Báo cáo y học: " Major biological obstacles for persistent cell-based regeneration of articular cartilage" pps
Báo cáo y học: " Major biological obstacles for persistent cell-based regeneration of articular cartilage" pps
... members of the TGF-β superfamily reveal asignificant level of chondrocyte hypertrophy, indicated by highlevels of collagen type X expression. Although the use of collagen type X as a marker of chondrocyte ... lesion is contained within the articular cartilage, there is no involvement of the vasculature.Review Major biological obstacles for persistent cell-based regeneration of articular cartilageAndre ... expression of suchproteins during chondrogenesis may serve to delay the onset of hypertrophy and formation of bone, while increasing thepool of proliferating chondrocytes. Indeed, addition of PTHrPhas...
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Báo cáo y học: "Ultrasound has the potential to detect degeneration of articular cartilage clinically, even if the information is obtained from an indirect measurement of intrinsic physical characteristics" pdf
... Nakamura41Division of Motor Function Analysis, Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto,606-8507, Japan2Department of Orthopaedic Surgery, ... intensity (maximum magnitude)correlated significantly with the aggregate modulus of articular cartilage [3]. We mentioned the equations of Youngmodulus, indicating the speed of sound, the density of ... 755-8611, Japan4Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, JapanCorresponding author: Yasuaki Nakagawa, yanakaga@kyotolan.hosp.go.jpPublished:...
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Báo cáo y học: "A proinflammatory role for Fas in joints of mice with collagen-induced arthritis" docx
... Ibrahim11Department of Immunology, University of Rostock, Rostock, Germany2Department of Neurology, University of Rostock, Rostock, Germany3Department of Pathology, University of Rostock, Rostock, Germany4Institute ... anincreased frequency of memory phenotype of lpr T cellsupon stimulation with collagen, phenotypic analysis of sur-face expression of CD44 on T lymphocytes was performed.No change of memory cell populations ... pathology of arthritis in at least two ways: throughpromotion of autoimmunity by blocking tolerance of autore-active lymphocytes and AICD, or through destruction of tar-get tissues by induction of...
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Báo cáo y học: " Multiple shRNA combinations for near-complete coverage of all HIV-1 strains" potx
... cycled at 1×: 94°C for 10 min., 35×: 94°C for 30 sec. | 55°C for 30 sec. | 72°C for 30 sec., and 1 × 72°C for 10 min. End digestions were conducted directly inthe PCR mix (after cycling) by ... co-expression methods, one shouldremain mindful of the possibility of unexpected off-target effects. Additionally, all uses of a lentivirus deliv-ery system for a HIV sequence-specific treatment suchas ... infinitely expand-able MCS [38]. This setup enables any number of PCR/sub-cl oned cassettes to be sequentially inserted by usingrestriction enzymes (REs) that are repeatedly destroyedand simultaneously...
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Báo cáo y học: "Can physical activity improve the mental health of older adults" pps
... Prevention (CDC) calls for increased level of activity by incorporating any activity of at least moderateintensity into the day. For older adults, the daily accumu-lation of PA (stair climbing, ... likely to relapse after 10 months, particularly if theyremain physically active during the follow-up period [32].Finally, the results from the Almada County Studyshowed that physical activity ... [33]. Physical activity and quality of life in older adultsThe large body of research in this area clearly demon-strates that a major aim of PA programs is not just decreas-ing mortality, but...
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Báo cáo y học: "Developments in the scientific and clinical understanding of inflammatory myopathies" pps
... beupregulated by hypoxia, which is also the case for manycytokines that can be found in myositis muscle. Recently, wefound that polymyositis and dermatomyositis patients with ashort duration of symptoms ... characteristic of inclusion body myositis, which isclinically different from polymyositis and dermatomyositis byslowly progressive weakness of proximal leg and distal armmuscles with pronounced atrophy ... muscletissue of both polymyositis and dermatomyositis patients [20].Also, PDCs, the major producers of type I IFN-α, have beenidentified in the muscle tissue of adults with polymyositis,and for distinguishing...
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Báo cáo y học: "Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells" ppsx
... phagocyte stimula-tion. First, the peptides prevent activation of NF-κB by a variety of inflammatory stimuli (reviewed in [4]). Therefore, they mayinhibit MSU crystal-induced secretion of chemoattractantsand ... Gout is an acute form of arthritis caused by thedeposition of urate crystals, in which phagocytic cells andcytokines play a major pathogenic role. We examined whetheralpha-melanocyte-stimulating ... monocytesEffect of the caspase-1 inhibitor z-YVAD-fmk on inflammatory mediator production by monosodium urate (MSU)-stimulated human monocytes. Monocytes were incubated for 18 hours with MSU crystals...
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Báo cáo y học: "Alkylating HIV-1 Nef - a potential way of HIV intervention" ppsx
... center of serine protease ch ymotrypsin andtrypsin, resulting in enzymatic inhibition (EC50 of 20μMand80μM, respectively) [35,36]. TPCK and TLCKalso alkylate the sulfhydryl group of the Cys residue ... (N-a-p-tosyl-L-phenylalanine chloromethylketone) and TLCK (N-a-p-tosyl-L-lysine chloromethylketone) are alkylation reagents that can chemically mod-ify side chains of specific His or Cys residues ... weight of 418 Da, exactlyequal to that of a one TPCK-alkylated Cys. Thus, thecollective MS data proved that TPCK alkylates Cys55and Cys206 but not Cys142 or any His residues.TPCK alkylation...
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Báo cáo y học: "iagnostic Markers based on a Computational Model of Lipoprotein Metabolism" ppsx
... Central. For information about publishing your research in Journal of Clinical Bioinformatics or any BioMedCentral journal, go tohttp://www.jclinbioinformatics.com/authors/instructions/ For information ... treatment in mixed dyslipidemic patients. Fenofibrate and simvastatin clearly raised VLDL performance values. The effect of atorvastatin was borderline significant in the study by Forster et al. ... all the selected studies a group of healthy subjects and a group of patients showing a specific type of dyslipidemia were investigated and compared. Our pool of dyslipidemic subjects was defined...
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Báo cáo y học: "Totally biological composite aortic stentless valved conduit for aortic root replacement: 10-year experience" ppt
... Echocardiography data prior to surgery (mean =120 days; median = 90 days) and early (mean = 43.1days; median= 7 days) and late (mean=4.3 years;median= 4.4 years) after surgeryNvalidMean(SD)Range ... recognition that glutaraldehyde andformaldehyde are prerequisites for limiting calcificationand the importance of preservation of cross-linked col-lagen for the durability of biological tissue [27] ... inflammatory cells of the abscess cavity; Panel D shows the Factor VIII immunoassay of one of the cusps, positive for monolayered endothelial cells.Galiñanes et al. Journal of Cardiothoracic Surgery...
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