Báo cáo y học: "Constitutive upregulation of the transformin

Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc

... (GSEA) of the microarray data suggested constitutive upregulation of components of the transforming growth factor (TGF)-β pathway in RA SFBs, with 2 hits in the top 30 regulated pathways. The growth ... recruits the TGF-β-signal-transducing smads to the membrane in the close vicinity of the receptor [19] (Figure 1). This interesting finding provides det...

Ngày tải lên : 09/08/2014, 10:20

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Báo cáo y học: "Skewed distribution of proinflammatory CD4+CD28null T cells in rheumatoid arthritis" docx

... in the joint by secretion of IFN-γ, might even inhibit the synovial inflammation in RA. The limited presence of CD4 + CD28 null T cells in the synovial fluid, despite increased frequencies in ... only scarcely found in the T-cell infiltrates of the rheumatic synovial membrane and has therefore not been con- sidered a key cytokine in the pathogenesis of...

Ngày tải lên : 09/08/2014, 10:21

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Báo cáo Y học: Structural analysis of the lipopolysaccharide from nontypeable Haemophilus inﬂuenzae strain 1003 potx

... amounts of sialylated Hex3 glycoforms were indicated. b Minor amounts of Hex2 and Hex3 glycoforms lacking acetyl groups or containing a second glycyl group were indicated. c Very minor amounts of ... 25. Methylation analysis of dephosphory- lated O S-1 showed signiﬁcantly increasing amounts of terminal Glc and 2-substituted Hep, thereby indicating phosphorylation of these residues...

Ngày tải lên : 31/03/2014, 21:21

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Báo cáo y học: "Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue" doc

... protein levels in RA synovial tissue compared to that from patients with OA and normal subjects. Hypothetically, in RA synovial tissue the dominating Ang-1 induces the Tie2 pathway, whereas in ... pattern of angiopoietin-1 (Ang-1) in synovial tissues. The arrows denote the lining cell layer, the double arrowhead denotes subsynovial macrophages and the single arrow...

Ngày tải lên : 09/08/2014, 03:24

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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt

... Seurin D, Segovia-Quinson B, Hardouin S, Binoux M: Analysis of serum insulin-like growth factor binding proteins using Western blotting: use of the method for titration of the binding proteins ... 265:12210-12216. 42. Bayne ML, Applebaum J, Chicchi GG, Miller RE, Cascieri MA: The role of tyrosines 24, 31, and 60 in the high affinity binding of insulin-like growth fac...

Ngày tải lên : 09/08/2014, 01:23

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Báo cáo y học: "Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes" docx

... 5 Contribution of protein kinase C (PKC) pathway to transforming growth factor-beta-1 (TGF-β1)-induced expression of the Ank geneContribution of protein kinase C (PKC) pathway to transforming growth ... Smad- independent [20] signaling, in many cell types. However, intra- cellular pathways involved in the regulation of the Ank gene are not well documented in ch...

Ngày tải lên : 09/08/2014, 10:22

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Báo cáo y học: "Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial" pot

... [14]. Nevertheless, serum adiponectin concentrations correlate with the severity of RA evaluated by the extent of joint destruction, indirectly suggesting that adiponectin may be involved in joint ... was partly explained by the induction of tol- erance to inflammatory stimuli by adiponectin [18], the pro- or anti-inflammatory effects of adiponectin on the pathogenesis...

Ngày tải lên : 09/08/2014, 14:22

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Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"

... Huang S, Shao G, Liu L. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression. ... types of PRDMs have been identified in humans [15, 18]. Most of them are located near the N-terminal portion of the proteins followed by zinc-fingers, and are involved...

Ngày tải lên : 25/10/2012, 11:15

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Báo cáo y học: " Experimental ablation of the pancreas with high intensity focused ultrasound (HIFU) in a porcine model"

... Biochemistry parameters In the present study, the amylase levels in the serum and urine were increased in the first 3 days and the first 5 days after HIFU ablation, respectively. But no significant ... clearly delineated from the surrounding normal tissues. Infiltration of inflammatory cells and phorocytosis on the boundary were found in group C. Blood and urine...

Ngày tải lên : 25/10/2012, 11:18

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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx

... the catalytic site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the other face each other, thereby bringing together the substrate-binding ... (Arg405, Lys407, Lys413, Lys414, Lys422, Lys428, and Lys430) oriented in the same direction with the heparin-binding domain at the N-terminal end [14]. The other is...

Ngày tải lên : 21/02/2014, 15:20

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