... expression of β-catenin in joint tissues of patients with RA, but highexpression of the inhibitor of Wnt/β-catenin signaling, DKK-1, in the inflamed synovium, especially in the synoviocytes andsynovial ... that the chondrocytes may not onlyparticipate in the destruction of the cartilage matrix byresponding to the proinflammatory cytokines released from the synovium but may themselves also be the ... interactions involving T and Blymphocytes, monocyte/macrophages, and dendritic cells, several different cytokines are produced in the inflamed synovium as a result of the influx of inflammatory cells...