Review Cells of the synovium in rheumatoid arthritis pot

... The role of T cells in the SKG mutant model has been demonstrated by the predominant infiltration of a Vβ-restricted subset of CD4 + T cells in the inflamed synovium [20]. Adoptive transfer of splenic ... driving synovial inflammation and joint destruction. Information regarding the proinflammatory role of interleukin-17-producing T cells and the functional s...

Ngày tải lên: 09/08/2014, 10:20

... abundant in the synovial lining and sublining layers of the synovium associated with CCL20 (MIP-3α)-expressing cells, as well as in rheumatoid nodules and the synovial fluid. In synovial tissue the ... understanding of RA pathogenesis. In the near future, approaches developed to image DC in situ in patients, and to use DC therapeutically, will help to validate...

Ngày tải lên: 09/08/2014, 10:20

... assess the effects of the inflammatory joint disease on the local remodeling of joint structures. The role of the chondrocyte itself in cartilage destruction in the human rheumatoid joint has ... limited expression of β-catenin in joint tissues of patients with RA, but high expression of the inhibitor of Wnt/β-catenin signaling, DKK-1, in the inflamed...

Ngày tải lên: 09/08/2014, 10:21

... mechanism of degradation of the surface cartilage of the inflamed joint is not fully understood, a combination of the invasive properties of the synovial tissue and the expression of degrading enzymes ... that allow them to resorb bone (Figure 1). One of these is a Review Cells of the synovium in rheumatoid arthritis Osteoclasts Georg Schett Department...

Ngày tải lên: 09/08/2014, 10:20

... chemokines, and form B cell aggregates in the target organ of rheumatoid arthritis. In this review we analyze the multi- faceted role that B cells play in the pathogenesis of rheumatoid arthritis ... and improvement in clinical disease activity, thereby enhancing our understanding of the role played by B cells in human disease. Competing interests The au...

Ngày tải lên: 09/08/2014, 10:20

... altered expression of integrin/selectin pairs on the surface of the two cell types (reviewed in [2]). Because the synovial cytokine milieu (including the Mφ-derived TNF-α) upregulates the expression of these ... dysregulation of the IL-18 system [61]. Interleukin-23 The genuine role of IL-23, a cytokine of the IL-12 family predominantly produced by Mφ or dendriti...

Ngày tải lên: 09/08/2014, 10:22

Ngày tải lên: 09/08/2014, 10:22

... Group Of Clinical Investigators: Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid ... drawback of such PBMC analysis is the lack of a clear-cut relationship between PBMCs and the affected synovium, which prevents the resulting data from providing an un...

Ngày tải lên: 09/08/2014, 08:22

... Prospective trials to determine the role of statins on CV outcome in RA patients will be of great interest. Competing interests The authors declare that they have no competing interests. Authors' ... associations, including statin use, duration of arthritis and the dose of prednisone, the latter of which was not an independent predictor of outcome. CI, confidence...

Ngày tải lên: 09/08/2014, 10:20

... and expression of a variety of genes, including MMP-1, under the influence of TNF-α [3]. The results in the current study have demonstrated that the expression of mRNA for NFκB1 is increased in RA bone ... beneficial effects in the treatment of RA [4]. On the other hand, increas- ing attention has been paid to the role of bone marrow abnor- malities in the...

Ngày tải lên: 09/08/2014, 07:20