Báo cáo y học: " Review Cells of the synovium in rheumatoid arthritis" pot

... http://arthritis-research.com/content/9/4/219 Abstract Dendritic cells are the major antigen-presenting and antigen- priming cells of the immune system. We review the antigen- presenting and proinflammatory roles played by dendritic cells in the initiation ... (ELC) [11,16,94]. In contrast, immature DC are also abundant in the synovial lining and sublining layers of...

Ngày tải lên: 09/08/2014, 10:20

... expression of β-catenin in joint tissues of patients with RA, but high expression of the inhibitor of Wnt/β-catenin signaling, DKK-1, in the inflamed synovium, especially in the synoviocytes and synovial ... that the chondrocytes may not only participate in the destruction of the cartilage matrix by responding to the proinflammatory cytokines released from th...

Ngày tải lên: 09/08/2014, 10:21

... reduction in T-helper (Th)1 interferon-γ producing cells, which are known to be involved in the induction and maintenance of the proinflammatory cytokine cascade. Role played by B cells as antigen-presenting cells ... clinical disease activity, thereby enhancing our understanding of the role played by B cells in human disease. Competing interests The authors declare t...

Ngày tải lên: 09/08/2014, 10:20

... critical for the sustained influx of activated monocytes in the synovial membrane, relies on the altered expression of integrin/selectin pairs on the surface of the two cell types (reviewed in [2]). ... the use of a fully humanized anti-IL-15 antibody in clinical trials [56-58]. Interleukin-18 In the RA synovial membrane, this cytokine of the IL-1 family is e...

Ngày tải lên: 09/08/2014, 10:22

Ngày tải lên: 09/08/2014, 10:22

... driving synovial inflammation and joint destruction. Information regarding the proinflammatory role of interleukin-17-producing T cells and the functional state of regulatory T cells both in animal ... reciprocally on T cells to drive production of other cytokines and surface molecules involved in the effector phase of joint inflammation. The population of effector...

Ngày tải lên: 09/08/2014, 10:20

... is induced during growth inhibition in murine cell lines [33]. Recently, Taniguchi et al. [34] showed that cyclin-dependent kinase inhibitor p16 INK4a is induced in RA-SF by several growth-inhibited ... distribution of distinct genes, namely S100A4, NFAT5, Fbx3 and unr, all of which were upregulated in LD cells, by in situ hybridiza- tion. S100A4 mRNA was expressed both in the...

Ngày tải lên: 09/08/2014, 06:22

... [1], indi- cating a considerable influence of other pro-inflammatory cytokines beside TNF in perpetuating inflammation in RA. IL-15 has been identified as a pro-inflammatory cytokine of potential ... for therapy. In this study we investigated the effect of TNF blockade (infliximab) on the synovial expression of IL-15 in RA in relation to different cell types and expressi...

Ngày tải lên: 09/08/2014, 07:20

... chronic inflammatory diseases, such as RA, indicates that these cells may play an important role in chronic inflammation. It is increasingly apparent neutrophils exhibit many of the properties of their ... in chronic inflammation. Many of these factors are pivotal in causing tissue destruction, either directly or indirectly. We are still to determine the importance of the...

Ngày tải lên: 09/08/2014, 10:20

... chronic inflammation, to a ‘network concept’ of interacting activities contributing in synergy across distinct tissue events. In particular, cytokine mediated pathology may be distinct in cartilage ... IL-18 often acts in synergy rather than independently, and for some activities it remains unclear whether direct or indirect effects predominate. A further intriguing activity is the...

Ngày tải lên: 09/08/2014, 06:22