Báo cáo y học: "CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjögren syndrome" docx

... healthy blood donors were genotyped for CTLA-4 CT60 and +49A/G polymorphisms. A second inde- pendent cohort of 139 patients with pSS was further geno- typed for CTLA-4 +49A/G polymorphisms in a ... CTLA-4 CT60 and +49A/G polymor- phisms were genotyped by restriction fragment length poly- morphism with the use of BbvI (+49A/G) and NlaIII (CT60) . Statistical analys...

Ngày tải lên: 09/08/2014, 10:20

Ngày tải lên: 09/08/2014, 10:20

... affected initially, and sepsis leads to severe injury in lung tissue [5]. It has been shown that pericytes in lung tissue produce proinflammatory cytokines in response to lipopolysaccharide ... activities and serum proinflammatory cytokine (TNF-α, IL-1β) le- vels were evaluated by enzyme linked immunosor- bent assay (ELISA) using commercially available kits according to the man...

Ngày tải lên: 25/10/2012, 11:18

... oncology setting. Taking together the promising findings from our study and the literature, need clearly results for inclusion of physical activity programs in comprehensive, complementary treatment ... preliminary evidence for the safety, feasibility, and efficacy of exercise training in breast cancer survivors. The aim of this study was to assess the association between physic...

Ngày tải lên: 08/08/2014, 16:23

... NO in the pathogenesis of joint inflammation. Rodents in animal models of arthritis gener- Figure 3 NOx/creatinine ratios in urine and serumNOx/creatinine ratios in urine and serum. Urine and ... is an inflammatory disease involving joints and other systems including salivary glands. To assess NO production in RA patients, we compared levels of serum, urine, and salivary n...

Ngày tải lên: 09/08/2014, 08:22

... in elucidating the crosstalk between the immune system and bone and in uncovering the mechanism by which sex-steroids, infection and inflammation lead to bone loss by disregulating T lymphocyte ... approximately 50% of the increase in the number of T cells in the periphery, while the remaining 50% is due to enhanced peripheral expansion. Similarly, thymectomy decreases by approx...

Ngày tải lên: 09/08/2014, 10:20

... determined by the amino-terminal end of the ZFs involved, and with the re-engineering of these domains, amino acid composition can be modified to induce highly specific ZFN-target binding [98]. ... DNA helix and cleave it, creating an apurinic/apyrimidinic site (AP site) [29]. The DNA strand is subsequently cleaved by an AP endonuclease and an AP lyase creating a gap which is filled by...

Ngày tải lên: 10/08/2014, 05:21

... resulted in invasion of the thymus by day 14; accompanied by severe thymic atro- phy[17]. In humans, postmortem studies show thymic involu- tion in the severely malnourished[18]. Furthermore, cytokines ... Hebeishy NA, Rahmy AI: A post- mortem study of the thymolymphatic system in protein energy malnutrition. J Trop Med Hyg 1982, 85:109-114. 19. Bodey B, Bodey B Jr, Siegel SE, Kaiser...

Ngày tải lên: 10/08/2014, 05:21

... of subclinical lipoatro- phy. Our findings would also suggest that abdominal adi- posity increases more quickly in HIV-infected men with clinical lipodystophy, compared to those HIV-infected men ... agents and 34 due to diabetes, and 35 due to inconsistent antiretroviral therapy level in the 2 years preceding the first clinical evidence of lipodystrophy. Of the remaining 77 men, match...

Ngày tải lên: 10/08/2014, 05:21

... treatment and disease Longitudinal changes in serum chemistry were exam- ined at different stages of disease and treatment and revealed an initial increase in BUN and creatinine and decrease in phosphorus, ... features of ART nephropathy. Ectasia of renal tubules containing eosinophilic proteinaceous material (tubular proteinosis) (A) and focal lymphocytic infiltrate (B). Mi...

Ngày tải lên: 10/08/2014, 05:21