Báo cáo y học: "Hypoxic conditions increase hypoxia-inducible transcription factor 2α and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients" pps
Báo cáo y học: "Hypoxic conditions increase hypoxia-inducible transcription factor 2α and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients" pps
... important role in regulat-ing the synthesis and assembly of matrix by IPFP-derived stem cells as they undergo chondrogenesis and that this has impor-tant implications for the use of the IPFP in cartilage ... 4-hydroxylase and pro-collagen lysyl-hydroxylase [45-47]. Through these actions,HIF1α affects the rate of synthesis of procollagen chains in vivo and in vitro [48]. HIF2α is closely related ... and that this is mediated by a significantly increasedexpression of key genes expressed by chondrocytes, notably the transcription factors SOX5, SOX6 and SOX9. These find-ings show that oxygen...
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Báo cáo y học: "Prevalence of Overactive Bladder, its Under-Diagnosis, and Risk Factors in a Male Urologic Veterans Population"
... Questions on LUTS included urinary frequency (2 questions), urgency (2), nocturia (1), incontinence (2) and emptying (1). The questionnaire also included medical and surgical history, demographic ... Our study found that 95% reported urinary frequency and 85% nocturia. The increase in our study is consistent with Irwin et al.’s epidemiologic study. Although a higher prevalence of OAB is ... urinary symptoms was given to male pa-tients who visited the general urology outpatient clinic at a Veterans Administration hospital in Brooklyn, NY. It included questions on lower urinary...
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Báo cáo y học: "A k2A-positive Klebsiella pneumoniae causes liver and brain abscess in a Saint Kitt’s ma"
... ampicillin and intermediate to ampicillin/sulbactam. It was sensitive to the cephalosporins (cefazolin, cefotaxime, and cefepime), the fluoroquinolones (ciprofloxacin, levofloxacin), the aminoglycosides ... found in a man from Saint Kitts, a Caribbean island. Case Report A 49 year-old Afro-Caribbean man from the is-land of Saint Kitts presented to a Saint Kitts hospital with a two-day history of ... (amikacin, gentamicin, and tobra-mycin), meropenem, pipercillin/tazobactam and trimethoprim/sulfa. At this point, the patient was started on meropenem. The initial CT scan of the brain done...
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Báo cáo Y học: Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line pptx
... ubiquitinylation of TPH protein was involved in the process, presumably byproviding the targeting tag. In search for any connectionbetween protein phosphorylation and TPH turnover, weexamined the ... and 38 min in the presence and absence of okadaic acid,respectively (Fig. 1A, OA), suggesting an involvement of TPH phosphorylation in recognition of the enzyme by the ubiquitinylation system. Based ... WB).Inhibition of TPH degradation in the cell-freeproteasome system by protein kinase inhibitorsWe examined the involvement of TPH phosphorylation in proteasome-driven degradation of the enzyme in vitro.Oursystem...
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Báo cáo Y học: DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells ppt
... phosphorylates the regulatorylight chain of myosin II the phosphorylation sites beingthreonine 18 and serine 1 9 [22]. In this study, the syntheticpeptide, skeletal myosin light chain kinase substrate ... (pro line 277 to leucine 323) containing the calmodulin-binding domain. In the K42A-DK mutant, a lysine residue at position 42 in t he kinase domain (asterisk) is replaced by an a lanine. The D ... in the presence of C2-andC8-ceramide, the totalDAP kinase activities a lso increased 2.1- and 1.8-fold at3 min, showed a maximal increase of 5.0- and 4.8- foldat 10 min, then gradually...
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Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways" doc
... signaling in FLS from two patients with RA. Treating the cells with 20 µM LY294002, a chemical inhibitor of PI3-kinase, abolished the IL-17-induced increase in the production of IL-6 and IL-8 from ... are coincubated with antigen-stimulated T cells from RA patients [17], a likely hypothesis is that induction of IL-15 requires the combined influence of other proin-flammatory cytokines in addition ... sCD40LR120IntroductionIncreasing attention is being given to the role of IL-17, aproinflammatory cytokine produced by activated T cells, in the perpetuation of joint inflammation in rheumatoidarthritis...
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Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx
... from the central nervous system (CNS)frequently occur in patients with systemic lupus erythematosus(SLE). These symptoms are extremely diverse, including a state of dementia. The aim of this ... YuCL: Cerebrospinal fluid interleukin-6, prostaglandin E2 and autoantibodies in patients with neuropsychiatric systemiclupus erythematosus and central nervous system infections.Scand J Rheumatol ... 23:57-63.18. Yeh TS, Wang CR, Jeng GW, Lee GL, Chen MY, Wang GR, Lin KT,Chuang CY, Chen CY: The study of anticardiolipin antibodies and interleukin-6 in cerebrospinal fluid and blood of Chinesepatients...
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Báo cáo y học: "Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1β stimulated fibroblast-like synoviocytes" doc
... immunostaining in both the cytoplasm and the nucleus. This may indicate that signalling pathwaysother than the MAPK and IκB pathways are involved in the stimulation of MMP-1 and MMP-13. In support of this ... subsiding to the basal levels of nonstimu-lated cells by 60 min. The activation of these pathways led to the activation of a number of transcriptional factors that enhance the expression of various ... part of the homeostatic response toinfection and inflammation, thus playing a critical role in limiting the duration and intensity of immune inflammation [52]. In sup-Figure 6Effect of TauCl...
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Báo cáo y học: "Induction of HLA-B27 heavy chain homodimer formation after activation in dendritic cells" ppsx
... multiplebands in the 80 kDa region were visible (Figure 3a), and at 72hours in KG-1.B27.H114D.D11 6Y cells, in which the higher of the bands detected in KG-1.B27 cells was only weakly vis-ible. The ... implying that these novel structures may not bedisplayed to the immune system at all times. Our data suggeststhat the behaviour of HLA-B27 on dendritic cells may beimportant in the study of inflammatory ... as a result of whichFigure 3Induction of HLA-B27 heavy-chain dimers in KG-1 cells and human dendritic cellsInduction of HLA-B27 heavy-chain dimers in KG-1 cells and human dendritic cells. KG-1,...
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Báo cáo y học: " Elevated risks of death for diabetes mellitus and cardiovascular diseases in Italian AIDS cases" pps
... immunode-ficiency, given that these people are at risk of dying from a multitude of other causes. From a statistical viewpoint, the stratified analyses suffered from the small numbers of observed deaths in ... shown).DM and cardiovascular diseases were the underlyingcause of death of 43 PWA (i.e., they cause 1.4% of alldeaths): 14 deaths were caused by DM, 17 by myocardialinfarction, and 12 by chronic ... numbers of DM, myocardial infarction, and chronic ischemic heart diseases as underlying cause of death in PWA with the expected numbers from the sex- and age-matched, general population of Italy. The...
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