Báo cáo y học: "Identification of an altered peptide ligand based on the endogenously presented, rheumatoid arthritis-associated, human cartilage glycoprotein-39(263–275) epitope: an MHC anchor variant peptide for immune modulation" pot

... modification at the key MHC anchor position. The latter quality may add to improved safety of APL therapy. Ideally, the properties of an APL for immunotherapy of RA would blend: affinity for MHC class ... substitutions may function as partial TCR agonists on the one hand and prevent unwanted immune reactivity on the other [32,33]. This approach may thus provi...

Ngày tải lên: 09/08/2014, 10:20

... Yuliana, Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; S Oka* and M Honda, International Medical Centre of Japan, Tokyo, Japan; JY Choi* and SH Han, Division ... Insti- tute of Allergy and Infectious Diseases (NIAID), grant no. U01-AI069907, and the Ministry of Foreign Affairs of the government of The Netherlands. The National Centre in...

Ngày tải lên: 10/08/2014, 05:20

... of inhibition can be explained by the variety of different anti-Sm antibody sub- populations and by the variety of corresponding epitopes. Recently, two polyclonal antibodies (SYM10, SYM11) were ... mapping of the carboxyl-terminal extensions of SmD1 and SmD3 To evaluate the effect of arginine dimethylation on the anti- genicity of SmD1 and SmD3 and to localize rele...

Ngày tải lên: 09/08/2014, 06:22

... bleeding lesion. GI evaluation can be endoscopic and radiographic. Asymptomatic colonic and gastric carcinoma may present with IDA and exclusion of these conditions is of prime concern. The upper ... [3-6, 11]. Iron deficiency anemia is considered as an alarm sign for the presence of possible GI malignancies, and inadequate evalua- tion of patients with IDA may delay the...

Ngày tải lên: 25/10/2012, 11:18

... recombination. Yeast colony PCR was done for 22 randomly picked colonies to assess the size of cDNA insert. For each colony picked, half was streaked on SD/-Trp plate and the other half inoculated ... are then cloned into the yeast cell and expressed on the cell membrane. If the prey protein interacts with the bait protein, this would bind the NubG and Cub domains...

Ngày tải lên: 02/11/2012, 11:08

... [38]. The same abnormality was also observed when the phylogenetic analysis of S. mansoni nuclear receptors was performed [39]. The proposed explanation for this observation is that the human parasites ... strong inhibitory effect of S-hexyl glutathione on the enzyme activity. The preference of SmGSTO for more hydrophobic alkyl-bound S-hexyl glutathione rather than g...

Ngày tải lên: 21/02/2014, 01:21

... (re)differentiation potential of distinct subpopulations are necessary to improve further the functional quality of the cell populations used for transplantation. The methods of FACS analysis and cell ... patients and analyzed the kinet- ics of cultivation and the potential for differentiation. The data analysis after sorting is exemplarily shown for one patient in F...

Ngày tải lên: 09/08/2014, 01:23

... analysis and the clinical associa- tions. AS participated in the analysis and interpretation of data and in the revision of the manuscript. RR participated in the design of the study and in the revision ... screening of the library and participated in the design of the study and in the analysis of data. MS carried out the experiments on endothelial cell l...

Ngày tải lên: 09/08/2014, 06:23

... anti-kinectin antibody with different manifesta- tions or disease 'subtypes' of BD is another important project. Anti-kinectin is clearly only one of the antigen-antibody sys- tems identified ... 3'-untranslated region. (b) Autoradiography of in vitro transcription and translation products of the candidate clones BD44 and BD42 labeled by [ 35 S]-methionine and anal...

Ngày tải lên: 09/08/2014, 07:20

... is demonstrated by the uniform migration of deiminated enolase at a pI of 5 and by the replacement of arginine by citrulline in all the peptides listed in Table 1. In our study, 15% of the control ... mainly confined to the subsynovium. (b) No staining was visible on the control. (c) Staining produced by the anti-α-enolase antibody on an adjacent section was much...

Ngày tải lên: 09/08/2014, 07:20