Báo cáo y học: "Tumour necrosis factor blockade and the risk of osteoporosis: back to the future " ppt
Báo cáo y học: "Tumour necrosis factor blockade and the risk of osteoporosis: back to the future " ppt
... efficacy. Application of such auto-mated radiogrammetry to the existing clinical trial data (suchas these hand X-rays) offers an opportunity to examine the effects of TNF blockade on bone loss and ... technique of metacarpal morphometry employed in these three old studiesis identical with that measured by modern day automatedradiogrammetry. Moreoever, automated radiogrammetry usinghand X-rays ... be an example of how older metho-dology can still provide insights into modern aspects of patho-genesis and treatment – hence the title back to the future .Competing interests The author declares...
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Báo cáo y học: "Tumor necrosis factor alpha and adalimumab differentially regulate CD36 expression in human monocytes" ppt
... healthy donors. BM revised the article critically.JLD was involved in the design of the study and reviewed the article critically. AC was involved in the conception and design of this study, in the ... E-selectin and intercellular adhesionmolecule, necessary for the flow of leucocytes into the sub-endothelial tissue [6]. It also promotes production of otherproinflammatory cytokines and chemokines, ... Kolch W, Scheurich P: Ligands working as receptors:reverse signaling by members of the TNF superfamilyenhance the plasticity of the immune system. Cytokine Growth Factor Rev 2004, 15:353-366.46....
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Báo cáo y học: "α Tumor necrosis factor-α blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification" pps
... improved greatly the quality of life of the patients, and was shown to significantly retard the structural damagethat is typical of this chronic inflammatory disorder. In the field of spondyloarthropathies ... necrosis factor- α(TNF-α) proved highly efficacious, with an acceptable safetyprofile in the chronic treatment of rheumatoid arthritis. Notonly did the therapy turn out to alleviate signs and symptoms,but ... http://arthritis-research.com/content/7/3/R439123decrease in the hypervascularity typical of SpA and areduction of the synovial lining hyperplasia, indicating thatinfliximab also modulates the structural synovial charac-teristics of the disease....
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Báo cáo y học: "Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo" doc
... closely the activation of MAPK by TNF in vivo, wehistologically assessed joints of hTNFtg mice and wild-typemice for phosphorylated forms of p38MAPKα, ERK and JNK.Synovial inflammatory tissue of ... effects of systemic blockade of TNF, IL-1 and receptor activator of nuclear factor- κB (RANK) ligand on the activation of MAPKs were assessed.In vivo, overexpression of TNF induced activation of ... in both synovial macrophages and fibroblasts. T and B lymphocytes did not exhibit major activation of any of the three MAPKs. Systemic blockade of TNF reducedactivation of p38MAPKα and ERK,...
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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... necrosis factor- α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor- κB and activator protein-1 in the regulation of expression of cytochrome ... Bjorkhem I, Seckl J, Lathe R: Cyp7b, a novel brain cyto-chrome P450, catalyzes the synthesis of neurosteroids7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxypregnenolone. Proc Natl Acad ... [6,7]. The conversion of DHEA into 7α-OH-DHEA is catalyzed bycytochrome p450 enzyme 7b (Cyp7b) [8]. Because of the reported immunostimulating effects of 7α-OH-DHEA, we pre-viously investigated the...
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Báo cáo y học: "Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte" pptx
... promotes further expression of cytokines and chemokines by synovial cells and chondro-cytes, thereby sustaining a renewal of local inflammatorymediators (reviewed in [9,10]). The presence of TNF-α ... loss and changes in cell morphology. The MAPK/ERK pathway is thereby at least partially involved inregulating the aggrecan and type II collagen genes and inremodeling of the cytoskeleton in ... regulate the breakdown of the established matrix and the synthesis of new extracellular matrix molecules. In the present study, weinvestigated the effects of tumor necrosis factor alpha (TNF-α)and...
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Báo cáo Y học: Conformational analysis by CD and NMR spectroscopy of a peptide encompassing the amphipathic domain of YopD from Yersinia potx
... onlytransitory, because a portion of YopD is also localized to the host cell cytosol [10]. In addition, we and others observedthat a yopD null mutant is constitutively induced forsynthesis of ... spin system assignments of YopD278)300were obtained using COSY and TOCSYspectra and a NOESY spectrum was used to identifysequential backbone connectivities. A comparison of the Ha and Cachemical ... pair-wise rmsd of 2 A˚or morefor the backbone heavy atoms, 150 structures were calcu-lated using the SA and SA refinement protocols. To describe the quality of the solution structure of YopD278)300,...
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Báo cáo khoa học: Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells pptx
... orTBP, and taken as the loading controls, and also to assess the purity of nuclear and cytosolic preparations. Bandswere analysed densitometrically as described below.Immunofluoresence microscopyHepG2 ... agarose gel, photographedwith the Alpha Innotech gel documentation system and the intensity of each band was analysed densitometrically and plotted after normalization to that of the input DNA. ... shown the regulation of gluconeogenic enzymes by another forkhead transcrip-tion factor, Foxo1 [23,24], others have reported that the overexpression of Foxo1 carries the message to G6Pase only and...
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Báo cáo y học: "Tumor necrosis factor α-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis" pptx
... (ligand) superfamily; TRAF, tumor necrosis factor receptor-associated factor; TTRAP, tumor necrosis factor receptor-associated factor and tumor necrosis factor receptor-associated protein. ... tumor necrosis factor receptor superfamily; TNFRSF12, WSL-1-like protein; TNFRSF22, tumor necrosis factor receptor family member SOBa mRNA; TNFSF, tumor necrosis factor (ligand) superfamily; ... accordance with the protocol provided by the manufacturer. Analysis was performed by gene expressionsoftware.Analysis of TIARP and tumor necrosis factor- alpha gene expressionSpleens and lymph nodes...
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Báo cáo y học: "Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro" pptx
... was involved in the conception and design of the study, analysis and interpretation of the data, and did most of the drafting of the manuscript. All authors read and approved the final manuscript.AcknowledgementsWe ... proteoglycan degradation in carti-lage tissues can be mediated by both the production of NO and the involvement of matrix-degrading enzymes. We there-fore studied the influence of the NO-synthetase ... hard to differentiate, probably due to the fact that immunohisto-chemistry is not useful for the differentiation of slightly variableexpression levels. We therefore mainly focus on the effect of inhibitors...
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