The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway ppt

... rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti -oxidative pathway Song Ling 1 , Zhanguo Li 1,2 , Olga Borschukova 3 , ... of the SE on the cAMP- and the NO-mediated pathways on the one hand and the proposed role of oxidative stress in the pathogenesis of RA [10-...

Ngày tải lên: 09/08/2014, 10:20

... (trigger the oxidative burst, cytotoxic granule and cytokine release), antigen presen- tation and antibody-dependent cellular cytotoxicity [6]. Con- versely, FcγRIIb contains an inhibitory motif in the ... subtle changes in either expression or structure of these receptors may influence both the susceptibility to RA and the development of nodules. The analyses performed in...

Ngày tải lên: 09/08/2014, 07:20

... of the TGF-b pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther 2007, 9:R59. 58. Maruotti N, Cantatore FP, Crivellato E, Vacca A, Ribatti D: Angio- genesis in rheumatoid arthritis. ... [57,58,85,86]. The affected pathways (and the respective genes) reported here may provide the basis for fur- ther analyses of the RA pathogenesis and the differences...

Ngày tải lên: 09/08/2014, 10:23

... fibrinogen in rheumatoid arthritis. Arthritis Res Ther 2008, 10:R94. 2. Van Venrooij WJ, Van Beers J, Pruijn GJM: Anti-CCP antibody, a marker for the early detection of rheumatoid arthritis. Ann NY Acad ... between susceptibility genes and rheumatoid arthritis. Arthritis Res Ther 2004, 6:1-5. 6. van Gaalen F, Ioan-Facsinay A, Huizinga TW, Toes RE: The devil in the details...

Ngày tải lên: 09/08/2014, 13:21

... section of the manuscript. OP participated in the conceptualization and statistical analysis and in the writing and review of the manuscript. LR wrote sec- tions of the manuscript and reviewed ... of the workforce due to their disability, and yet they still need to do work around the house or someone has to do it for them; therefore, the impact of the condition on unpa...

Ngày tải lên: 09/08/2014, 14:21

... accompanied by the appear- ance and an increase in the 80 kDa fragment (Fig. 2). Although both the untransfected cells and the cells transfected with the vector alone started to show the 80 kDa fragment ... lost. Taken together, our results demonstrate an impor- tant relationship among the regulation of nucleo- lin ⁄ C23, the activation of caspase-3 and the induction...

Ngày tải lên: 16/02/2014, 09:20

... fast. All animal experiments were approved by the University of Cape Town’s Animal Research Ethics Committee, and the investigation conforms to the Guide for the Care and Use of Laboratory Animals ... of 300 lm ADP to the electrode chamber. To test the ability of mitochondria to withstand oxidative stress, 3 mm ADP was added after state 4 respiration, and the chambe...

Ngày tải lên: 18/02/2014, 16:20

... represents the primary defense against O 2 • ) as suggested by its ubiquitous location in the membrane and in the cytoplasm [22], by its constitu- tive level [21] and by the long half-life (2 h) of the mRNA ... the addition of stressors to the cul- tures inhibits growth without killing the cells. The hybridizing band in the northern analysis showed the expected s...

Ngày tải lên: 07/03/2014, 12:20

... siRNA-a, ANT1 siRNA-b, ANT2 siRNA-a and ANT2 siRNA-b were used in the analysis of the cell growth curves. In all the other experiments, ANT1 siRNA and ANT2 siRNA refer to ANT1 siRNA-a and ANT2 siRNA-a, respectively. Transfection ADF ... of ANT2 transcripts in nontransfected, Scramble- and ANT1 and ANT2 siRNA-transfected cells. (D) Western blot analysis of ANT protein in Scramble- and...

Ngày tải lên: 29/03/2014, 09:20

... stimulate the phosphorylation of p47 phox and p67 phox and the GDP/GTP exchange on Rac. The cytosolic components then translocate to the membrane where they form a complex with cytochrome b 558 . The ... into an active GTP-bound form and the phos- phorylation of p47 phox and p67 phox . These subunits then translocate to the membrane where they interact with p22 phox an...

Ngày tải lên: 19/06/2014, 22:20