Báo cáo khoa học: " Combined treatment with lexatumumab and irradiation leads to strongly increased long term tumour control under normoxic and hypoxic conditions" potx

... apoptosis inducing antibodies with irradiation strongly increases long- term tumour control. Since murine long- term control experiments are the only cur- rently accepted functional approach to ... irradiation (5× 3 Gy, d1-5) and lexatumumab (0.75 mg/kg, d1, 4 and 8). The tumour bearing hind limbs were irradiated with graded single top up doses at d8 under no...

Ngày tải lên: 09/08/2014, 10:20

... liver, skin and heart [16-18,23-26]. Therefore, together with data on radiation induced PDGF expression and phos- phorylation of PDGFR in vitro and in vivo, and the inhibi- tion by the kinase inhibitors, ... mouse survival following thoracic irradiation and imatinib treatmentFigure 1 (a) Kaplan-Meier analysis of mouse survival following thoracic irradiation and imatinib tre...

Ngày tải lên: 09/08/2014, 10:20

... needs to Fig. 2. TH and DO activities in extracts of wild-type R3 R. solana- cearum and two mutant strains with mutations in the PPO genes RSc0337 and RSc1501. TH activity was determined at pH 5 and 0.05% ... strength was increased with a salt gradient of NaCl up to 1.5 m to elute proteins bound to the anionic gel. Fractions of 1.9 mL were collected, the protein content...

Ngày tải lên: 19/02/2014, 07:20

... considered, and the model for the underlying variable is : 1 Above, s; and 2 s! are the random effects of sire i and maternal grandsire j, 2 f respectively. Under additive ... grandsire model. This can be written as : where Y¡jk is an observation on individual k, with sire i and maternal grandsire j. The scalars s ; and 2 1 s, are the...

Ngày tải lên: 09/08/2014, 22:22

... acyl-enzyme intermediates, and tetrahedral ( 109.5°) water-bonded intermediate. In contrast, serine and thiol protease and amidase are confined to interacting with planar sub- strates and tetrahedral intermediates ... containing a second CX 3 C motif. From top to bottom (with database accession numbers in parentheses): Sulfolobus solfataricus (P95896); Pseudomonas syringae pv....

Ngày tải lên: 07/03/2014, 21:20

... 1986 and 2 in 1987) the number of living beetles on a 1-m long sec- tion of treated wood varied from 0.55 to 2.11 and the number of dead beetles var- ied from 1.82 to ... 2.5-6 g of active ingredient per ha in the control of leaf eating larvae, especially species belonging to the Lepidoptera and Hyme- noptera families. At higher do...

Ngày tải lên: 08/08/2014, 23:21

... rate and extent of saporin entry into the cytosol, which in turn greatly enhanced toxin potency. Dimethylsulfoxide treatment does not induce substantial sensitization to other toxins To determine ... monensin and chloroquine on the endocytosis and toxicity of chimeric toxins. Cell Mol Life Sci 54, 866–875. 11 Cavallaro U & Soria MR (1995) Targeting plant toxins to the urokin...

Ngày tải lên: 07/03/2014, 05:20

... median OS with the combination therapy (docetaxel and S-1) to that in the control arm (S- 1 alone). In total, 638 patients were enrolled (the original Table 3: Hematologic and non-hematologic toxicities Grade ... (4.7%) and anemia (1.2%), which occurred in 55.6% (40/72) within three cycles. However, the hematological and non-hematological tox- icities were both tolerable, except...

Ngày tải lên: 09/08/2014, 03:21

... 2). Toxicity was moderate and summarized in table 4. No hematological grade 3 or 4 toxicities occurred. Hemato- logical toxicity was mild with grade II anemia in 4 patients (9.3%, 95% CI 3–23), and ... rectum needs a long- course of neoadjuvant treatments to reduce tumor volume, to induce down-staging that increases circumferential resection margin, and to facilitate surgery. A...

Ngày tải lên: 09/08/2014, 04:21

... tumor. At laparotomy, the patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, radical right nephrectomy with lymphadenectomy, and left hepatectomy. Pathology ... report Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis Roberto Gedaly* 1 , Hoonbae Jeon 1 , Thomas D Johnston 1 , Patrick P McHugh 1 , Randall G Rowland 2...

Ngày tải lên: 09/08/2014, 07:21