Báo cáo y học: " High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis" ppsx
Báo cáo y học: " High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis" ppsx
... inhibitor Apolipoprotein A α 1 -Antitrypsin PEDF Fibronectin Tetranectin Fibronectin Clustrin H 4 inhibitor α 1 -Antichymotrypsin Pregnancy zone protein Gelsolin α 1 -Acid glycoprotein Fibrinogen S100 Kinninogen ... individuals, including healthy individuals and patients with early and late OA. Our results show clear differences in protein profiles between healthy and diseased SF...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients" ppsx
... was involved in planning the project, data analysis and writing of the article. A-KU contributed to the planning and design of the project and participated in both the data analysis and writing of ... 12:31-46. 35. Reiner A, Yekutieli D, Benjamini Y: Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 2003, 19:368-375. 36....
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: "High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing" ppsx
... hairpins in a single screening pool, then performed a short-term screen (long enough for viral integration, but minimising hairpin viability effects) and examined the difference in hairpin representation ... the final analysis. Typically, >90% of short reads aligned to the reference shRNA sequence library using this method. Resulting read counts per hairpin were statistically a...
Ngày tải lên: 09/08/2014, 23:20
Báo cáo y học: "Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption" ppt
... inhibited and this led to a reduction in synovial hyperplasia and joint swelling with maintenance of joint integrity [31]. Similar results were obtained in an autoantibody-mediated murine model ... gelatin zymography, and collagenase activity assays using both SW1353 chondrosarcoma cells and primary human chondrocytes. The HDAC inhibitors trichostatin A and sodium butyrate pot...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics" pot
... previous meeting in this series, and further clinical trials seem likely. Introduction Every 3 years, a loosely affiliated network of investigators holds an informal, 2-day meeting to discuss progress in ... International Meeting on Gene Therapy in Rheumatology and Orthopaedics was held in Boston, Massachusetts, USA in May 2004. Keystone lectures delivered by Drs Joseph Glorioso...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro" pps
... in cells of the myeloid lineage such as macrophages and neutrophils [34,35], and is also known to be increased in synovial macro- phages and fibroblasts in RA [36,37] as well as in synovial fluid ... anti-apoptotic proteins, including Mcl-1, Bcl-2, and Bcl-x >L , were determined in rabbit osteoclasts and in cytokine-starved mouse osteoclasts by Western blotting....
Ngày tải lên: 09/08/2014, 14:20
Báo cáo y học: "START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors" potx
... directly by affecting its DNA-binding affinity or inter- action with accessory proteins at the promoter. Alternatively, or in addition, protein-lipid/sterol binding may positively or negatively affect ... proteins differ in plants and animals A subset of animal and plant START proteins contain an amino-terminal PH domain, which is found in a wide variety of eukaryotic proteins impli...
Ngày tải lên: 09/08/2014, 20:20
Báo cáo y học: "CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features" docx
... Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci. J ... immediately clear and can be best assessed experimentally. Discussion CTCF as a model for investigating DNA binding site classes It is becoming increasingly clear that for many DNA binding pro...
Ngày tải lên: 09/08/2014, 20:21
Báo cáo y học: " Chylothorax after surgery on congenital heart disease in newborns and infants – risk factors and efficacy of MCT-diet" pot
... heart surgery, which occurs with an incidence between 0.5% to 6.5%. It may be caused either b y injury of the thoracic d uct, increased pressure in the systemic veins exceeding that in the thoracic ... treatment, and two patients finally died. Conclusions: Chylothorax may appear due to injury of the thoracic duct, due to venous or lymphatic cong estion, central vein thrombosis, or dif...
Ngày tải lên: 10/08/2014, 09:23
Báo cáo y học: "High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis" potx
... positions; and CXC chemokines, with a single amino acid separating the first two cysteines. Cys–X–Cys ligand (CXCL)9 and CXCL10 are members of the small cytokine (intercrine/chemokine) CXC subfamily and ... regions. Twelve samples showed a high number of infiltrating lym- phocytes as well as macrophages, and exhibited a destroyed synovial intima, including fibrin exudation. All RA...
Ngày tải lên: 09/08/2014, 01:23