Báo cáo y học: "Tumour necrosis factor blockade and the risk of osteoporosis: back to the future " ppt

... efficacy. Application of such auto- mated radiogrammetry to the existing clinical trial data (such as these hand X-rays) offers an opportunity to examine the effects of TNF blockade on bone loss and ... technique of metacarpal morphometry employed in these three old studies is identical with that measured by modern day automated radiogrammetry. Moreoever, automated radiogram...

Ngày tải lên: 09/08/2014, 10:20

... healthy donors. BM revised the article critically. JLD was involved in the design of the study and reviewed the article critically. AC was involved in the conception and design of this study, in the ... E-selectin and intercellular adhesion molecule, necessary for the flow of leucocytes into the sub- endothelial tissue [6]. It also promotes production of other pr...

Ngày tải lên: 09/08/2014, 10:20

... improved greatly the quality of life of the patients, and was shown to significantly retard the structural damage that is typical of this chronic inflammatory disorder. In the field of spondyloarthropathies ... necrosis factor- α (TNF-α) proved highly efficacious, with an acceptable safety profile in the chronic treatment of rheumatoid arthritis. Not only did the...

Ngày tải lên: 09/08/2014, 06:23

... closely the activation of MAPK by TNF in vivo, we histologically assessed joints of hTNFtg mice and wild-type mice for phosphorylated forms of p38MAPKα, ERK and JNK. Synovial inflammatory tissue of ... effects of systemic blockade of TNF, IL-1 and receptor activator of nuclear factor- κB (RANK) ligand on the activation of MAPKs were assessed. In vivo, overexpress...

Ngày tải lên: 09/08/2014, 07:20

... necrosis factor- α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor- κB and activator protein-1 in the regulation of expression of cytochrome ... Bjorkhem I, Seckl J, Lathe R: Cyp7b, a novel brain cyto- chrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy...

Ngày tải lên: 09/08/2014, 07:20

... promotes further expression of cytokines and chemokines by synovial cells and chondro- cytes, thereby sustaining a renewal of local inflammatory mediators (reviewed in [9,10]). The presence of TNF-α ... loss and changes in cell morphology. The MAPK/ERK pathway is thereby at least partially involved in regulating the aggrecan and type II collagen genes and in remodeling...

Ngày tải lên: 09/08/2014, 06:22

... only transitory, because a portion of YopD is also localized to the host cell cytosol [10]. In addition, we and others observed that a yopD null mutant is constitutively induced for synthesis of ... spin system assignments of YopD 278)300 were obtained using COSY and TOCSY spectra and a NOESY spectrum was used to identify sequential backbone connectivities. A comparison of...

Ngày tải lên: 31/03/2014, 21:21

... or TBP, and taken as the loading controls, and also to assess the purity of nuclear and cytosolic preparations. Bands were analysed densitometrically as described below. Immunofluoresence microscopy HepG2 ... agarose gel, photographed with the Alpha Innotech gel documentation system and the intensity of each band was analysed densitometrically and plotted after normaliz...

Ngày tải lên: 16/03/2014, 02:20

... (ligand) superfamily; TRAF, tumor necrosis factor receptor-associated factor; TTRAP, tumor necrosis factor receptor-associated factor and tumor necrosis factor receptor-associated protein. ... tumor necrosis factor receptor superfamily; TNFRSF12, WSL-1-like protein; TNFRSF22, tumor necrosis factor receptor family member SOBa mRNA; TNFSF, tumor necrosis factor...

Ngày tải lên: 09/08/2014, 14:22

... was involved in the conception and design of the study, analysis and interpretation of the data, and did most of the drafting of the manuscript. All authors read and approved the final manuscript. Acknowledgements We ... proteoglycan degradation in carti- lage tissues can be mediated by both the production of NO and the involvement of matrix-degrading enz...

Ngày tải lên: 09/08/2014, 14:22