Báo cáo y học: "Peroxisome proliferator-activated receptor γ

Báo cáo y học: "Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes" doc

... 2 Research article Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes Hassan Afif 1 , ... proliferator-activated receptor γ inhibits interleukin-1β- induced membrane- associated prostaglandin E2 synthase-1 expression in human synov...

Ngày tải lên : 09/08/2014, 10:20

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Báo cáo y học: "κ Exposure to receptor-activator of NFκB ligand renders preγ osteoclasts resistant to IFN-γ by inducing terminal differentiation'''' pdf

... anti-osteoclast activity is mediated by inducing terminal differentiation away from the osteoclast lineage, while IL-4 directly inter- feres with RANKL signaling during osteoclastogenesis. Collectively, these findings ... osteoclastogenesis in vitro, it is also known that this cytokine is produced in particular settings of inflammatory bone loss, such as infection and psoriatic...

Ngày tải lên : 09/08/2014, 01:21

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Báo cáo y học: " Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis" pot

... defense, they also play important roles in inflammatory diseases [4]. Rheumatoid arthritis (RA) is a chronic autoimmune and inflammatory disease characterized by synovial inflammation and destruction ... cell purity was greater than 90% by flow cytometry, and the contaminat- ing cells were mainly non-T non-B cells. Foxp3 staining was performed to compare the purity and its ex...

Ngày tải lên : 09/08/2014, 13:22

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Báo cáo y học: "Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections"

... 14 distress syndrome within 30 days following inclusion. The secondary endpoint was overall survival within 30 days following study inclusion. Outcomes were assessed during hospital stay at days ... cryptate emission. Competing interests No commercial sponsor had any involvement in design and conduct of this study, namely, the collection, management, analysis, and interpretation of the...

Ngày tải lên : 25/10/2012, 10:02

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Báo cáo y học: "Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout Lisa Cammalleri and Mariano Malaguarnera"

... DNA and RNA synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid. Hypoxanthine and guanine may enter in a sal- vage pathway, using hypoxanthine-guanine ... pharmacodynamics It is an enzyme whose action consists in catalyz- ing the oxidation of uric acid into allantoin, rapidly excreted by the kidneys. Allantoin is poor...

Ngày tải lên : 31/10/2012, 14:59

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Báo cáo Y học: The role of hydrophobic active-site residues in substrate speciﬁcity and acyl transfer activity of penicillin acylase pdf

... substrate binding pocket. Few examples exist in which the ratio between hydrolysis and aminolysis was changed by changing the catalytic nucleophile. By replacing the active- site serine in subtilisin ... Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, the Netherlands Penicillin acylase of Escherichia coli catalyses the hydrolysis...

Ngày tải lên : 17/03/2014, 23:20

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Báo cáo khoa học: The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto Functional and structural insights through disulﬁde structure analysis docx

... characterization by mass spectrometry and N-terminal sequencing. These studies showed that Cys115 forms a disulﬁde bond with Cys133, Cys128 with Cys149, and Cys131 with Cys140. Protein database searching and molecular ... 2 is in patterning and morphogenesis in early embryonic development [35,36]. Although JAGGED 2 is not fucosylated as Cripto is [2,12], the function of NO...

Ngày tải lên : 23/03/2014, 21:20

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Báo cáo y học: "Magnetic resonance imaging changes of sacroiliac joints in patients with recent-onset inflammatory back pain: inter-reader reliability and prevalence of abnormalities" potx

... sclerosis, ankylosis), by two observers independently. Agreement between the two readers was analysed by concordance and discordance rates and by kappa statistics. Inflammation was present in 32 ... pain present (%) 96 a HLA-B27 present (%) 46 History of inflammatory bowel disease present (%) 15 History of uveitis present (%) 15 History of psoriasis present (%) 24 Family history o...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx

... (TNF)-α activa-tion, leading to diminished expression of intercellular adhesion mole-cule-1 protein as determined by flow cytometryDnIκB expression in human umbilical vein endothelial cells (HUVECs) ... tumor necrosis factor (TNF)-α stimulation in human umbilical vein endothelial cells (HUVECs) as determined by flow cytometry. Minus and plus signs and denotes resting, n...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations." pps

... KIR3DS1 and the inhibitory 3DL1 are located in the intracytoplasmic tail. The inhibitory receptor has a long tail containing immunoreceptor tyrosine inhibitory motifs, whereas the activating receptor ... of HLA-B27 by KIR or ILT could influence their immunomodulatory function and may imply a role in inflammatory disease. Binding of the KIR3DL1 receptor to the Bw4 family of MHC...

Ngày tải lên : 09/08/2014, 08:22

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