Báo cáo y học: "High synovial expression of the inhibitory FcγRIIb in rheumatoid arthritis" ppsx

... biopsies. FcγRIIb staining was observed in the synovial lin- ing and sub-lining layers, perivasculary and inside lymphocyte infiltrates (e). (d) No staining of the RA synovium was observed when the ... perivasculary. Note the dense staining of FcγRIII in the synovial lining layer. The FcγR stainings were rep- resentative of all other RA tissues stained (n = 26). I...

Ngày tải lên: 09/08/2014, 10:20

... producing HBV The change of IAPs expression in the HBV expressing cells was first investigated by the comparison of the gene expression profile in the HepG2.215 and HepG2 cells using gene array ... contribute to the carcinogenesis is still in the investigation. The involvement of these proteins in the NF-kB related signal transduction pathway that result...

Ngày tải lên: 02/11/2012, 11:17

... immunomod- ulatory potential in RA [24]. Recognizing the preliminary nature of the clinical data supporting a disease-modifying effect for statins in RA and the need for in vivo confirmation of our find- ings, ... within the rheumatoid joint induce expression of the principal regulator of the adaptive response to hypoxia, hypoxia-inducible factor (HIF). The HIF...

Ngày tải lên: 09/08/2014, 08:22

... and 5, the importance of maintaining the local level of IL-1Ra became dramatically apparent, as were the advantages of gene transfer as a means of protein delivery. In the face of continual dilution, ... naturally occurring counterpart by possessing an additional amino-terminal methionine residue and lacking glycosylation [26]. In the first part of the present stud...

Ngày tải lên: 09/08/2014, 01:23

... serving as a storehouse of genetic information, the fraction of total RNA that delivers coding information to the protein- synthesizing machinery (i.e. mRNA ) is in trinsically labile and continuously ... in bacteria, the degree of their coupling can control the access of individual transcripts to the RNA decay machinery, thus influencing the rate of mRNA turnover. F...

Ngày tải lên: 10/08/2014, 05:21

... reactivity VEGF expression was invariably cytoplasmic, and usually strong and diffuse in the synovial lining cells of RA and OA. Normal synovium reacted only weakly with VEGF anti- bodies. PD-ECGF expression ... persistently higher than that in OA, irrespective of the extent of HIF-1α staining. Similarly, the extent of PD-ECGF expression in the syn- ovial rheuma...

Ngày tải lên: 09/08/2014, 01:21

... locally in the inflamed synovium, sug- gesting that they might play a role in the disease process (for references see [3]). Because citrullinated proteins (e.g. fibrin) have been detected in the synovium ... cause the release of larger amounts of cytokines upon stimulation or cause cells to be more sensitive towards these cytokines. The cytokines are the motor of the...

Ngày tải lên: 09/08/2014, 01:23

... accumulation of these cells in the inflamed synovia and that blocking the effects of TNF decreases trafficking into and retention of B cells in the synovia, thereby increasing their proportion in the ... have overlapping roles in this setting, although LTα may play a predominant role in promoting the formation of tertiary lymphoid tissue at sites of chronic infla...

Ngày tải lên: 09/08/2014, 14:22

... [14]. Nevertheless, serum adiponectin concentrations correlate with the severity of RA evaluated by the extent of joint destruc- tion, indirectly suggesting that adiponectin may be involved in joint ... one of the major proinflammatory cytokines in RA FLSs. In this study, RA FLSs stimulated with 10 μg/mL adiponectin increased the production of IL-6, IL-8, and PGE 2 . How...

Ngày tải lên: 09/08/2014, 14:22

... chemokines, with a single amino acid separating the first two cysteines. Cys–X–Cys ligand (CXCL)9 and CXCL10 are members of the small cytokine (intercrine/chemokine) CXC subfamily and represent the specific ... were obtained by synovectomy at the Depart- ment of Orthopaedic Surgery, University of Leipzig, Germany. All samples were collected with the approval of the Ethics...

Ngày tải lên: 09/08/2014, 01:23