Báo cáo y học: "Mesangial cells of lupus-prone mice are sensitive to chemokine production" pps

... the significantly elevated levels of both chemokines produced by NZB/W MCs are more likely due to a significantly greater activation of the Toll-like receptor 4-myeloid differentiation factor 88-associated ... that are more responsive to LPS. On the other hand, MCs also express Toll-like receptor-2 [41] and Toll-like receptor-3 [21] that caused secretion of proinflamma- tory cyt...

Ngày tải lên: 09/08/2014, 10:20

... play a key role in the pathogenesis of inflammatory arthritis. In addition to autoantibody production, B cells efficiently present antigen to T cells, produce soluble factors, including cyto- kines ... induction and maintenance of the proinflammatory cytokine cascade. Role played by B cells as antigen-presenting cells in rheumatoid arthritis B cells actively participate in an...

Ngày tải lên: 09/08/2014, 10:20

... antigen to local naïve T cells, disappearing after several days due to apoptosis and active killing by cytotoxic T cells [21]. Depending on the nature of the inflammatory signal received by immature ... (APC). DC are also essential accessory cells in the generation of primary antibody responses, and are powerful enhancers of natural killer T cells and of natural killer...

Ngày tải lên: 09/08/2014, 10:20

... IL-10, and IL-13 are generally classified as inhibitory or modulatory cytokines because they are able to inhibit many of the cartilage catabolic processes induced by proinflammatory cytokines [105]. ... has been attributed to the release of inflammatory mediators and degradative enzymes released by polymorphonuclear leuko- cytes and other inflammatory cells in the synovial fluid...

Ngày tải lên: 09/08/2014, 10:21

... chemokine- mediated recruitment of inflammatory cells, (b) cytokine-mediated activation of newly immigrated inflammatory cells, (c) cell contact-mediated activation of neighboring inflammatory ... in monocytes and inhibits the production of pro- inflammatory cytokines, GM-CSF, and Fc-γ receptors by synovial Mφ. Consistently with cytokine and chemokine downregulation, IL-10 clearl...

Ngày tải lên: 09/08/2014, 10:22

Ngày tải lên: 09/08/2014, 10:22

... way to restore sensitivity to rADI in resistant cells. The expression of AS at levels of mRNA and protein was determined to understand the effect of RNA interference. Cell viability, cell cycle, ... untransduced MCF-7 cells after 1 to 4 days treat- ment with rADI was in the range of 100% to 73% com- pared to cells without rADI treatment. Similarly, the cell viability...

Ngày tải lên: 10/08/2014, 05:21

... concerned as to why C341V exhibits an increased DG à compared with the wild-type enzyme. As the properties of Val, such as size and hydrophobicity, are similar to those of Cys and the affinity of C341V ... chloromethyl ketone derivative of benzyloxycarbonyl- L -phenylalanine. J. Biol. Chem. 250, 5221–5226. 18. Bernardi, G. (1971) Chromatography of proteins on hydroxyl- apatite....

Ngày tải lên: 08/03/2014, 23:20

... capacity is reduced by half to about 2 kb. Nevertheless, many of the cytokines and other modulatory molecules of interest in rheumatic diseases have cDNAs that are small enough to fit into this space. ... decoy receptor, DcR2 [72]. T lymphocytes also home to sites of inflammation and immune reactivity. Like APCs, they may be genetically modified and used to target multiple sit...

Ngày tải lên: 09/08/2014, 01:22

... Ets-1/Smad3 synergy. Addition of the general PKC inhibitor bisindolylmaleimide I (bis; 10 µM) blocks the ability of Ets-1 to activate the CCN2 promoter. Conversely, addition of bisindolylmaleimide ... GGAA/T, are a large family of transcription factors of which several members are expressed in a tissue- and cell type-restricted fashion [12,13]. Because of this diversity, mu...

Ngày tải lên: 09/08/2014, 07:20