2 ) on interleukin-1-beta (IL-1β)-induced upregulation of lipocalin-type prostaglandin D synthase (L-PGDS) expressionE...

Ngày tải lên: 09/08/2014, 01:22

... than the threshold calcium concentration for PAD activity (approximately Commentary Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis Erik R Vossenaar and Walther ... in the inflamed synovium, especially in the synovial fluid. Because granulocytes have a lifespan of only about 3 days, they will die in large numbers at the site of...

Ngày tải lên: 09/08/2014, 01:23

... box- binding protein (TBP) amongst others. The aim of this study was to fine map the IDDM8 region on chromosome 6q27, focusing on the genes in the region, to identify polymorphisms that may contribute ... models of autoimmu- nity [1,2]. Recently convincing proof of this hypothesis has been provided by the association of the missense single nucle- otide polymorphis...

Ngày tải lên: 09/08/2014, 08:22

... (GSEA) of the microarray data suggested constitutive upregulation of components of the transforming growth factor (TGF)-β pathway in RA SFBs, with 2 hits in the top 30 regulated pathways. The growth ... recruits the TGF-β-signal-transducing smads to the membrane in the close vicinity of the receptor [19] (Figure 1). This interesting finding provides det...

Ngày tải lên: 09/08/2014, 10:20

... while the other dominant subset was clearly restricted (Figure 4c). Two patients did not display any of these distinct patterns of TCR-Vβ distribution. In all 13 patients, the distribution of TCR-Vβ ... T cells in manifestations elsewhere than in the joints of patients with HCMV-seropositive rheumatoid arthritis. Introduction T cells are likely to play an important...

Ngày tải lên: 09/08/2014, 10:21

... in the inflamed synovia and < /b> that blocking the effects of TNF decreases trafficking into and < /b> retention of B cells in the synovia, thereby increasing their proportion in the peripheral blood. However, ... Dutcher PO, Hadley JA, Sanz I: Cutting edge: anti-tumor necrosis < /b> factor < /b> therapy < /b> in rheumatoid arthritis inhibits memory B lymphocytes via eff...

Ngày tải lên: 09/08/2014, 14:22

... article Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 ... adiponectin concentrations correlate with the severity of RA evaluated by the extent of joint destruc- tion, indirectly suggesting that adiponectin may...

Ngày tải lên: 09/08/2014, 14:22

... (0.2-2.02) a 0.3946 a Circulating endothelial cell (CEC) number has been evaluated in 15 healthy controls. 7AAD, 7-aminoactinomycin D; DAS-28, 28-joint disease activity score; EPC, endothelial progenitor cell; Lin - , ... endothelial progenitor cell (EPC) levels in rheumatoid arthritis (RA) with disease activity. Correlation between EPC counts and disea...

Ngày tải lên: 12/08/2014, 11:23

... in vitro by cytokines and growth factors. Pulmonary fibrosis was induced in C57Bl/6 mice by intratracheal instillation of bleomycin. Prominin-1 + progenitors were administered intratracheally ... administration of prominin-1 + progenitors only 2 hours after bleomycin instillation prevents pulmonary fibrosis development. Instead, transplantation of prominin-1 + progenitors dur- i...

Ngày tải lên: 12/08/2014, 14:20

... individu- Memory < /b> B cells in peripheral bloodFigure 4 Memory < /b> B cells in peripheral blood. A) Percentages of < /b> memory < /b> B cells and class switched memory < /b> B cells (D) in periph- eral blood of < /b> current ... regression analysis). Flow cytometry plots of < /b> B cells and memory < /b> B cells in peripheral bloodFigur...

Ngày tải lên: 12/08/2014, 14:20

... regarding PTPN22 +1858C/ T polymorphism and PsA have produced conflicting results. In a study by Hinks et al., no association was found between PsA and PTPN22 +185 8C/T in a patient population from the ... regression analysis (P = 0.017). There was no association between dactylitis and deformed joints and, no other significant associations between the ca rriage of th...

Ngày tải lên: 12/08/2014, 15:22

... of 5-hydroxytryptamine (5-HT, serotonin) in blood platelets (platelet hyperserotonemia). The early developmental alteration of the autistic brain and the autistic platelet hyperserotonemia may ... Central Page 1 of 16 (page number not for citation purposes) Theoretical Biology and Medical Modelling Open Access Research Statistical distribution of blood serotonin a...

Ngày tải lên: 13/08/2014, 23:20

... to those exhibited by other groups of eukaryotic large DNA viruses, including most of the previ- ously characterized phycodnaviruses. The amoeba infecting mimivirus has the largest known viral ... fragments in this study. We parsed the GOS PolB fragments to find intein insertions by the TIGRFAM profiles TIGR01445 (intein amino terminus) and TIGR01443 (intein carboxyl term...

Ngày tải lên: 14/08/2014, 20:22