Báo cáo y học: "Remission by composite scores in rheumatoid arthritis: are ankles and feet important" pptx

... assessment in RA. In this study, we showed that the assessment of joint activity in the feet, beyond assessment of joint activity by the 28-joint count, does not convey significant added value in the ... that while providing useful and important clinical information, the inclusion of ankles and feet only rarely influences the definition of overall disease activity status, e...

Ngày tải lên: 09/08/2014, 10:20

... who are ‘responders’ by signs and symptoms, including physical function and radiographic outcomes [48]. These individuals have documented RA and cannot be characterized by differ- ences in demographics ... Sandberg G, Crayton H: Demyelination occurring during anti TNF therapy for inflammatory arthritides. Arthritis Rheum 2001, 44:2862- 2869. 65. Robinson WH, Genovese MC, Morelan...

Ngày tải lên: 09/08/2014, 01:22

... of inflammatory cells, including monocytes and lymphocytes [1]. It has been proposed that the first cells to infiltrate syn- ovial tissue are T lymphocytes, suggesting that they have an important role in ... was stopped by immersion in water. Sections were counter- stained in Mayer's hemalum, dehydrated in alcohol, cleared in xylene, and mounted in DPX (BDH, Poole, UK...

Ngày tải lên: 09/08/2014, 01:24

... followed by detection of the gelatinolytic activ- ity and quantity in the conditioned media by gelatin zymogra- phy [22,23]. In brief, the conditioned medium was resolved by SDS-PAGE under non-reducing ... 3 Gelatin zymography of culture medium conditioned by fibroblast-like synoviocytes (FLS) and monocytes/macrophagesGelatin zymography of culture medium conditioned by fibro...

Ngày tải lên: 09/08/2014, 07:20

... primer). Results and discussion In marked contrast to previous findings, no polymorphic alleles (neither thymine at position 40 nor cytosine at position 1,400) were detected in any of the individuals ... frequencies of SNPs linked to RA have been already reported [8]. Analysis of RA-associated SNPs in solute carrier family 22 members 4 and 5 (SLC22A4 and SLC22A5) [9] and in pr...

Ngày tải lên: 09/08/2014, 07:20

... H, Hyldstrup L; the TIRA group: Bone loss in unclassified polyarthritis and early rheumatoid arthritis is better detected by digital X-ray radiogrammetry than dual energy X-ray absorptiometry: ... with early rheumatoid arthritis. Lancet 1994, 344:23-27. 4. Deodhar AA, Brabyn J, Pande I, Scott DL, Woolf AD: Hand bone densitometry in rheumatoid arthritis, a five year longitudinal...

Ngày tải lên: 09/08/2014, 10:22

... CT and MRI in a study of nine RA wrist joints by Perry and colleagues [12] may partly be explained by more advanced joint destruc- tions in their cohort. In comparison with our previous study ... of value for detecting and monitoring bone erosions in RA. The sensitivity to change is not yet established, however, and CT is disfavored by using ionising radiation and by...

Ngày tải lên: 09/08/2014, 10:23

... N-terminal and C-terminal ends, the telopeptides. In the extracellular matrix, the collagen molecules are linked to one another by cross-linking molecules such as pyridinoline; this cross- linking ... Pre-analytical and biological variability in circu- lating interleukin 6 in healthy subjects and patients with rheumatoid arthritis. Biomarkers 2008, 13:59-78. 54. Weyand CM, K...

Ngày tải lên: 09/08/2014, 10:23

... activity to HDAC activity may sensitize cells to inflammatory gene transcription via chromatin remodeling, may increase the DNA binding and activity of transcription factors, and may increase ... compound identified by this strategy is tubacin, a specific inhibitor of HDAC6 [21]. Sirtuins, as well as other nicotinamide adenosine dinucleotide-dependent enzymes, are inhibited by nicot...

Ngày tải lên: 09/08/2014, 11:20

... online supplementary materials, and their rat orthologs were obtained by querying NCBI Homolo- Gene database [34]. The Gene Ontology (GO) analysis was carried out by using GoMiner, developed by ... immune and inflammatory systems are intimately linked. Studies on affected joints focusing on cartilage, bone, and synovial tissues have yielded important insights into the mechanisms...

Ngày tải lên: 09/08/2014, 07:20