Báo cáo khoa học: " The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells" ppt

... for citation purposes) Radiation Oncology Open Access Research The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells James W Welsh* 1 , Daruka Mahadevan 2 , Ron ... survival rates on day 48 (the final day of the experiment) were 0% in both the control and MP470- alone groups, 50% in the radiation- only group (P = 0.035), and 87.5% in...

Ngày tải lên: 09/08/2014, 10:20

... but not in LN229 cells. All of the other six GBM cell lines contain Akt inhibitors increase the radiosensitivity of U87MG cellsFigure 5 Akt inhibitors increase the radiosensitivity of U87MG cells. ... of the PDGF-activated phosphati- dylinositol 3 -kinase. Cell 1995, 81:727-736. 9. Contessa JN, Abell A, Valerie K, Lin PS, Schmidt-Ullrich RK: ErbB receptor tyrosine kinase network...

Ngày tải lên: 09/08/2014, 10:20

... taken and the experiment was started by the addition of agonists to the dishes. Inhibitors were added 10 min before the agonists. The incubation was terminated by rapidly aspirating the medium ... recruited to the IRSs through their src homology 2 domains (a) the growth factor receptor binding protein activates the ras/ mitogen-activated protein kinase pathway and (b) ph...

Ngày tải lên: 20/02/2014, 02:21

... expect the symbol below the top of the stack to give us the node where 3 is adjoined. If r/is not on the spine of an auxiliary tree then it is the only symbol on the stack. We now show how the ... result of the linearity in the rules, the stack ~/a associated with the object in the left-hand side of the derivation and the stack j3cJ associated with one...

Ngày tải lên: 22/02/2014, 10:20

... Chicago, IL, USA). The val- ues shown are the percentage of the intensities of 14-3-3 captured by the peptide compared to the intensity of 14-3-3 applied to the beads (input). These results are ... and had the same effect as the single S242A mutation; therefore, two possibilities are apparent. One is that Ser242 is the major site of the 14-3-3 phospho-dependent interaction...

Ngày tải lên: 23/03/2014, 04:20

... only one copy of the gene for the RPA70kDa subunit in their genome? Furthermore, is only the larg- est subunit of the RPA complex duplicated in plant, and what are the roles of the two RPA types? ... (pairing DNA synthesis) and that the repair synthesis of DNA occurs at pachytene (cross- over DNA synthesis) [172,173]. The two sequential DNA synthesis reactions play a role in...

Ngày tải lên: 23/03/2014, 06:20

... Therefore, it is likely that a proportion of the extra GlcNAc observed is derived from the other APN isoforms present in the protein sample. The glycopeptide data presented in the c urrent ... fragment ions in the MALDI-CID spectra showed that fucose is attached to the C-3 position of the Asn-linked GlcNAc and at the C-3 position of the distal GlcNAc of the chitobiose un...

Ngày tải lên: 23/03/2014, 13:20

... CA). Then the synthetic oligo-nucleotide coding FLAG-tag sequence (5¢-ATATATTGATTACAAGGATGAC GACGATAAGA TA-3¢) was inserted between the AccI site close to the C-terminus of the L protein and the ... confirm the presence of fusion pro- tein at 66.5 kDa. The density of the particles obtained from both cell extracts and the conditioned media was equivalent to that of the BNC....

Ngày tải lên: 23/03/2014, 15:20

... a peg in the discourse model. There are two occasions where the interpreter is unable to map the discourse model to the KB, The first is where the class referenced is unfamiliar to the interpreting ... NP (the object of the preposition) to their right. Further work is needed to describe the ways that various NP types interact as this was a technique for coping with...

Ngày tải lên: 31/03/2014, 06:20

... be checked in the following order: the intensionality of the descrip- tor, the time of reference of the descriptor, and the agents of the descriptor. We must establish the "level" ... whom the target descriptor is ascribed, then the descriptor can be substituted in the target. The resulting clause will have the substituted descriptor attributed...

Ngày tải lên: 31/03/2014, 17:20