Báo cáo y học: "Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis" pdf

... purposes) Vol 9 No 1 Research article Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis Susanne G Schäd 1,2 , Andrea Kraus 3 , ... were predominantly of Scandinavian ancestry, and so fair skin is more likely to be present in these children. In addition, they are generally youn...

Ngày tải lên: 09/08/2014, 10:20

... analysis of synovial tissue sections from juvenile idiopathic arthritis (JIA) patientsHistologic analysis of synovial tissue sections from juvenile idiopathic arthritis (JIA) patients. Serial synovial ... PP, Boots AM, Veys EM, Baeten D: Distinct syn- ovial immunopathologic characteristics of juvenile -onset spondylarthritis and other forms of juvenile idiopathic arthritis...

Ngày tải lên: 09/08/2014, 14:22

... radiation (reviewed in [ 37]), p roin¯ammatory c ytokines [30,31] a nd DNA damaging agents [37], whereas the Raf/ERK pathway is preferentially activated upo n binding of growth factors t o receptor tyrosine kinases ... reported by others [28] as a speci®c side-effect of forskolin this compound ab olished ERK1/2 phosphory- lation in the U87 cells used in the present study. Theref...

Ngày tải lên: 17/03/2014, 17:20

... inhibitor of the NF-κB pathway in vivo in a murine arthritis model and in vitro in human synovial cells. Collagen-induced arthritis was induced in mice, and after onset of arthritis the mice were ... suppresses the bone-resorbing activity of mature osteoclasts [39]. Therefore, it is of interest to study further the in vivo effect of this inhibitor on bone-resorbi...

Ngày tải lên: 09/08/2014, 07:20

... almost certainly include pre-existing increased insulin resistance and dysfunction of beta cells. Insulin resistance is present in the acutely ill [13,15,18,28] in different intensity, but the factors ... factors determining the extent of insulin resistance are not known. Our observation that body mass index, which is certainly associated with insulin resistance [29], is highe...

Ngày tải lên: 25/10/2012, 10:02

... during diet therapy than during synthetic folate treatment (p for interaction=0.017), whereas vitamin B12 intake did not change with either form of therapy. 4. DISCUSSION This study shows for ... atherosclerosis, lipid-lowering agents and non-traditional cardiovascular risk factors, with special interest in homocysteine. He is a founding member of the Spanish Atherosclerosis...

Ngày tải lên: 02/11/2012, 11:12

... to the N-terminus of the m ature maltose-binding protein. Binding of the fusion protein to the IMAC gel in buffer containing 50 m M imidazole indicates the presence of the C-terminal histidine ... m M theophylline. The arrow points to the M-A2aTr316-H10 fusion protein. Note that the main contamination, seen in lane 1, run s only m arginally above the hA2aR fusion pro t...

Ngày tải lên: 24/03/2014, 00:21

... average pain intensity and worst pain intensity using a 100 mm VAS after activity in the morning and evening immediately before taking the next dose of study medication. Actual pain intensity difference ... pain intensity = mean of 3-hour and 5-hour assessments. b VAS worst pain intensity = worst pain intensity in the past 12 hours. c VAS average pain intensity = average pain int...

Ngày tải lên: 09/08/2014, 07:20

... patients and healthy control individuals or within the polyarthritis and oligoarthritis groups (P values > 0.05). A is the designation for wild-type; O is the common designation for the variant ... subsequent increased risk for infections, as was previ- ously remonstrated [15,16]. These infections may trigger JRA, as has been hypothesized previously [26]. Another possi...

Ngày tải lên: 09/08/2014, 10:23

... joints involved), polyarticular (five or more joints), and systemic. The systemic onset form, with its markedly febrile presentation, is certainly the most distinct clinical subtype of the disease. ... dysfunction in sJRA. On the basis of our data, the feature that distinguishes sys- temic onset JRA from other forms of JRA, and is common to the major hemophagocytic syn...

Ngày tải lên: 09/08/2014, 06:22