Báo cáo y học: "Biological therapy in early arthritis – overtreatment or the way to go" pptx

... C-reactive protein levelsChanges in disease activity in 30 patients with rheumatoid arthritis at different times during 78 weeks of infliximab therapy as determined by (a) Disease Activity Score (DAS ... Arnoldi C: Drug-induced lupus following treatment with infliximab in rheumatoid arthritis. Lupus 2002, 11:753-755. 32. Ali Y, Shah S: Infliximab- induced systemic lupus...

Ngày tải lên: 09/08/2014, 01:23

... meet the variable demands imposed by the intermittent course of RA. Evidence from animal models convincingly supports the application of gene therapy in RA, and the feasibility of gene therapy was ... synovial lining layer in both arthritis models. An alternative approach for suicide gene therapy is to inhibit cell proliferation. The cell cycle is contro...

Ngày tải lên: 09/08/2014, 01:24

... of ANA and anti-dsDNA autoantibodies and demonstrated that the induction of ANA, anti-dsDNA and aPL autoantibodies is related to infliximab treatment in both RA and AS, with no significant relationship ... 1- year intervals. ANA, anti-dsDNA and aPL were the only autoantibodies to be significantly induced by infliximab treatment in RA and AS patients. This induction has a...

Ngày tải lên: 09/08/2014, 01:24

... selectins and integrins on synovial endothelium, allowing migration up chemotactic gradients into the joint. The composition of inflammatory cells recruited in a continuing fashion by mast cells, including ... within the inflamed synovium. Equipped with an impressive array of mediators, mast cells can promote synovitis by recruiting inflammatory cells from the blood, inducing syn...

Ngày tải lên: 09/08/2014, 01:24

... important in retaining the cells at this site [17,18]. In about 20% of patients with RA, infiltrating T and B lym- phocytes accumulate underneath the synovial lining layer and organize into lymphocyte ... The induction of BCA-1 and other lymphoid-tissue-inducing chemokines may convert the synovial lesion from an acute to a chronic state by amplifying antigen-specific responses. Blocking...

Ngày tải lên: 09/08/2014, 03:24

... rheumatoid factor; SE = HLA DRB1 shared epitope. Available online http:/ /arthritis- research.com/4/4/R1 Research article B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared ... lymphocytes is plotted on the x axis, and the number of patients in each frequency range is plotted on the y axis. The overlays represent the Ga...

Ngày tải lên: 09/08/2014, 03:24

... RA-induced and RA therapy-induced hyperhomocysteinemia to CHF risk in RA has yet to be completely elucidated. Inflammatory cytokines In patients with overt CHF, levels of inflammatory cytokines (TNF-α, ... progressively failing myocardium) fashion, contributing to subclinical and eventually clinically recognizable ventricular dysfunction (Fig. 1). Inflammatory pathways and myocard...

Ngày tải lên: 09/08/2014, 07:20

... T, et al.: Delay to institution of therapy and induction of remis- sion using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis Rheum ... currently the first line of therapy in early inflammatory disease; however, with the availability of more effective (but more expensive) agents, are we justified in no...

Ngày tải lên: 09/08/2014, 10:20

... prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study Tracey E Toms 1,2 , Vasileios F Panoulas 1 , ... 72.9% females (282/387) and had a median age of 63.1 years. Patients had a median disease duration of 10 years, and had moderate d...

Ngày tải lên: 09/08/2014, 14:22

... found in 3.7% of patients under- going surgery for chronic inflammatory sinusitis [12]. Sinus aspergilloma is often asymptomatic and may therefore be overlooked during the workup performed before ... carried out in the PubMed data- base, using the following keywords: (rheumatoid arthritis OR ankylosing spondylitis OR spondylarthritis) AND (aspergilloma OR fungus ball OR...

Ngày tải lên: 09/08/2014, 14:22

... et al.: Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort. BMC Psychiatry 2011 11:37. Submit your next manuscript to BioMed Central and take ... Access Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort Max Henderson 1* , Ma...

Ngày tải lên: 11/08/2014, 16:23

... 13:R131 http://arthritis-research.com/content/13/4/R131 Page 9 of 10 RESEARCH ARTICLE Open Access Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five ... Assessment Questionnaire; VAS, visual analogous scale; AUC, area under the curve. Table 2 Cardiovascular risk factors and treatment in early...

Ngày tải lên: 12/08/2014, 17:22

... pharmacies dispense lysine vasopressin, or terlipressin (Glypressine đ ; Ferring Company, Berlin, Germany), which is the form of vasopressin that is present in pig. The first clinical trial evaluating the ... report their experience with terlipressin in 16 children with refractory septic shock. Over the past few years there has been much interest in the use of terl...

Ngày tải lên: 12/08/2014, 23:23

... control animals in the Commentary Anticoagulant therapy in acute lung injury: a useful tool without proper operating instruction? Sebastian Rehberg, Perenlei Enkhbaatar and Daniel L Traber Department ... theoretical knowledge adequately into daily clinical practice. Anticoagulant therapy might be a useful tool in the treatment of ALI; however the proper op...

Ngày tải lên: 13/08/2014, 11:22

... properly cited. Research Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study Steffen Weber-Carstens* †1,2 , Maria Deja †1,2 , ... 10.1186/cc9074 Cite this article as: Weber-Carstens et al., Risk factors in critical illness myo- pathy during the early course of critical illn...

Ngày tải lên: 13/08/2014, 20:22