Báo cáo khoa học: " The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation" ppsx
... Access Short report The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation John P Alao* and Per Sunnerhagen Address: Department of Cell and Molecular ... observed that in contrast to the ATM selec- tive inhibitor KU55933, ATM/ ATR dual inhibitors such as caffeine and CGK733 can suppress cycl...
Ngày tải lên: 09/08/2014, 10:20
... to remove the protein and ⁄ or the mineral fraction. It is conceivable that the real natural substrates of the CBP proteins differ from the substrates used here and in other stud- ies. There may ... of (GlcNAc) 1–4 was analysed at the start, in the middle and at the end of each series of sam- ples. The resulting average values of the standards (display- ing standard...
Ngày tải lên: 18/02/2014, 08:20
... cells (AR4–2J). Intracellular localization and role in the regulation of the extracellular matrix biosynthesis. Eur.J.CellBiol.69, 316–326. 60. Cao, Y. & Pettersson, R.F. (1993) Release and ... into the mitochondrial matrix (and that the signal peptide cannot be an inhibitor of enzymatic activity as it is not cleaved off in the matrix), it was concluded that the populatio...
Ngày tải lên: 17/03/2014, 03:20
Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf
... platelets, namely the mAb to GPIb, 6D1, and the mAb to a IIb b 3 , LJ-CP8. Taken together, these data are reflective of the ability of saratin to both block VWF–collagen binding and to inhibit a 2 b 1 –collagen ... were observed in the presence of 6D1 (Fig. 7), whereas the number of these small thrombi was significantly reduced in the presence of the a 2 b 1 mAb 6F1 in com-...
Ngày tải lên: 30/03/2014, 09:20
Báo cáo khoa học: "The effect of light acclimation of single leaves on whole tree growth and competition – an application of the tree growth model ALMIS" doc
... either of the other types. Subsequent differences between the carbon gain of the first leaves of the sun type and the adaptive type reflected the interplay between increasing total foliage and ... over 4 hours. Photosynthesis and light interception in the black alder stand are quanti- tatively well-known and well represented in the model, but the parameterization of...
Ngày tải lên: 08/08/2014, 14:22
Báo cáo khoa học: "The use of caspase inhibitors in pulsed-field gel electrophoresis may improve the estimation of radiation-induced DNA repair and apoptosis" pdf
... caspase inhibitors, and improve the estimation of DNA repair, and apoptosis itself. Conclusions: The estimation of radiation-induced DNA repair by PFGE may be improved by the use of apoptosis inhibitors. ... importantly in the conception, design of the study and helped to draft the manuscript. All authors read and approved the final manuscript. Competing interests The...
Ngày tải lên: 09/08/2014, 09:20
Báo cáo khoa học: "The effect of bioequivalent radiation dose on survival of patients with limited-stage small-cell lung cancer" pdf
... study, performed much of the work, and drafted the manuscript. Patient accrual and clinical data collection was done by all authors. XWC and JDZ participated in the analysis and the data interpretation. ... thoracic radiotherapy (TRT) com- bined with chemotherapy represents the standard of car e in the management of limited-stage small -cell lung cancer (LS-SCLC), the o...
Ngày tải lên: 09/08/2014, 09:20
Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
... with the 5¢UTR and 3¢UTR was amplified by PCR and cloned in the pCambia 3300. The HA tag was cloned at the SalI site found at the ATG site of OXI1. Plant material and growth conditions The A. thaliana ... indicated time points. The mixes were then incubated with [c- 32 P]-ATP and MBP (10 l g) for 30 min. The top panel shows the kinase assay visualized by autoradiograp...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt
... signalling and resistance to apoptosis through downregulation of tBid, providing further details on how EGF receptor and proteasome inhibitors can contribute to the induction of apoptosis and the treatment ... USA). Cell transfection and treatments All cells were transfected with the indicated plasmids using calcium ⁄ phosphate [46] and 10 lg plasmid ⁄ 10 cm plate, unless...
Ngày tải lên: 16/02/2014, 09:20