Báo cáo y học: "Developments in lupus 2006" pps

... pathway and which B-cell subsets are involved in developing autoimmunity, by using BAFF-Tg mice and other genetically engineered mice. Interestingly, they found that CD40-dependent germinal center ... vascular biology and the immune system. New advances in treating lupus After the demonstration that mycophenolate mofetil is more effective than intravenous cyclophosphamide in inducing...

Ngày tải lên: 09/08/2014, 10:20

... from leukocytes can play a role in inflammatory arthritis by inducing the synthesis of MMPs, chemokines and cytokines in SF [11,12]. It could also be shown that, in particular, the synthesis of ... discovered ‘novel’ cytokines are also involved in promoting joint inflammation in RA. For example, IL-32, which is intensively expressed in RA synovial tissue, resulted in joint infla...

Ngày tải lên: 09/08/2014, 10:20

... transfection or DNA-binding proteins [11,12]. Within the context of SLE, these findings suggest that molecules inducing autoimmunity have intrinsic immunologic activity and may serve as adjuvants ... human leukocyte antigen; IFN = interferon; IRF = interferon regulatory factor; ITGAM = integrin alpha(M); MBL = mannose binding lectin; PDCD = programmed cell death; PTPN = protein tyrosine phosp...

Ngày tải lên: 09/08/2014, 11:20

... complement system, for many years only assessed as a measure of immune complex-mediated activation, is increasingly recognized to play a prominent role in many lupus- associated inflammatory states, including ... Osterland CK, Yeadon C, Smith CD: A long-term study of hydroxychloroquine withdrawal on exacer- bations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study...

Ngày tải lên: 09/08/2014, 14:22

... expansion in lymph nodes and for systemic T cell responses to low antigen concentrations. Int Immunol 2001, 13:1583-1593. 9. Youinou P, Lydyard PM, Mageed RA: B cells underpin lupus immunopathology. Lupus ... mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 1999, 189:1639-1648. 7. Lipsky PE: Systemic lupus ery...

Ngày tải lên: 09/08/2014, 01:21

... to avoid pain that injures a part of the body (for example, removing a finger from a burning stove). All pain in OA is probably not functional. Synovitis-induced inflammatory changes within the joint ... provided new insights into how OA may be successfully managed. The symptoms of osteoarthritis: pain and instability The pain of OA is activity-related, with pain coming on generally only wh...

Ngày tải lên: 09/08/2014, 01:22

... ultimately, of the upregulation of proinflammatory cyto- kines [19,20]. By whichever means they themselves become activated, they induce a plethora of inflammatory products, including degradative enzymes, ... inflammatory events leading to pain, swelling due to synovial thickening and effusion, and stiffness of the joints. While initially individual signs and symptoms, such as swollen joint c...

Ngày tải lên: 09/08/2014, 01:22

... more of the following criteria: fulfilling the clinical symptom of inflammatory back pain, being positive for HLA-B27, or showing evidence of sacroiliitis by imaging [11]. Analyzing 350 referred ... respectively) of clinical symptoms. Andrei Calin, of Bath, UK, had started this kind of work in the early 90s with the definition of the Bath Ankylosing Spondylitis Disease Activity Index (BASDA...

Ngày tải lên: 09/08/2014, 01:22

... exceptionally rare autosomal dominant disease is caused by mutations in the proline serine threonine phosphatase- interacting protein-1 (PTSTPIP) gene encoding a protein also known as CD2-binding protein-1 ... generically as a pyrin domain (PYD) in other proteins that have homology with pyrin’s N-terminal sequence [12]. Members of the death domain superfamily are involved in the assembl...

Ngày tải lên: 09/08/2014, 01:22

... with polymyositis or dermatomyositis, which makes IFN-α a potential specific target for therapy in these patients. Cytokines, chemokines, and prostaglandins Proinflammatory cytokines, chemokines, ... studying the role of immune cells in myositis exists. Thus, a possible way to investigate the molecular pathways in inflammatory myo- pathies is to analyse the molecular expression patterns...

Ngày tải lên: 09/08/2014, 13:21