Báo cáo y học: "Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen specie" pptx

... purposes) Vol 9 No 2 Research article Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species Anna-Marie Fairhurst 1 , Paul ... Efficacy of biotinylation was assessed with the 4- hydroxyazobenzene-2-carboxylic acid (HABA) assay. To ensure that the affinity of the antibodies for the...

Ngày tải lên: 09/08/2014, 10:20

... specifically developed for the purposes of this study (e.g., 'Were any of the following a problem for you as a result of using the website? 'Feeling annoyed or upset by the comments made by other ... containing depressive or anxiety psychoeducational information. Objectives of the ANU WellBeing study The primary objectives of the study are to (i) evaluate the efficac...

Ngày tải lên: 11/08/2014, 16:22

... to synoviocytes and osteoclasts. J Clin Invest 1999, 104:137-146. 14. Pap T, Franz JK, Hummel KM, Jeisy E, Gay RE, Gay S: Activation of synovial fibroblasts in rheumatoid arthritis: lack of expres- sion ... coworkers [4] address only part of the several pathways that have been linked to Src and FAK signalling and that are of interest for enhancing our under- standing the compl...

Ngày tải lên: 09/08/2014, 01:22

... filaments are a major component of the cytoskeleton of eukaryotic cells. Together with the actin microfilaments and microtubules, they form an integrated network that is responsible for the mechanical ... disease outcome, especially when high titers of the antibody are present (reviewed in [8]). In an early RA cohort study, the presence of anti-Sa antibodies appeared to be sligh...

Ngày tải lên: 09/08/2014, 01:23

... SF but not PB, potentially by DCs or by T cells or both. In the tissue, as a result of antigen presentation by myeloid DCs or pDCs, key effector cytokines may be produced in perivascular areas ... Kawakami Y, Ikeda Y: Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors. Eur J Immunol 2001, 31:2547-2557. 18. Gilliet M, Liu YJ: Generation o...

Ngày tải lên: 09/08/2014, 06:22

... and/or treated by a physician for hypercho- lesterolemia, hypertension under treatment, smoking history (yes or no), and type I or type II diabetes. We have selected variables in our analysis where ... therapy [40]. Cytokines will also non-specifically activate monocytes and other cells of the innate immune system. RA is characterized by the expansion of autoreactive T-cell clones tha...

Ngày tải lên: 09/08/2014, 06:23

... ‘hyper-ERAD’) by overexpression of Synoviolin triggers synovial cell overgrowth and hence a worsening of RA. Further analysis of the hyper-ERAD system may permit the complex pathomechanisms of RA to ... effects of Synoviolin (Fig. 4e). A search for Synoviolin substrates is also indispensable for the discovery of any as yet unknown crosstalk between signaling pathways involved...

Ngày tải lên: 09/08/2014, 07:20

... properly cited. Abstract The protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene encodes for lymphoid tyrosine phosphatase LYP, involved in the negative regulation of early T-cell activation. An ... variant of LYP could be implicated not only in T-cell activity regulation, but also in B-cell autoreactivity [24]. It will consequently be of major interest to test further...

Ngày tải lên: 09/08/2014, 07:20

... Sedova 3 1 Laboratory of Cancer Cell Biology of the 1 st Faculty of Medicine, Charles University, Prague and the Institute of Physiology, Academy of Sciences, Prague, Czech Republic 2 Department of Medical ... DPPIV activity for peptides involved in metabolism and neuro- physiology would be maintained. Such a trade-off may be accomplished not by complete broad inhibition of DP...

Ngày tải lên: 09/08/2014, 07:20

... end of the follow up period. Cardiovascular disease and risk factors for it CVD was defined as a verified medical history of coronary, cer- ebral or peripheral arterial disease. Coronary artery ... Coronary artery disease included a history of myocardial infarction, a coronary artery by-pass graft procedure, a percutaneous transluminal coro- nary angioplasty or ischemic abnormalitie...

Ngày tải lên: 09/08/2014, 08:22