Báo cáo y học: "Tumor necrosis factor alpha and adalimumab differentially regulate CD36 expression in human monocytes" ppt

... anti-inflammatory properties are used in human ther- apy, regulate in vitro CD36 expression. Aspirin increases CD36 expression in lines of human THP1 macrophages [23], dexamethasone induces CD36 expression ... TNFα and adalimumab, a human anti-TNFα monoclonal antibody widely used in human pathology, in CD36 expression in human monocytes. Human monoc...

Ngày tải lên: 09/08/2014, 10:20

... viability is maintained in the presence of tumor necrosis factor alpha (TNF-α) and/ or epidermal growth factor (EGF)Cell viability is maintained in the presence of tumor necrosis factor alpha (TNF-α) ... involved in regulating the aggrecan and type II collagen genes and in remodeling of the cytoskeleton in response to factors present during inflammation. The MAPK/...

Ngày tải lên: 09/08/2014, 06:22

... that cytokines can be involved in cartilage tissue or proteoglycan degradation [6]. It has recently been shown in a serum-containing porcine in vitro model that these cytokines are able to inhibit ... interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymos...

Ngày tải lên: 09/08/2014, 14:22

... Secondly, TNF-a actsasanautocrinefactorto mediate HBO-induced visfatinproteinexpressionin human CAECs. Thirdly, JNK kinase and AP-1 transcrip- tion factor are involved in the signaling pathways of ... 18:27 http://www.jbiomedsci.com/content/18/1/27 Page 4 of 14 HBO increased AP-1 binding activity. TNF-a antibody and SP600125 inhibited the AP-1 binding activity induced by HBO, indica...

Ngày tải lên: 10/08/2014, 05:21

... Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL: Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest 2003, 111:1221-1230. 5. Boyle WJ, Scott ... assessed by dual energy X-ray absorptiometry [13]. In summary, studies like that by Marotte and colleagues [6] suggest TNF blockade may have a role in prevention of generalised osteoporos...

Ngày tải lên: 09/08/2014, 10:20

... initially treated in a randomized placebo-controlled trial [2] and afterwards Commentary Tumor necrosis factor- αα blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory ... http://arthritis-research.com/content/7/3/R439 123 decrease in the hypervascularity typical of SpA and a reduction of the synovial lining hyperplasia, indicating that infliximab also mo...

Ngày tải lên: 09/08/2014, 06:23

... nuclear factor kappa B subunit p100; RIPK, receptor (tumor necrosis factor receptor superfamily)-interacting serine-threonine kinase 1 and 2; TNFAIP, tumor necrosis factor alpha- induced protein; ... findings indicate TIARP protein expression in the syn- ovium, the results do not link such expression with an amelio- rative or damaging effect on the synovium. Overexpressio...

Ngày tải lên: 09/08/2014, 14:22

... family. They are so called because they have an N-terminal RING finger motif defined by one histidine and seven cysteine residues (C 3 HC 4 ) followed by one or two additional zinc-binding domains ... University of Tokyo, Tokyo, Japan An RBCC (RING finger, B-box, and coiled-coil) protein was identified that belongs to the superfamily of zinc-binding proteins and is specifically expressed in...

Ngày tải lên: 17/03/2014, 10:20

... characterized by a well defined domain structure, consisting of a N-terminal prodomain followed by a metalloproteinase domain, a disintegrin domain, a cysteine rich domain, which usually contains an epithelial ... ADAM (a disintegrin and metalloproteinase) family of type I membrane proteins and mediates the ectodomain shedding of various membrane- anchored signaling and adhesion proteins...

Ngày tải lên: 08/03/2014, 02:20

... the production of the active cytokines interleukin-1b, interleukin-18 and interleukin-33 [6–9]. Involvement of caspase-1 in TNF-a-induced cytotoxicity has been determined by employing inhibitors of caspase-1 [10–12]. ... genes, including interferon regula- tory factor- 1 (IRF-1) [4,5]. Caspase-1 is a cysteine protease that catalyses the proteolytic processing of the pro -in ammatory cyto...

Ngày tải lên: 16/03/2014, 05:20