Báo cáo y học: "γ Activating and inhibitory Fcγ receptors in rheumatoid arthritis: from treatment to targeted therapies" potx

... efficacy because they will prevent IgG-containing immune complexes from binding to activating but also inhibitory FcγRs. Drugs that shift the FcγR balance toward the inhibitory FcγRIIb, such as Fc-sialylated ... shift in the balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of mono...

Ngày tải lên: 09/08/2014, 10:20

... step in inflammatory situations. COX-1 and COX-2 are expressed in inflamed bone tissue [17] and COX inhibitors are extensively used in the treatment of rheumatoid arthritis. However, inadequate information ... article Cyclooxygenases and prostaglandin E 2 receptors in growth plate chondrocytes in vitro and in situ – prostaglandin E 2 dependent proliferation of gro...

Ngày tải lên: 09/08/2014, 08:22

... implications are exciting and suggest a new focus for understanding disease pathology and influencing disease progression; moving away from the synovium and towards the bone marrow. Competing interests The ... membrane to become type B synoviocytes - here they mediate formation of erosions via production of proinflammatory cytokines and matrix metalloproteinases [23,25]. (c) Stem...

Ngày tải lên: 09/08/2014, 08:23

... protein 3; FLICE = Fas-associating protein with death domain [FADD]-like interleukin 1β con- verting enzyme [ICE]; FLIP = FLICE inhibitory protein; HD = high-density; HE = hematoxylin and eosin; ... that cyclin-dependent kinase inhibitor p16 INK4a is induced in RA-SF by several growth-inhibited conditions, including irradiation, serum depletion and high cellular density. Surprisingly,...

Ngày tải lên: 09/08/2014, 06:22

... colony-stimulating factor. 281 CFU-M = colony-forming-unit megakaryocyte; COX-2 = cyclooxygenase; ELISA = enzyme-linked immunosorbent assay; GM-CSF = granulocyte–macrophage colony-stimulating factor; ... effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regu- lation by Th2 cytokines. J Immunol 1998, 161:409-414....

Ngày tải lên: 09/08/2014, 06:22

... assay for TNF-α activity was designed using the ability of RA synoviocytes to produce IL-6 and OPG in response to TNF-α [5]. To isolate synoviocytes, RA synovial tissues were finely minced and ... by cytokines in mediating cell–cell interactions in rheumatoid synovium has led to the rational development of treatment with anticytokine agents. Among these proinflammatory c...

Ngày tải lên: 09/08/2014, 06:22

... function in chronic inflammation, to a ‘network concept’ of interacting activities contributing in synergy across distinct tissue events. In particular, cytokine mediated pathology may be distinct in ... milieu of regulatory pathways described for IL-18. High affinity binding by IL-18 binding protein a and c isoforms renders these obvious neutralising agents, and early clinical...

Ngày tải lên: 09/08/2014, 06:22

... frequent [1], indi- cating a considerable influence of other pro-inflammatory cytokines beside TNF in perpetuating inflammation in RA. IL-15 has been identified as a pro-inflammatory cytokine of potential ... sen- sitivity and possibly also differences in binding to intracellular TNF only (mAb1 and mAb11) or to both intracellular and extra- cellular TNF (2C8). It is thus of in...

Ngày tải lên: 09/08/2014, 07:20

... are known to be involved in the induction and maintenance of the proinflammatory cytokine cascade. Role played by B cells as antigen-presenting cells in rheumatoid arthritis B cells actively participate ... arthritis. FcγRIIB is an inhibitory receptor that suppresses B cells, mast cells and macrophages, and transmits its inhibitory signal via its immunoreceptor tyrosine-base...

Ngày tải lên: 09/08/2014, 10:20

... BDCA-4 Toll-like receptors All except TLR7, TLR8 TLR1, TLR2, TLR4, TLR5, TLR8 TLR7, TLR9 Major cytokines produced IL-12 IFN-α Produce proinflammatory and anti-inflammatory cytokines and chemokines in ... proinflammatory cytokines [36-38]. NF-κB- induced cytokines such as TNF, IL-1 and IL-6 activate innate responses in RA, leading to the release of C-reactive protein (CRP) and...

Ngày tải lên: 09/08/2014, 10:20