Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis docx

... observations of the therapeutic activity of IL-10 in this model, the nontargeted Figure 3 Cloning, expression and purification of L19 IL-10 and HyHel10–IL-10Cloning, expression and purification of L19 IL-10 ... elements of the L19 IL-10 or HyHEL10 IL-10 fusion proteins. The human IL-10 moiety was fused to the C-terminal of the single-chain Fv antibody fragment...

Ngày tải lên: 09/08/2014, 10:20

... in terms of tumor uptake between the 48 and 96 hour time points. Inhibition of arthritis progression in the collagen- induced model of arthritis The CIA model was used to assess the therapeutic ... preferential accumulation at neovascular sites of cancer and arthritis and capable of inhibiting the progression of established collagen-induced arthritis (CIA...

Ngày tải lên: 09/08/2014, 14:22

... domain of nNOS. CaM is not only essential for the operation of nNOS and the other NOS isoforms, but is also the regulatory protein for a variety of other enzymes, including kinases [27–29]. Two ... Ca 2+ -CaM when it binds to the CaM-binding domain of endothelial nitric oxide synthase (eNOS) [33]. The second example is when the C-terminal lobe of Ca 2+ -CaM binds part o...

Ngày tải lên: 23/03/2014, 09:21

... Cardiovascular disease is the leading cause of death of men and women in the United States and either the primary or secondary cause of death of most men with prostate cancer, and obesity is of widespread ... degree of changes in diet and lifestyle and degree of change in PSA and LNCaP cell growth adds to the strength of evidence. While the evidence linking the eff...

Ngày tải lên: 29/03/2014, 01:20

... patients with BA. The aim of this study was to investigate endotoxin levels in patients with BA and the relation of these levels with the expression of the endotoxin receptor, CD14. Methods: The plasma ... from the circulation within a few minutes of intravenous injection, and the majority of LPS is traced to the liver [6,7]. In addition to clearing LPS, the liver...

Ngày tải lên: 18/06/2014, 16:20

... While some published studies conclude that the use of a standardized extract of the leaves of the Ginkgo biloba tree (EGb 761) reduces the symptoms of mild cognitive disorders including AD [6-8], more ... scrapie [21] and AD [22]. The presence of ginkgolides greatly reduced the activation of apoptotic pathways in these cells. The presence of ginkgolides also reduce...

Ngày tải lên: 19/06/2014, 22:20

... preparation of the figures. SMB was involved with the design and coordination of the study. AL was involved with the design and coordination of the study, drafting and editing of the manuscript. Acknowledgements The ... early target of MEK/ERK signalling and that IL-1 induc- tion of Egr-1 inhibits the activity of the human type II collagen proximal promoter [...

Ngày tải lên: 09/08/2014, 01:22

... future. Gene therapy The current use of gene therapy in the treatment of OA is a result of success in identifying major pathophysiological pathways of the disease process. The principle underlying gene therapy ... with them. Moreover, the use of growth factors in the treatment of OA is a challenging avenue of research, with several problems still to be addressed; amo...

Ngày tải lên: 09/08/2014, 07:20

... out the renal histological analysis. RAL contrib- uted to the development of some of the assays, to the interpre- tation of the data and helping with the manuscript draft. RF helped to design the ... during the most active stage of disease [29]. The discrepancy between the two studies could be due to a number of factors, including the longevity of the injec...

Ngày tải lên: 09/08/2014, 07:20

... gain insight into the mechanisms of these drugs on the OA subchondral bone osteoblasts, we further studied the effect of the therapeutic concentration of these drugs, 20 μg/mL, on the major intracellular ... levels, by limiting the extent of the type I colla- gen degradation as well as the resorptive activity of the subchondral bone. The role of cathepsin K in...

Ngày tải lên: 09/08/2014, 10:23