Báo cáo khoa học: " The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications" pptx

... signal-regulated kinases: association with epidermal growth factor receptor/ transforming growth factor alpha expression in head and neck squamous carci- noma and inhibition by anti -epidermal growth factor ... Access Review The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications Michel...

Ngày tải lên: 09/08/2014, 10:20

... studies. Background The epidermal growth factor receptor (EGFR) pathway plays key roles in the development and maintenance of many tissue and organ systems [1]. Recent reports have suggested that the EGFR ... background, maintained through a cross-out- cross mating scheme, harboring the Egfr wa2 and Wnt3a vt alleles in cis segregates known and unknown mutations...

Ngày tải lên: 10/08/2014, 09:20

... Importantly, chicken HSF1 and mouse HSF3 are involved in protecting cells from heat shock and in maintaining protein homeostasis without induc- ing the expression of the classical heat shock genes. ... genes. Interestingly, the amino-terminal region of chicken HSF1 containing an alanine-rich sequence and the DNA-binding domain is sufficient to cause the func- tional differe...

Ngày tải lên: 18/02/2014, 04:20

... with IGF-1 signaling also in C2 myoblasts overexpressing the insulin-like growth factor 1 binding protein 5 and therefore not responding to endogenously produced insulin-like growth factor 1. Although ... insulin-like growth factor 1; IGFBP5, insulin-like growth factor 1-binding protein; IRS-1, insulin receptor substrate 1; kiAKT, kinase-inactive form of AKT; LY, LY294...

Ngày tải lên: 19/02/2014, 06:20

... [31]. The role of Ets factors in inflammation and in the regulation of cytokine-responsive genes has not been studied in detail. However, several genes, including urokinase-type plasminogen activator, ... Manning C, Akbarali Y et al. (2003) Responses to the proinflammatory cyto- kines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium...

Ngày tải lên: 19/02/2014, 17:20

... function to either activate or inhibit protein synthesis and cell growth [2]. The most well defined signaling mechanism regulating mTOR activity in skeletal muscle is the insulin like growth factor- 1 ... protein binding. Having established the importance of the S939 site in TSC2 for the phosphorylation-dependent 14-3-3 interaction, we next aimed to determine whether this...

Ngày tải lên: 15/03/2014, 11:20

... important for regulating in ammatory events in macrophages, including the expression of proinflammatory cytokines and chemokines [e.g. tumour necrosis factor a (TNFa), interleukin (IL)-1b, IL-6, ... to the liver in CMR in the postprandial phase. In this study, we investigated the effects of CMR on NF-jB activation in macrophages and determined whether these are modulat...

Ngày tải lên: 23/03/2014, 04:20

... evelopment when swapped into the HNF1a protein. These include the dimerization domain, the 26 a a segment and the homeo- domain. It is noteworthy that the dimerization domain of the HNF1b protein interferes ... domain of the HNF1b protein failed to increase the transactivation potential of the truncated HNF1a protein. However, the replacement of either the POU S and...

Ngày tải lên: 23/03/2014, 13:20

... controlling initial differences in thermotolerance (e.g. caused by differences in HaHSFA9 overexpression). In addition, within each comparison, we used sibling lines differing only in the inheritance ... obtained after SalI and XbaI diges- tion of plasmid pSK-ds10EC1-HA:HaDREB2, and it was inserted in the corresponding restriction sites in the polylinker of the binary...

Ngày tải lên: 12/08/2014, 03:20

... Delafontaine P: Tumor necrosis factor- alpha regulates insulin-like growth factor- 1 and insulin-like growth factor binding protein-3 expression in vascular smooth muscle. Circulation 2002, 105: 1220-1225. 37. ... tran- scription factors, such as nuclear factor- κB, both in cardiac myocytes and the endothelium; in turn, this initiates transcrip- tion of genes including th...

Ngày tải lên: 12/08/2014, 19:22