Báo cáo y học: " Developments in the synovial biology field 2006" potx

... from leukocytes can play a role in inflammatory arthritis by inducing the synthesis of MMPs, chemokines and cytokines in SF [11,12]. It could also be shown that, in particular, the synthesis of ... [40]. Osteoclastogenesis Macrophages/monocytes are not only involved in inflam- matory reactions, but also in the remodeling processes of the bone. Two studies published in the...

Ngày tải lên: 09/08/2014, 10:20

... that pain fibers can be identified in the synovium, in ligaments especially near their insertions, in bone, in muscle, and in the outer third of the meniscus in the knee. In an unusual study in which ... When the joint is young and healthy, complex and overlapping systems protect it from injury. These include the muscles across the joint which contract in a smo...

Ngày tải lên: 09/08/2014, 01:22

... ultimately, of the upregulation of proinflammatory cyto- kines [19,20]. By whichever means they themselves become activated, they induce a plethora of inflammatory products, including degradative enzymes, ... most if not all of the total phenotypic expression of RA, including joint destruction. The fact that CRP is induced by the proinflam- matory cytokine interleukin-6 (IL-6) and th...

Ngày tải lên: 09/08/2014, 01:22

... of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) [21], the Bath Ankylosing Spondylitis Functional Index (BASFI), and the Bath Ankylosing Spondylitis Metrology Index (BASMI) (all ... or more of the following criteria: fulfilling the clinical symptom of inflammatory back pain, being positive for HLA-B27, or showing evidence of sacroiliitis by imaging [11]. Analyzing...

Ngày tải lên: 09/08/2014, 01:22

... generically as a pyrin domain (PYD) in other proteins that have homology with pyrin’s N-terminal sequence [12]. Members of the death domain superfamily are involved in the assembly and activation ... exceptionally rare autosomal dominant disease is caused by mutations in the proline serine threonine phosphatase- interacting protein-1 (PTSTPIP) gene encoding a protein also known as...

Ngày tải lên: 09/08/2014, 01:22

... responses. Furthermore, immune complexes of ANAs can drive the production of proinflammatory cytokines, inducing the ‘interferon signature’, and intensifying disease. Together, these findings point to ... pathways such as transfection or DNA-binding proteins [11,12]. Within the context of SLE, these findings suggest that molecules inducing autoimmunity have intrinsic immunologic activit...

Ngày tải lên: 09/08/2014, 11:20

... studying the role of immune cells in myositis exists. Thus, a possible way to investigate the molecular pathways in inflammatory myo- pathies is to analyse the molecular expression patterns in the target ... with polymyositis or dermatomyositis, which makes IFN-α a potential specific target for therapy in these patients. Cytokines, chemokines, and prostaglandins Proinflammator...

Ngày tải lên: 09/08/2014, 13:21

... the inflammatory effects of MSU [24], suggesting that the pro-inflammatory effects of IL-1 require mesenchymal cells such as the endothelium to respond to this cytokine. Together, these findings ... is the normal product of purine metabolism in humans and in the plasma exists mainly in the form of urate. In the more acidic environment of the renal tubule, however, it i...

Ngày tải lên: 09/08/2014, 13:22

... or inhibitors of inflammatory cytokines. Degeneration of articular cartilage in osteoarthritis: inflammation The role played by inflammatory cytokines and mediators produced by joint tissues in ... proliferation and inflammation It is increasingly appreciated that some degree of synovitis may be observed even in early OA [67]. Synovial histologic changes include synovial hypertrop...

Ngày tải lên: 09/08/2014, 14:20

... serotonin synthesis in enterochromaffin cells in the duodenum. Serotonin appears to inhibit osteo- blast proliferation by binding to its receptor, 5-hydroxy- tryptamine receptor 1B, on the osteoblast ... found that the gene encoding tryptophan hydroxylase (Tph1), a rate- limiting enzyme involved in serotonin synthesis, was highly ciation between the SOST gene and bone mineral de...

Ngày tải lên: 09/08/2014, 14:20