Báo cáo y học: "Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter" docx

... neuropathy confirmed by electromyography, or the diagnosis of Sjögren syndrome based on the clinical symptoms of dry eyes and dry mouth (confirmed by a positive Schirmer's test and/ or kerato- conjunctivitis ... kerato- conjunctivitis sicca with involvement of salivary glands docu- mented by positive lip biopsy and/ or salivary scintigraphy). Simple x-rays of the hands...

Ngày tải lên: 09/08/2014, 10:20

... in the treatment of akathisia, they show only a moderate efficacy, and a substantial proportion of patients fail to respond to treatment. In contrast, under- standing of the pathophysiology of ... with atypical antipsychotic drugs. Although understanding of the pathophysiology of akathisia remains limited, it seems that a complex interplay of several neurotransmitter sys...

Ngày tải lên: 08/08/2014, 23:21

... a purity of 80–90% for the total annexin II as judged by SDS/PAGE. Cleavage of annexin II by MMPs and determina- tion of N-terminal amino acid sequence The proforms of matrilysin and other MMPs ... activates the proforms of these MMPs by producing plasmin [47]. Thus, the cleavage of annexin II by matrilysin may trigger the proteinase amplification cascade or cycling...

Ngày tải lên: 17/03/2014, 17:20

... estimate of the results of a particular study; specifically it shows how the effect size of the study varies from zero. The size of the square shows the weighed individual contribution of the study ... data synthesis, supported general analyses and interpretation of data, and contributed to drafting the manuscript. DS contributed to the design of the stud...

Ngày tải lên: 09/08/2014, 01:21

... regulatory pathways described for IL-18. High affinity binding by IL-18 binding protein a and c isoforms renders these obvious neutralising agents, and early clinical studies to establish the safety of ... components of Commentary Interleukin-18: a therapeutic target in rheumatoid arthritis? Iain B McInnes, Foo Y Liew and J Alastair Gracie Division of Immunology, Infecti...

Ngày tải lên: 09/08/2014, 06:22

... cells, and travel to the synovial membrane where they might appear as type B synoviocytes and promote synovitis [23]. Alternatively, they could travel via the systemic circulation to the subchondral ... link the entity of bone oedema with current theories of the immunopathogenesis of RA. Hirohata and colleagues [23], in a highly accessed article published in Arthritis...

Ngày tải lên: 09/08/2014, 08:23

... fluid IgM reactivity to aggre- can by 21% (p < 0.05) and by 22% (p < 0.01), respectively. On the contrary, neither of the glycosidase cleavages affected reactivity of IgM-type control serum ... highly significant (three-factor ANOVA, F = 30.17 DF = 1.11 p < 0.001), and independent from type of the antigen and from the type of the antibody as well. Arthritis...

Ngày tải lên: 09/08/2014, 13:22

... focused set of analyses that test for heterogeneity in terms of the timing, type, and severity of the trauma. We hypothesize that the effect of PTSD genetic risk variants will be magnified among ... correcting for all tests in a particular gene- by -gene comparison, and also at the experiment-wide level. The standard SNP-by-SNP approach yields powers of 24% an...

Ngày tải lên: 11/08/2014, 17:20

... and is highest in the eye, pin- eal gland, and brain, particularly in the primary sensory cortices (layer IV of the somatosensory cortex) and the suprachiasmatic nuclei of the hypothalamus (reviewed ... al.: Fur- ther evidence for family -genetic risk factors in attention def- icit hyperactivity disorder. Patterns of comorbidity in probands and relatives in psychiat...

Ngày tải lên: 11/08/2014, 17:20

... values. The development of sepsis from a localized infection is a dynamic continuum and in the majority a sequelae of CAP [54]. The severity of a disease determines the con- sumption of costly and ... scores. Discriminatory power of biomarkers for predicting death ranged between 0.60 for PCT to 0.76 for proADM and 0.79 for proANP. CURB65 and PSI score had AUC...

Ngày tải lên: 25/10/2012, 10:02